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Research ArticleSpine

Postoperative Lumbar Fusion Bone Morphogenic Protein–Related Epidural Cyst Formation

F. Abel, E.T. Tan, D.B. Sneag, D.R. Lebl and J.L. Chazen
American Journal of Neuroradiology March 2023, 44 (3) 351-355; DOI: https://doi.org/10.3174/ajnr.A7799
F. Abel
aFrom the Departments of Radiology and Imaging (F.A., E.T.T., D.B.S., J.L.C.)
bSpine Surgery (F.A., D.R.L.), Hospital for Special Surgery, New York, New York
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E.T. Tan
aFrom the Departments of Radiology and Imaging (F.A., E.T.T., D.B.S., J.L.C.)
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D.B. Sneag
aFrom the Departments of Radiology and Imaging (F.A., E.T.T., D.B.S., J.L.C.)
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D.R. Lebl
bSpine Surgery (F.A., D.R.L.), Hospital for Special Surgery, New York, New York
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J.L. Chazen
aFrom the Departments of Radiology and Imaging (F.A., E.T.T., D.B.S., J.L.C.)
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    FIG 1.

    Images in a 56-year-old woman approximately 5 months following BMP–augmented extreme lateral and transforaminal lumbar interbody fusion of L3–L5 with persistent left-sided L5 radiculopathy. A, Sagittal T1-weighted MR image of the lumbar spine demonstrates a hypointense epidural collection at L5 (arrow). B, Corresponding sagittal STIR MR image shows the epidural cyst at L5 (black arrow), cystic osteolysis of the L4 and L5 vertebral bodies (white arrows), with endplate edema signal (arrowheads) and postoperative changes. C, Axial T2-weighted image at L5 (blue dashed line, A) illustrates the cyst (dashed black arrow) with the fluid-fluid level that narrows the left subarticular recess. Note the connection of the cyst to the bone resorptions within the vertebral body (arrowheads) and the discontinuity of the posterior longitudinal ligament (white arrow).

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    FIG 2.

    Images in a 49-year-old woman following transforaminal lumbar interbody fusion and left-sided laminotomy of L4–L5 with BMP grafting approximately 8 months ago and new-onset left-sided L4–L5 radiculopathy. A, Sagittal STIR MR image demonstrates a BMP graft with adjacent osteolysis (arrows) and endplate edema signal (arrowheads). B, Axial T2-weighted MR image at L4–L5 (dashed line, A) shows a left-sided epidural cyst (arrows) with a fluid-fluid level. D, Parasagittal T2-weighted MR image at the level of the left laminotomy (dashed blue line, B) illustrates the epidural cyst (arrow) that fills the decompression defect and causes moderate-to-severe foraminal stenosis at L4–L5 (arrowheads). E, Intraoperative photo of the serous cystic structure shows a thick pseudocapsule (asterisks). C and F, Histopathologic specimen (magnification factor, 1.6×/4×, respectively) demonstrates fragments of the thin fibrous cystic lining (arrowheads, F) and a segment of woven bone formation with chondrocytic metaplasia (asterisk, F).

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    FIG 3.

    MR images in a 58-year-old man 2 months following BMP-augmented combined extreme lateral and posterior lumbar interbody fusion with laminectomy of L4–S1 and new-onset left foot drop. A, Sagittal T2-weighted MR image shows a lobulated epidural cyst at L5–S1 dorsal to the BMP graft (black arrows), endplate edema signal of the adjacent endplates (arrowheads), and the laminectomy defect with seroma formation (bracket). B, Axial T2-weighted MR image at L5–S1 (dashed blue line, A) demonstrates the left subarticular, epidural cyst (white arrow) adjacent to the BMP graft, abutting the left descending S1 nerve root (arrowhead) and the left exiting L5 nerve root (black arrow). Concomitant seroma is present and fills the laminectomy defect (asterisks).

Tables

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    Table 1:

    Patients with epidural cysts after use of rhBMP-2

    PatientAge (yr)DiagnosisInterval MR Imaging (days)ProcedureLevels
    149Congenital spinal stenosis253TLIF + laminotomyL4–L5
    256Degenerative spinal stenosis161XLIF + TLIFL3–L5
    352Degenerative spondylolisthesis204ALIFL4–L5
    471Lumbosacral radiculopathy70XLIFL2–L3
    562Lumbosacral radiculopathy119ALIFL5–S1
    657Isthmic spondylolisthesis101PLIF + laminectomyL4–S1
    760Lumbosacral radiculopathy35TLIF + laminectomyL4–L5
    860Pseudoarthrosis480TLIFL4–L5
    964Lumbosacral radiculopathy465XLIFL3–L5
    1051Degenerative spinal stenosis202LLIFL3–L5
    1173Degenerative spinal stenosis61XLIF + laminectomyL3–L4
    1249Degenerative spinal stenosis19PLIF + laminectomyL5–S1
    1361Scoliosis37XLIF + PLIFL4–S1
    1458Degenerative spinal stenosis60XLIF + PLIF + laminectomyL4–S1
    1571Lumbosacral radiculopathy38PLIF + laminectomyL3–L5
    1668Degenerative spinal stenosis134TLIFL4–L5
    • View popup
    Table 2:

    Concurrent imaging findings on the postoperative MRIs

    FindingNo. of Cases%
    Epidural cysts with mass effect8/1650
    Epidural cysts without mass effect8/1650
    Bone resorptions/osteolysis11/1669
    Endplate marrow, edema14/1688
    Seroma11/1669
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American Journal of Neuroradiology: 44 (3)
American Journal of Neuroradiology
Vol. 44, Issue 3
1 Mar 2023
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Cite this article
F. Abel, E.T. Tan, D.B. Sneag, D.R. Lebl, J.L. Chazen
Postoperative Lumbar Fusion Bone Morphogenic Protein–Related Epidural Cyst Formation
American Journal of Neuroradiology Mar 2023, 44 (3) 351-355; DOI: 10.3174/ajnr.A7799

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Postop Lumbar Fusion BMP-Related Epidural Cyst
F. Abel, E.T. Tan, D.B. Sneag, D.R. Lebl, J.L. Chazen
American Journal of Neuroradiology Mar 2023, 44 (3) 351-355; DOI: 10.3174/ajnr.A7799
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