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Research ArticleNeuroimaging Physics/Functional Neuroimaging/CT and MRI Technology

Asymmetry of the Frontal Aslant Tract Depends on Handedness

Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar and Haris I. Sair
American Journal of Neuroradiology August 2024, 45 (8) 1090-1097; DOI: https://doi.org/10.3174/ajnr.A8270
Mohammad Taghvaei
aFrom the Department of Neurology (M.T.), University of Pennsylvania, Philadelphia, Pennsylvania
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Craig K. Jones
bDepartment of Computer Science (C.K.J.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
cThe Malone Center for Engineering in Healthcare (C.K.J., H.I.S.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Licia P. Luna
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Sachin K. Gujar
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Haris I. Sair
cThe Malone Center for Engineering in Healthcare (C.K.J., H.I.S.), The Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland
dThe Russell. H. Morgan Department of Radiology and Radiological Science (C.K.J., L.P.L., S.K.G., H.I.S.), Johns Hopkins University School of Medicine, Baltimore, Maryland
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Abstract

BACKGROUND AND PURPOSE: The human brain displays structural and functional disparities between its hemispheres, with such asymmetry extending to the frontal aslant tract. This plays a role in a variety of cognitive functions, including speech production, language processing, and executive functions. However, the factors influencing the laterality of the frontal aslant tract remain incompletely understood. Handedness is hypothesized to impact frontal aslant tract laterality, given its involvement in both language and motor control. In this study, we aimed to investigate the relationship between handedness and frontal aslant tract lateralization, providing insight into this aspect of brain organization.

MATERIALS AND METHODS: The Automated Tractography Pipeline was used to generate the frontal aslant tract for both right and left hemispheres in a cohort of 720 subjects sourced from the publicly available Human Connectome Project in Aging database. Subsequently, macrostructural and microstructural parameters of the right and left frontal aslant tract were extracted for each individual in the study population. The Edinburgh Handedness Inventory scores were used for the classification of handedness, and a comparative analysis across various handedness groups was performed.

RESULTS: An age-related decline in both macrostructural parameters and microstructural integrity was noted within the studied population. The frontal aslant tract demonstrated a greater volume and larger diameter in male subjects compared with female participants. Additionally, a left-side laterality of the frontal aslant tract was observed within the general population. In the right-handed group, the volume (P < .001), length (P < .001), and diameter (P = .004) of the left frontal aslant tract were found to be higher than those of the right frontal aslant tract. Conversely, in the left-handed group, the volume (P = .040) and diameter (P = .032) of the left frontal aslant tract were lower than those of the right frontal aslant tract. Furthermore, in the right-handed group, the volume and diameter of the frontal aslant tract showed left-sided lateralization, while in the left-handed group, a right-sided lateralization was evident.

CONCLUSIONS: The laterality of the frontal aslant tract appears to differ with handedness. This finding highlights the complex interaction between brain lateralization and handedness, emphasizing the importance of considering handedness as a factor in evaluating brain structure and function.

ABBREVIATIONS:

AD
axial diffusivity
EHI
Edinburgh Handedness Inventory
FA
fractional anisotropy
FAT
frontal aslant tract
FDR
false discovery rate
HCP
Human Connectome Project
HCP-A
HCP Lifespan in Aging
ICV
intracranial volume
LH
left-handed
LI
lateralization index
MD
mean diffusivity
RD
radial diffusivity
RH
right-handed
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American Journal of Neuroradiology: 45 (8)
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Cite this article
Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar, Haris I. Sair
Asymmetry of the Frontal Aslant Tract Depends on Handedness
American Journal of Neuroradiology Aug 2024, 45 (8) 1090-1097; DOI: 10.3174/ajnr.A8270

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Frontal Aslant Tract Asymmetry and Handedness
Mohammad Taghvaei, Craig K. Jones, Licia P. Luna, Sachin K. Gujar, Haris I. Sair
American Journal of Neuroradiology Aug 2024, 45 (8) 1090-1097; DOI: 10.3174/ajnr.A8270
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