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Review ArticleReview Article

Imaging Findings in Giant Cell Arteritis: Don’t Turn a Blind Eye to the Obvious!

Girish Bathla, Amit K. Agarwal, Steven A. Messina, David F. Black, Neetu Soni, Felix E. Diehn, Norbert G. Campeau, Vance T. Lehman, Kenneth J. Warrington, Rennie L. Rhee and Thorsten A. Bley
American Journal of Neuroradiology March 2025, 46 (3) 457-464; DOI: https://doi.org/10.3174/ajnr.A8388
Girish Bathla
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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Amit K. Agarwal
bDepartment of Radiology (A.K.A., N.S.), Mayo Clinic, Jacksonville, Florida
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Steven A. Messina
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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David F. Black
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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Neetu Soni
bDepartment of Radiology (A.K.A., N.S.), Mayo Clinic, Jacksonville, Florida
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Felix E. Diehn
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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Norbert G. Campeau
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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Vance T. Lehman
aFrom the Department of Radiology (G.B., S.A.M., D.F.B., F.E.D., N.G.C., V.T.L.), Mayo Clinic, Rochester, Minnesota
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Kenneth J. Warrington
cDepartment of Internal Medicine (Rheumatology) (K.J.W.), Mayo Clinic, Rochester, Minnesota
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Rennie L. Rhee
dDepartment of Medicine/Rheumatology (R.L.R.), Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
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Thorsten A. Bley
eDepartment of Diagnostic and Interventional Radiology (T.A.B.), University Medical Center Würzburg, Würzburg, Germany
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Graphical Abstract

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SUMMARY:

Giant cell arteritis (GCA) is the most common primary large vessel systemic vasculitis in the Western World. Even though the involvement of scalp and intracranial vessels has received much attention in the neuroradiology literature, GCA, being a systemic vasculitis, can involve multiple other larger vessels including the aorta and its major head and neck branches. Herein, the authors present a pictorial review of the various cranial, extracranial, and orbital manifestations of GCA. An increased awareness of this entity may help with timely and accurate diagnosis, helping expedite therapy and preventing serious complications.

ABBREVIATIONS:

ACR
American College of Rheumatology
AION
anterior ischemic optic neuropathy
ESR
erythrocyte sedimentation rate
EULAR
European League Against Rheumatism
GCA
giant cell arteritis
LV-GCA
large vessel GCA
PMR
polymyalgia rheumatica
TAB
temporal artery biopsy
VWI
vessel wall imaging
STA
superficial temporal artery
  • © 2025 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 46 (3)
American Journal of Neuroradiology
Vol. 46, Issue 3
1 Mar 2025
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Cite this article
Girish Bathla, Amit K. Agarwal, Steven A. Messina, David F. Black, Neetu Soni, Felix E. Diehn, Norbert G. Campeau, Vance T. Lehman, Kenneth J. Warrington, Rennie L. Rhee, Thorsten A. Bley
Imaging Findings in Giant Cell Arteritis: Don’t Turn a Blind Eye to the Obvious!
American Journal of Neuroradiology Mar 2025, 46 (3) 457-464; DOI: 10.3174/ajnr.A8388

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Giant Cell Arteritis: Important Imaging Findings
Girish Bathla, Amit K. Agarwal, Steven A. Messina, David F. Black, Neetu Soni, Felix E. Diehn, Norbert G. Campeau, Vance T. Lehman, Kenneth J. Warrington, Rennie L. Rhee, Thorsten A. Bley
American Journal of Neuroradiology Mar 2025, 46 (3) 457-464; DOI: 10.3174/ajnr.A8388
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    • VASCULAR FINDINGS IN CRANIAL GCA
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