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Research ArticlePediatric Neuroimaging

CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis

A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff and European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
American Journal of Neuroradiology March 2025, 46 (3) 536-543; DOI: https://doi.org/10.3174/ajnr.A8496
A. Tietze
aFrom the Institute of Neuroradiology (A.T.), Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Germany
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B. Bison
bDepartment of Neuroradiology (B.B.), University Hospital Augsburg, Augsburg, Germany
cFaculty of Medicine (B.B.), Neuroradiological Reference Center for the pediatric brain tumor studies of the German Society of Pediatric Oncology and Hematology, University Augsburg, Augsburg, Germany
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J. Engelhardt
dService de Neurochirurgie B (J.E.), Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
eUniversity Bordeaux (J.E.), Bordeaux INP, CNRS, IMB, UMR 5251, Talence, France
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T. Fenouil
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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D. Figarella-Branger
gInstitute Neurophysiopathol (D.F.-B.), Aix-Marseille University, APHM, CNRS, INP, centre hospitalier universitaire Timone, Service d’Anatomie Pathologique et de Neuropathologie, Marseille, France
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E. Goebell
hDepartment of Diagnostic and Interventional Neuroradiology (E.G.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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J. Hakumäki
iDepartment of Clinical Radiology (J.H.), Kuopio University Hospital, Kuopio, Finland
jInstitute of Clinical Medicine (J.H.), University of Eastern Finland, Kuopio, Finland
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E. Koscielniak
kDepartment of Pediatric Oncology/Hematology/Immunology (E.K.), Olgahospital, Klinikum Stuttgart, Stuttgart, Germany
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L.E. Ludlow
lMurdoch Children’s Research Institute (L.E.L.), and Children’s Cancer Centre (L.E.L.), The Royal Children’s Hospital, Parkville, Victoria, Australia
mDepartment of Paediatrics (L.E.L.), The University of Melbourne, Parkville, Victoria, Australia
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D. Meyronet
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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P. Nyman
nCrown Princess Victoria Children´s Hospital (P.N.), Linköping University Hospital, Linköping, Sweden
oDepartment of Biomedical and Clinical Sciences (P.N.), Linköping University, Linköping, Sweden
pClinical Sciences, Pediatric Oncology and Hematology (I.O.), Lund University, Lund, Sweden
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I. Øra
qDepartment of Pediatrics (J.P.), Pediatric Hematology and Oncology Ward, Kuopio University Hospital, Kuopio, Finland
rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
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J. Pesola
rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
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T. Rauramaa
rInstitute of Clinical Medicine (J.P., T.R.) University of Eastern Finland, Kuopio, Finland
sDepartment of Clinical Pathology (T.R.), Kuopio University Hospital, Kuopio, Finland
tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
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R.E. Reddingius
tDepartment of Clinical Pathology (T.R.), Kuopio University Hospital and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
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D. Samuel
vDepartment of Pediatric Hematology-Oncology (D.S.), Valley Children’s Hospital, Madera, California
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A. Sexton-Oates
wRare Cancers Genomics Team (A.S.-O.), Genomic Epidemiology Branch, International Agency for Research on Cancer/World Health Organization, Lyon, France
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A. Vasiljevic
fInstitut de Pathologie Multisite-Site Est (T.F., D.M., A.V.), Groupement Hospitalier Est, Hospices Civils de Lyon, Lyon, France
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A.K. Wefers
xInstitute of Neuropathology (A.K.W.), and Mildred Scheel Cancer Career Center HaTriCS4 (A.K.W.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany
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J. Zamecnik
yDepartment of Pathology and Molecular Medicine (J.Z.), Second Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic
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D.T.W. Jones
zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany
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M.K. Keck
zDivision of Pediatric Glioma Research (D.T.W.J., M.K.K.), Hopp Children’s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany
aaNational Center for Tumor Diseases (NCT) (D.T.W.J., M.K.K.), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany
bbGerman Cancer Research Center (DKFZ) (D.T.W.J., M.K.K.), Heidelberg, Germany
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K. von Hoff
ccDepartment of Pediatric Oncology and Hematology (K.v.H.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany
ddDepartment of Paediatric and Adolescent Medicine (K.v.H.), Aarhus University Hospital, Aarhus, Denmark
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eeCollaborators from the European Society for Paediatric Oncology (SIOPE)
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American Journal of Neuroradiology: 46 (3)
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A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis
American Journal of Neuroradiology Mar 2025, 46 (3) 536-543; DOI: 10.3174/ajnr.A8496

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New CNS Embryonal Tumor Insights via MRI Analysis
A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
American Journal of Neuroradiology Mar 2025, 46 (3) 536-543; DOI: 10.3174/ajnr.A8496
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  • Comparative Clinical and Imaging‐Based Evaluation of Therapeutic Modalities in CNS Embryonal Tumours With PLAGL Amplification
    Michaela‐Kristina Keck, Anna Tietze, Brigitte Bison, Shivaram Avula, Julien Engelhardt, Cécile Faure‐Conter, Tanguy Fenouil, Dominique Figarella‐Branger, Einar Goebell, Johannes Gojo, Christine Haberler, Juhana Hakumäki, James T. Hayden, Laura S. Korhonen, Ewa Koscielniak, Christof M. Kramm, Mariëtte E. G. Kranendonk, Maarten Lequin, Louise E. Ludlow, David Meyronet, Per Nyman, Ingrid Øra, Thomas Perwein, Jouni Pesola, Tuomas Rauramaa, Roel Reddingius, David Samuel, Antoinette Y. N. Schouten‐van Meeteren, Alexandra Sexton‐Oates, Alexandre Vasiljevic, Thekla von Kalle, Annika K. Wefers, Pieter Wesseling, Josef Zamecnik, Michal Zapotocky, Katja von Hoff, David T. W. Jones
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