More articles from ADULT BRAIN
- Monoclonal Antibodies: What the Diagnostic Neuroradiologist Needs to Know
The therapeutic use of monoclonal antibodies is rapidly expanding for a variety of diseases. This review article describes commonly used monoclonal antibody-targeted therapeutic agents, their mechanism of action, clinical applications, and major adverse events with a focus on neurologic and neuroimaging manifestations. For example, immunostimulating anticancer mAbs can lead to proinflammatory conditions, while immunosuppressive medications can lead to activation of underlying opportunistic infections. Amyloid-segregating mAbs can lead to amyloid-related imaging abnormalities, and TNF-inhibiting mAbs have a higher incidence of demyelinating abnormalities.
- Prospective, Longitudinal Study of Clinical Outcome and Morphometric Posterior Fossa Changes after Craniocervical Decompression for Symptomatic Chiari I Malformation
This prospective, longitudinal study of patients with Chiari I malformation posterior fossa dural opening and duraplasty quantified the change in the posterior fossa and upper cervical spine morphometrics and determined the change in symptomatology between at baseline and up to 5 years postsurgery. The authors found that symptomatic and MR imaging morphometric changes occurred within the first postoperative year.
- Long-Term Follow-up of Multinodular and Vacuolating Neuronal Tumors and Implications for Surveillance Imaging
Multinodular and vacuolating neuronal tumors (MVNTs) are classified as WHO grade 1 tumors and typically described as “leave me alone” lesions. Less frequent surveillance imaging can be performed based on the longitudinal volumetric stability of these lesions.