Dissociation of Structural and Functional Connectivity and Metabolism in the Neocortex of Idiopathic Generalized Epilepsy: A Simultaneous PET/MRI Multimodal Study

References

1. 1.↵
   1. Devinsky O,
   2. Elder C,
   3. Sivathamboo S, et al

   . Idiopathic generalized epilepsy: misunderstandings, challenges, and opportunities. Neurology 2024;102:e208076 doi:10.1212/WNL.0000000000208076 pmid:38165295

   CrossRefPubMed
2. 2.↵
   1. Verducci C,
   2. Hussain F,
   3. Donner E, et al

   . SUDEP in the North American SUDEP Registry: the full spectrum of epilepsies. Neurology 2019;93:e227–36 doi:10.1212/WNL.0000000000007778 pmid:31217259

   CrossRefPubMed
3. 3.↵
   1. Piper RJ,
   2. Richardson RM,
   3. Worrell G, et al

   . Towards network-guided neuromodulation for epilepsy. Brain 2022;145:3347–62 doi:10.1093/brain/awac234 pmid:35771657

   CrossRefPubMed
4. 4.↵
   1. Moeller F,
   2. Maneshi M,
   3. Pittau F, et al

   . Functional connectivity in patients with idiopathic generalized epilepsy. Epilepsia 2011;52:515–22 doi:10.1111/j.1528-1167.2010.02938.x pmid:21269293

   CrossRefPubMedWeb of Science
5. 5.↵
   1. Acharya UR,
   2. Oh SL,
   3. Hagiwara Y, et al

   . Deep convolutional neural network for the automated detection and diagnosis of seizure using EEG signals. Comput Biol Med 2018;100:270–78 doi:10.1016/j.compbiomed.2017.09.017 pmid:28974302

   CrossRefPubMed
6. 6.↵
   1. Rho JM,
   2. Boison D

   . The metabolic basis of epilepsy. Nat Rev Neurol 2022;18:333–47 doi:10.1038/s41582-022-00651-8 pmid:35361967

   CrossRefPubMed
7. 7.↵
   1. Liao C,
   2. Wang K,
   3. Cao X, et al

   . Detection of lesions in mesial temporal lobe epilepsy by using MR fingerprinting. Radiology 2018;288:804–12 doi:10.1148/radiol.2018172131 pmid:29916782

   CrossRefPubMed
8. 8.↵
   1. Larivière S,
   2. Rodríguez-Cruces R,
   3. Royer J, et al

   . Network-based atrophy modeling in the common epilepsies: a worldwide ENIGMA study. Sci Adv 2020;6:eabc6457 doi:10.1126/sciadv.abc6457

   FREE Full Text
9. 9.↵
   1. Wandschneider B,
   2. Hong SJ,
   3. Bernhardt BC, et al

   . Developmental MRI markers cosegregate juvenile patients with myoclonic epilepsy and their healthy siblings. Neurology 2019;93:e1272–e1280 doi:10.1212/WNL.0000000000008173 pmid:31467252

   Abstract/FREE Full Text
10. 10.↵
    1. McGill ML,
    2. Devinsky O,
    3. Kelly C, et al

    . Default mode network abnormalities in idiopathic generalized epilepsy. Epilepsy Behav 2012;23:353–59 doi:10.1016/j.yebeh.2012.01.013 pmid:22381387

    CrossRefPubMed
11. 11.↵
    1. Hu J,
    2. Ran H,
    3. Chen G, et al

    . Altered neurovascular coupling in children with idiopathic generalized epilepsy. CNS Neurosci Ther 2023;29:609–18 doi:10.1111/cns.14039 pmid:36480481

    CrossRefPubMed
12. 12.↵
    1. Wang J,
    2. Guo K,
    3. Cui B, et al

    . Individual [18F]FDG PET and functional MRI based on simultaneous PET/MRI may predict seizure recurrence after temporal lobe epilepsy surgery. Eur Radiol 2022;32:3880–88 doi:10.1007/s00330-021-08490-9 pmid:35024947

    CrossRefPubMed
13. 13.↵
    1. Gong Q,
    2. Lui S,
    3. Sweeney JA

    . A selective review of cerebral abnormalities in patients with first-episode schizophrenia before and after treatment. Am J Psychiatry 2016;173:232–43 doi:10.1176/appi.ajp.2015.15050641 pmid:26621570

    CrossRefPubMed
14. 14.↵
    1. Engel J Jr.

    ; International League Against Epilepsy (ILAE). A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE Task Force on Classification and Terminology. Epilepsia 2001;42:796–803 doi:10.1046/j.1528-1157.2001.10401.x pmid:11422340

    CrossRefPubMedWeb of Science
15. 15.↵
    1. Hirsch E,
    2. French J,
    3. Scheffer IE, et al

    . ILAE definition of the idiopathic generalized epilepsy syndromes: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia 2022;63:1475–99 doi:10.1111/epi.17236 pmid:35503716

    CrossRefPubMed
16. 16.↵
    1. Shehzad Z,
    2. Kelly C,
    3. Reiss PT, et al

    . A multivariate distance-based analytic framework for connectome-wide association studies. NeuroImage 2014;93(Pt 1):74–94 doi:10.1016/j.neuroimage.2014.02.024 pmid:24583255

    CrossRefPubMed
17. 17.↵
    1. Dwyer DB,
    2. Falkai P,
    3. Koutsouleris N

    . Machine learning approaches for clinical psychology and psychiatry. Annu Rev Clin Psychol 2018;14:91–118 doi:10.1146/annurev-clinpsy-032816-045037 pmid:29401044

    CrossRefPubMed
18. 18.↵
    1. Yeo BTT,
    2. Krienen FM,
    3. Sepulcre J, et al

    . The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol 2011;106:1125–65 doi:10.1152/jn.00338.2011 pmid:21653723

    CrossRefPubMedWeb of Science
19. 19.↵
    1. Collins GS,
    2. Reitsma JB,
    3. Altman DG, et al

    . Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD): the TRIPOD statement. BMJ 2015;350:g7594 doi:10.1136/bmj.g7594 pmid:25569120

    CrossRefPubMed
20. 20.↵
    1. Perucca E,
    2. Perucca P,
    3. White HS, et al

    . Drug resistance in epilepsy. Lancet Neurol 2023;22:723–34 doi:10.1016/S1474-4422(23)00151-5 pmid:37352888

    CrossRefPubMed
21. 21.↵
    1. Wu D,
    2. Schaper F,
    3. Jin G, et al

    . Human anterior thalamic stimulation evoked cortical potentials align with intrinsic functional connectivity. Neuroimage 2023;277:120243 doi:10.1016/j.neuroimage.2023.120243 pmid:37353098

    CrossRefPubMed
22. 22.↵
    1. Hatton SN,
    2. Huynh KH,
    3. Bonilha L, et al

    . White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA-Epilepsy study. Brain 2020;143:2454–73 doi:10.1093/brain/awaa200 pmid:32814957

    CrossRefPubMed
23. 23.↵
    1. Hogan RE

    . Epilepsy as a disease of white matter. Epilepsy Curr 2021;21:27–29 doi:10.1177/1535759720975744 pmid:34025269

    CrossRefPubMed
24. 24.↵
    1. Scott RC

    . What are the effects of prolonged seizures in the brain? Epileptic Disord 2014;16(Spec No 1):S6–11 doi:10.1684/epd.2014.0689 pmid:25323416

    CrossRefPubMed
25. 25.↵
    1. Thompson K

    . Status epilepticus and early development: neuronal injury, neurodegeneration, and their consequences. Epilepsia Open 2023;8(Suppl 1):S110–16 doi:10.1002/epi4.12601 pmid:35434910

    CrossRefPubMed
26. 26.↵
    1. Jiang S,
    2. Pei H,
    3. Huang Y, et al

    . Dynamic temporospatial patterns of functional connectivity and alterations in idiopathic generalized epilepsy. Int J Neural Syst 2020;30:2050065 doi:10.1142/S0129065720500653 pmid:33161788

    CrossRefPubMed
27. 27.↵
    1. Anderson J,
    2. Hamandi K

    . Understanding juvenile myoclonic epilepsy: contributions from neuroimaging. Epilepsy Res 2011;94:127–37 doi:10.1016/j.eplepsyres.2011.03.008 pmid:21482074

    CrossRefPubMed
28. 28.↵
    1. Bartolini E,
    2. Pesaresi I,
    3. Fabbri S, et al

    . Abnormal response to photic stimulation in juvenile myoclonic epilepsy: an EEG-fMRI study. Epilepsia 2014;55:1038–47 doi:10.1111/epi.12634 pmid:24861441

    CrossRefPubMed
29. 29.↵
    1. Gotman J,
    2. Grova C,
    3. Bagshaw A, et al

    . Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. Proc Natl Acad Sci U S A 2005;102:15236–40 doi:10.1073/pnas.0504935102 pmid:16217042

    Abstract/FREE Full Text
30. 30.↵
    1. Catani M,
    2. Dell’acqua F,
    3. Thiebaut de Schotten M

    . A revised limbic system model for memory, emotion and behaviour. Neurosci Biobehav Rev 2013;37:1724–37 doi:10.1016/j.neubiorev.2013.07.001 pmid:23850593

    CrossRefPubMed
31. 31.↵
    1. Alves PN,
    2. Foulon C,
    3. Karolis V, et al

    . An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings. Commun Biol 2019;2:370 doi:10.1038/s42003-019-0611-3 pmid:31633061

    CrossRefPubMed
32. 32.↵
    1. Guo K,
    2. Wang J,
    3. Cui B, et al

    . [¹⁸F]FDG PET/MRI and magnetoencephalography may improve presurgical localization of temporal lobe epilepsy. Eur Radiology 2022;32:3024–34 doi:10.1007/s00330-021-08336-4 pmid:34651211

    CrossRefPubMed
33. 33.↵
    1. Tangwiriyasakul C,
    2. Perani S,
    3. Centeno M, et al

    . Dynamic brain network states in human generalized spike-wave discharges. Brain 2018;141:2981–94 doi:10.1093/brain/awy223 pmid:30169608

    CrossRefPubMed
34. 34.↵
    1. Ravizza T,
    2. Scheper M,
    3. Di Sapia R, et al

    . mTOR and neuroinflammation in epilepsy: implications for disease progression and treatment. Nat Rev Neurosci 2024;25:334–50 doi:10.1038/s41583-024-00805-1 pmid:38531962

    CrossRefPubMed
35. 35.↵
    1. Vezzani A,
    2. Balosso S,
    3. Ravizza T

    . Neuroinflammatory pathways as treatment targets and biomarkers in epilepsy. Nat Rev Neurol 2019;15:459–72 doi:10.1038/s41582-019-0217-x pmid:31263255

    CrossRefPubMed
36. 36.↵
    1. Khambhati AN,
    2. Shafi A,
    3. Rao VR, et al

    . Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy. Sci Transl Med 2021;13:eabf6588 doi:10.1126/scitranslmed.abf6588

    Abstract/FREE Full Text
37. 37.↵
    1. Akyuz E,
    2. Polat AK,
    3. Eroglu E, et al

    . Revisiting the role of neurotransmitters in epilepsy: an updated review. Life Sci 2021;265:118826 doi:10.1016/j.lfs.2020.118826 pmid:33259863

    CrossRefPubMed
38. 38.↵
    1. Pan G,
    2. Chen Z,
    3. Zheng H, et al

    . Compensatory mechanisms modulate the neuronal excitability in a kainic acid-induced epilepsy mouse model. Front Neural Circuits 2018;12:48 doi:10.3389/fncir.2018.00048 pmid:30008664

    CrossRefPubMed
39. 39.↵
    1. Qi Y,
    2. Zhang YM,
    3. Gao YN, et al

    . AMPK role in epilepsy: a promising therapeutic target? J Neurol 2024;271:748–71 doi:10.1007/s00415-023-12062-w pmid:38010498

    CrossRefPubMed
40. 40.↵
    1. O’Muircheartaigh J,
    2. Vollmar C,
    3. Barker GJ, et al

    . Abnormal thalamocortical structural and functional connectivity in juvenile myoclonic epilepsy. Brain 2012;135:3635–44 doi:10.1093/brain/aws296 pmid:23250883

    CrossRefPubMedWeb of Science
41. 41.↵
    1. Tyvaert L,
    2. Chassagnon S,
    3. Sadikot A, et al

    . Thalamic nuclei activity in idiopathic generalized epilepsy: an EEG-fMRI study. Neurology 2009;73:2018–22 doi:10.1212/WNL.0b013e3181c55d02 pmid:19996076

    Abstract/FREE Full Text
42. 42.↵
    1. Sisterson ND,
    2. Kokkinos V,
    3. Urban A, et al

    . Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: initial case series. J Neurol Neurosurg Psychiatry 2022;93:491–98 doi:10.1136/jnnp-2021-327512 pmid:35217517

    Abstract/FREE Full Text
43. 43.↵
    1. Welch WP,
    2. Hect JL,
    3. Abel TJ

    . Case report: responsive neurostimulation of the centromedian thalamic nucleus for the detection and treatment of seizures in pediatric primary generalized epilepsy. Front Neurol 2021;12:656585 doi:10.3389/fneur.2021.656585 pmid:33995254

    CrossRefPubMed