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Research ArticleBRAIN

Three-Dimensional, T1-Weighted Gradient-Echo Imaging of the Brain with a Volumetric Interpolated Examination

Stephan G. Wetzel, Glyn Johnson, Andrew G. S. Tan, Soonmee Cha, Edmond A. Knopp, Vivian S. Lee, David Thomasson and Neil M. Rofsky
American Journal of Neuroradiology June 2002, 23 (6) 995-1002;
Stephan G. Wetzel
aDepartment of Radiology, New York University Medical Center, NY
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Glyn Johnson
aDepartment of Radiology, New York University Medical Center, NY
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Andrew G. S. Tan
aDepartment of Radiology, New York University Medical Center, NY
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Soonmee Cha
aDepartment of Radiology, New York University Medical Center, NY
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Edmond A. Knopp
aDepartment of Radiology, New York University Medical Center, NY
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Vivian S. Lee
aDepartment of Radiology, New York University Medical Center, NY
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David Thomasson
bSiemens Medical Systems, Washington, DC
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Neil M. Rofsky
cMagnetic Resonance Imaging, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
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    Fig 1.

    SNR measurements obtained on a phantom for T1 values between 5 and 1000 ms for the 5-mm VIBE and MP RAGE reformations and the T1-weighted SE images.

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    Fig 2.

    Images of the posterior fossa in a patient with suspected metastatic disease. A, Two-dimensional T1-weighted SE image shows marked pulsation artifacts. Superimposition of the choroidal plexus in the fourth ventricle and the artifacts mimic a possible contrast-enhancing lesion (arrow). B, MP RAGE 5-mm reformation shows considerable ghost artifacts (arrows) impairing visualization of the pons and the cerebellum. C, VIBE 5-mm reformation shows no artifact.

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    Fig 3.

    Primary cerebral lymphoma. A–C, Interhemispheric contrast-enhancing lesion (arrow in A) is well visualized on both the 2D T1-weighted SE image (A) and the VIBE 5-mm reformation (B), but is less obvious on the MP RAGE 5-mm reformation (C).

Tables

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    TABLE 1:

    Summary of SNR and CNR Results

    ImagesSNRCNR
    GMWMGM-WMLesion-GMLesion-WM
    Source
     MP Rage23.1 ± 5.227.8 ± 5.04.8 ± 1.516.3 ± 10.211.8 ± 10.3
     VIBE26.1 ± 5.432.0 ± 6.35.9 ± 2.220.2 ± 11.314.3 ± 12.0
     P value.001<.001<.001.002.053
    5-mm Reformations
     MP RAGE73.8 ± 14.689.2 ± 15.115.4 ± 4.138.9 ± 26.325.1 ± 26.1
     VIBE77.5 ± 14.594.2 ± 16.316.8 ± 4.446.1 ± 26.430.0 ± 28.3
    T1-weighted SE96.1 ± 11.0106.4 ± 10.110.2 ± 4.964.1 ± 37.954.1 ± 39.1
     P value*<.001†<.001†<.001†<.001‡<.001†
    • Note.—Data are mean ratios ± SD.

    • ↵* P values are based on analysis of variance.

    • ↵† Paired Student t test demonstrated no significant difference between 5-mm VIBE and MP RAGE reformations.

    • ↵‡ Student t test demonstrated a statistically significant difference between each pairing of images obtained with the three imaging methods.

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    TABLE 2:

    Subjective artifact assessment

    ArtifactT1-Weighted SE ImagesVIBE 5-mm ReformationsMP RAGE 5-mm ReformationsP Value*
    Gross patient motion5.00 ± 0.04.98 ± 0.14.92 ± 0.20.039
    Flow-related3.73 ± 0.44.33 ± 0.64.02 ± 0.6<0.001†
    Ringing (truncation)4.25 ± 0.43.92 ± 0.43.83 ± 0.6<0.001‡
    • Note.—Data are mean grade ± SD. Grading scheme: 1, unreadable, nondiagnostic study; 2, severe artifacts, but diagnostic study; 3, moderate artifacts; 4, mild artifacts; 5, not encountered.

    • ↵* P values are based on analysis of variance.

    • ↵† Wilcoxon signed rank test demonstrated a statistically significant difference between each pairing of images obtained with the three imaging methods.

    • ↵‡ The Friedman nonparametric test showed significant differences between the three sequences considered together. However, the difference between MP RAGE and VIBE was not significant on the Wilcoxan signed rank sum test.

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    TABLE 3:

    Lesion Conspicuity by Imaging Technique

    Conspicuity Level and Lesion TypeT1-Weighted SEVIBEMP RAGE
    Best*
     Contrast-enhancing12.5 (14/11)8 (8/8)2.5 (1/4)
     All hyperintense20.5 (23/18)10 (9/11)3.5 (2/5)
    Intermediate*
     Contrast-enhancing4 (5/3)9 (10/8)10 (8/12)
     All hyperintense4.5 (5/4)15 (18/12)14.5 (11/18)
    Lowest*
     Contrast-enhancing6.5 (4/9)6 (5/7)10.5 (14/7)
     All hyperintense9 (6/12)9 (7/11)16 (21/11)
    Average rank†
     Contrast-enhancing1.7 (1.6/1.9)1.9 (1.9/2.0)2.4 (2.4/2.4)
     All hyperintense1.6 (1.6/1.9)2.0 (1.9/2.0)2.4 (2.6/2.2)
    • Note.—There were 34 hyperintense lesions of which 23 were contrast enhancing. Numbers in parentheses are separate results for the two readers.

    • ↵* Data are the average number of lesions.

    • ↵† Data are the average rank based on the ranking scheme 1 (best), 2 (intermediate), and 3 (worst).

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American Journal of Neuroradiology: 23 (6)
American Journal of Neuroradiology
Vol. 23, Issue 6
1 Jun 2002
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Cite this article
Stephan G. Wetzel, Glyn Johnson, Andrew G. S. Tan, Soonmee Cha, Edmond A. Knopp, Vivian S. Lee, David Thomasson, Neil M. Rofsky
Three-Dimensional, T1-Weighted Gradient-Echo Imaging of the Brain with a Volumetric Interpolated Examination
American Journal of Neuroradiology Jun 2002, 23 (6) 995-1002;

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Three-Dimensional, T1-Weighted Gradient-Echo Imaging of the Brain with a Volumetric Interpolated Examination
Stephan G. Wetzel, Glyn Johnson, Andrew G. S. Tan, Soonmee Cha, Edmond A. Knopp, Vivian S. Lee, David Thomasson, Neil M. Rofsky
American Journal of Neuroradiology Jun 2002, 23 (6) 995-1002;
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