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Research ArticleBRAIN

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: Structural MR Imaging Changes and Apolipoprotein E Genotype

R. van den Boom, S.A.J. Lesnick Oberstein, A.A. van den Berg-Huysmans, M.D. Ferrari, M.A. van Buchem and J. Haan
American Journal of Neuroradiology February 2006, 27 (2) 359-362;
R. van den Boom
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S.A.J. Lesnick Oberstein
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A.A. van den Berg-Huysmans
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M.D. Ferrari
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M.A. van Buchem
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J. Haan
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    Fig 1.

    Axial FLAIR (A–C) and T2*-weighted gradient (D) MR images of CADASIL patients. Complete MR imaging spectrum of CADASIL: confluent hyperintensities (A–C), lacunar infarcts (A, arrow), subcortical lacunar lesions (B, arrow), and microbleeds (D, arrow).

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  • MR imaging findings in apoE genotype subgroups

    All (n = 36)ε4 Allele Carriers (n = 8)Non-ε4 Allele Carriers (n = 28)95% CI of the Difference
    Age (y)44.9 (±11)47.5 (±7.9)44.2 (±11.7)−4.2–10.9
    Percentage white matter hyperintensities8.2 (±5.9)8.6 (±6.4)8.1 (±5.9)−5.1–6.0
    No. of lacunar infarcts8.8 (±12.6)13.1 (±14.7)7.5 (±11.9)−7.1–18.3
    No. of microbleeds*2.4 (±6.5)1.3 (±2.6)2.7 (±7.3)−4.8–1.9
    No. of persons with subcortical lacunar infarcts18 (50%)4 (50%)14 (50%)
    • There is no significant difference in MR imaging findings between ε4 allele carriers and nonε4 allele carriers.

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American Journal of Neuroradiology: 27 (2)
American Journal of Neuroradiology
Vol. 27, Issue 2
February, 2006
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Cite this article
R. van den Boom, S.A.J. Lesnick Oberstein, A.A. van den Berg-Huysmans, M.D. Ferrari, M.A. van Buchem, J. Haan
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: Structural MR Imaging Changes and Apolipoprotein E Genotype
American Journal of Neuroradiology Feb 2006, 27 (2) 359-362;

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Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: Structural MR Imaging Changes and Apolipoprotein E Genotype
R. van den Boom, S.A.J. Lesnick Oberstein, A.A. van den Berg-Huysmans, M.D. Ferrari, M.A. van Buchem, J. Haan
American Journal of Neuroradiology Feb 2006, 27 (2) 359-362;
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