Article Figures & Data
Figures
- Fig 1.
T1-weighted midsagittal images obtained at baseline visit in an 8.6-year old healthy girl (A), a 10.2-year old boy with ALL (B), and an 8.5-year old girl diagnosed with medulloblastoma (C, surgical resection included the posterior vermis).
- Fig 2.
Relative lobar vermal volumes in healthy children and patients with brain malignancies. Patients tended to have lower relative vermal volumes even before the start of the radiation treatment. The volumes of the posterior vermis, lobules VIII-X, were the lowest in 3 patients with medulloblastoma treated by surgical resection, which involved removing parts of cerebellar tissue. The lines connect data from individual subjects; asterisks indicate patients with medulloblastoma.
- Fig 3.
Relationship between percentage changes in relative lobar vermal volumes and corresponding radiation doses. Results of linear regression analyses are shown. The decrease in anterior and posterior vermal volumes was the highest in the patients with medulloblastoma (labeled with asterisks) who were treated with the highest radiation doses to the vermis (in addition to surgery and chemotherapy).
- Fig 4.
Standard scores of the WJ-III Visual Matching test and z scores of the Purdue Pegboard both hands, right hand, and left hand tests in healthy children and patients with brain malignancies. Low test scores in patients indicate impairment in visual selective attention, processing speed, and manipulative dexterity. The lines connect data from individual subjects. Asterisks indicate patients with medulloblastoma.
- Fig 5.
Relationship between z scores of the Purdue Pegboard Tests and total relative vermal volumes at the 6-month follow-up visit. Results of linear regression analyses are presented. Low vermal volumes in patients with medulloblastoma (labeled with asterisks) were associated with poor performance on the Purdue Pegboard Tests. Filled circles indicate patients; open circles indicate controls.
Tables
Patient demographic and clinical information
Patient No. Sex Age (yr) Diagnosis Tumor Location Treatment Prior to RT (Time of Administration before RT, mo)a Radiation Dose (Gy) Anterior Posterior Surgery Chemotherapy Steroids I-V VI-VII VIII-X 1 M 5.5 Pilocytic astrocytoma Right frontal suprasellar/optic Yes (42.7) CaPt (35.0), TMZ (16.5) No 18.5 20.4 23.5 2b F 8.5 Anaplastic medulloblastoma Posterior fossa Yes (5.8) CsPt/VP-16/ CTX/VCR/MTX (5.2) Dex (5.3) 54.4 54.3 54.3 3 F 8.7 Nonanaplastic medulloblastoma Posterior fossa Yes (1.1) No Dex (0.8) 54.0 54.0 54.0 4b M 9.2 Anaplastic medulloblastoma Fourth ventricle Yes (1.5) No Dex (1.5) 54.5 54.5 54.5 5 M 10.2 T-cell ALL No tumor No T-cell IC (1.1) Pred (0.7) 18.3 18.3 18.3 6 M 11.8 Nondiagnostic biopsy (astrocytoma or ependymoma) Pineal No (VP shunt) No No 14.9 4.8 30.0 7 M 11.8 Malignant glioneuronal tumor, otherwise unclassifiable Left frontal Yes (5.7) No No 41.4 41.0 34.5 8 M 15.3 Ependymoma Left medial temporal lobe Yes (0.9) No No 36.7 36. 8 38.0 9b M 16.0 Pontine glioma Pons No No Dex (2.0) 50.6 24.7 33.1 10 F 18.6 Germinoma Suprasellar Yes (4.1) CsPt/VP-16/ CTX/VCR/(3.1) HC (3.7) 20.3 15.4 16.0 Note:—In all patients with medulloblastoma, the posterior vermis was affected by surgery. None of the patients were diagnosed with obstructive hydrocephalus; moderately enlarged ventricles were noted in patients 1 and 6. Postsurgical mutism was diagnosed in patient 3.
a Time of administration before the start of radiation treatment is shown.
b Patient died.
