Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR is seeking candidates for the AJNR Podcast Editor. Read the position description.

Research ArticlePEDIATRICS

Modeling Early Postnatal Brain Growth and Development with CT: Changes in the Brain Radiodensity Histogram from Birth to 2 Years

K.A. Cauley, Y. Hu, J. Och, P.J. Yorks and S.W. Fielden
American Journal of Neuroradiology April 2018, 39 (4) 775-781; DOI: https://doi.org/10.3174/ajnr.A5559
K.A. Cauley
aFrom the Department of Radiology (K.A.C., S.W.F.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K.A. Cauley
Y. Hu
bBiomedical & Translational Informatics (Y.H.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Y. Hu
J. Och
cDepartment of Medical & Health Physics (J.O., P.J.Y.), Geisinger Health System, Danville, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Och
P.J. Yorks
cDepartment of Medical & Health Physics (J.O., P.J.Y.), Geisinger Health System, Danville, Pennsylvania
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for P.J. Yorks
S.W. Fielden
aFrom the Department of Radiology (K.A.C., S.W.F.)
dDepartment of Imaging Science & Innovation (S.W.F.), Geisinger Health System, Lewisburg, Pennsylvania.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.W. Fielden
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    CT Accreditation Program: Testing Instructions. Revised January 6, 2017. https://www.acraccreditation.org/∼/media/ACRAccreditation/Documents/CT/CT-Accreditation-Testing-Instructions.pdf. Accessed August 15, 2017,
  2. 2.↵
    1. Zhang Y,
    2. Brady M,
    3. Smith S
    . Segmentation of brain MR images through a hidden Markov random field model and the expectation-maximization algorithm. IEEE Trans Med Imaging 2001;20:45–57 doi:10.1109/42.906424 pmid:11293691
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Jenkinson M,
    2. Beckmann CF,
    3. Behrens TE, et al
    . FSL. Neuroimage 2012;62:782–90 doi:10.1016/j.neuroimage.2011.09.015 pmid:21979382
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Muschelli J,
    2. Ullman NL,
    3. Mould WA, et al
    . Validated automatic brain extraction of head CT images. Neuroimage 2015;114:379–85 doi:10.1016/j.neuroimage.2015.03.074 pmid:25862260
    CrossRefPubMed
  5. 5.↵
    1. Cauley KA,
    2. Och J,
    3. Yorks PJ, et al
    . Automated segmentation of head computed tomography images using FSL. J Comput Assist Tomogr 2018;42:104–10 doi:10.1097/RCT.0000000000000660 pmid:28786900
    CrossRefPubMed
  6. 6.↵
    1. Castellanos FX,
    2. Lee PP,
    3. Sharp W, et al
    . Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA 2002;288:1740–48 doi:10.1001/jama.288.14.1740 pmid:12365958
    CrossRefPubMedWeb of Science
  7. 7.↵
    R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2014. http://www.R-project.org/. Accessed January 3, 2015.
  8. 8.↵
    1. Holland D,
    2. Chang L,
    3. Ernst TM, et al
    . Structural growth trajectories and rates of change in the first 3 months of infant brain development. JAMA Neurol 2014;71:1266–74 doi:10.1001/jamaneurol.2014.1638 pmid:25111045
    CrossRefPubMed
  9. 9.↵
    1. Hüppi PS,
    2. Warfield S,
    3. Kikinis R, et al
    . Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann Neurol 1998;43:224–35 doi:10.1002/ana.410430213 pmid:9485064
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Brant-Zawadzki M,
    2. Enzmann DR
    . Using computed tomography of the brain to correlate low white-matter attenuation with early gestational age in neonates. Radiology 1981;139:105–08 doi:10.1148/radiology.139.1.7208910 pmid:7208910
    CrossRefPubMed
  11. 11.↵
    1. Choe MS,
    2. Ortiz-Mantilla S,
    3. Makris N, et al
    . Regional infant brain development: an MRI-based morphometric analysis in 3 to 13 month olds. Cereb Cortex 2013;23:2100–17 doi:10.1093/cercor/bhs197 pmid:22772652
    CrossRefPubMedWeb of Science
  12. 12.↵
    1. Knickmeyer RC,
    2. Gouttard S,
    3. Kang C, et al
    . A structural MRI study of human brain development from birth to 2 years. J Neurosci 2008;28:12176–82 doi:10.1523/JNEUROSCI.3479-08.2008 pmid:19020011
    Abstract/FREE Full Text
  13. 13.↵
    1. Penn RD,
    2. Trinko B,
    3. Baldwin L
    . Brain maturation followed by computed tomography. J Comput Assist Tomogr 1980;4:614–16 doi:10.1097/00004728-198010000-00007 pmid:7410638
    CrossRefPubMed
  14. 14.↵
    1. Pfefferbaum A,
    2. Mathalon DH,
    3. Sullivan EV, et al
    . A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 1994;51:874–87 doi:10.1001/archneur.1994.00540210046012 pmid:8080387
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Zhang L,
    2. Thomas KM,
    3. Davidson MC, et al
    . MR quantitation of volume and diffusion changes in the developing brain. AJNR Am J Neuroradiol 2005;26:45–49 pmid:15661698
    Abstract/FREE Full Text
  16. 16.↵
    1. Proal E,
    2. Reiss PT,
    3. Klein RG, et al
    . Brain gray matter deficits at 33-year follow-up in adults with attention-deficit/hyperactivity disorder established in childhood. Arch Gen Psychiatry 2011;68:1122–34 doi:10.1001/archgenpsychiatry.2011.117 pmid:22065528
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Petropoulos H,
    2. Friedman SD,
    3. Shaw DW, et al
    . Gray matter abnormalities in autism spectrum disorder revealed by T2 relaxation. Neurology 2006;67:632–36 doi:10.1212/01.wnl.0000229923.08213.1e pmid:16924017
    Abstract/FREE Full Text
  18. 18.↵
    1. Courchesne E,
    2. Karns CM,
    3. Davis HR, et al
    . Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 2001;57:245–54 doi:10.1212/WNL.57.2.245 pmid:11468308
    Abstract/FREE Full Text
  19. 19.↵
    1. Lei W,
    2. Deng W,
    3. Li M, et al
    . Gray matter volume alterations in first-episode drug-naive patients with deficit and nondeficit schizophrenia. Psychiatry Res 2015;234:219–26 doi:10.1016/j.pscychresns.2015.09.015 pmid:26409573
    CrossRefPubMed
  20. 20.↵
    1. Hamano K,
    2. Iwasaki N,
    3. Kawashima K, et al
    . Volumetric quantification of brain volume in children using sequential CT scans. Neuroradiology 1990;32:300–03 doi:10.1007/BF00593049 pmid:2234389
    CrossRefPubMed
  21. 21.↵
    1. Shi F,
    2. Yap PT,
    3. Wu G, et al
    . Infant brain atlases from neonates to 1- and 2-year-olds. PLoS One 2011;6:e18746 doi:10.1371/journal.pone.0018746 pmid:21533194
    CrossRefPubMed
  22. 22.↵
    1. Dobbing J,
    2. Sands J
    . Quantitative growth and development of human brain. Arch Dis Child 1973;48:757–67 doi:10.1136/adc.48.10.757 pmid:4796010
    Abstract/FREE Full Text
  23. 23.↵
    1. Gilmore JH,
    2. Lin W,
    3. Prastawa MW, et al
    . Regional gray matter growth, sexual dimorphism, and cerebral asymmetry in the neonatal brain. J Neurosci 2007;27:1255–60 doi:10.1523/JNEUROSCI.3339-06.2007 pmid:17287499
    Abstract/FREE Full Text
  24. 24.↵
    1. Matsuzawa J,
    2. Matsui M,
    3. Konishi T, et al
    . Age-related volumetric changes of brain gray and white matter in healthy infants and children. Cereb Cortex 2001;11:335–42 doi:10.1093/cercor/11.4.335 pmid:11278196
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Allen JS,
    2. Damasio H,
    3. Grabowski TJ
    . Normal neuroanatomical variation in the human brain: an MRI-volumetric study. Am J Phys Anthropol 2002;118:341–58 doi:10.1002/ajpa.10092 pmid:12124914
    CrossRefPubMedWeb of Science
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 39 (4)
American Journal of Neuroradiology
Vol. 39, Issue 4
1 Apr 2018
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Modeling Early Postnatal Brain Growth and Development with CT: Changes in the Brain Radiodensity Histogram from Birth to 2 Years
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
K.A. Cauley, Y. Hu, J. Och, P.J. Yorks, S.W. Fielden
Modeling Early Postnatal Brain Growth and Development with CT: Changes in the Brain Radiodensity Histogram from Birth to 2 Years
American Journal of Neuroradiology Apr 2018, 39 (4) 775-781; DOI: 10.3174/ajnr.A5559

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Modeling Early Postnatal Brain Growth and Development with CT: Changes in the Brain Radiodensity Histogram from Birth to 2 Years
K.A. Cauley, Y. Hu, J. Och, P.J. Yorks, S.W. Fielden
American Journal of Neuroradiology Apr 2018, 39 (4) 775-781; DOI: 10.3174/ajnr.A5559
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Head CT: Toward Making Full Use of the Information the X-Rays Give
  • Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
  • Aging and the Brain: A Quantitative Study of Clinical CT Images
  • Crossref (8)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Biochemical Changes Indicate Developmental Stage in the Hippocampal Formation
    Joanna G. Chwiej, Stanislaw W. Ciesielka, Agnieszka K. Skoczen, Krzysztof J. Janeczko, Christophe Sandt, Karolina L. Planeta, Zuzanna K. Setkowicz
    ACS Chemical Neuroscience 2019 10 1
  • Aging and the Brain: A Quantitative Study of Clinical CT Images
    K.A. Cauley, Y. Hu, S.W. Fielden
    American Journal of Neuroradiology 2020 41 5
  • Head CT: Toward Making Full Use of the Information the X-Rays Give
    K.A. Cauley, Y. Hu, S.W. Fielden
    American Journal of Neuroradiology 2021 42 8
  • Zika virus vertical transmission in interferon receptor1-antagonized Rag1−/− mice results in postnatal brain abnormalities and clinical disease
    Clayton W. Winkler, Chad S. Clancy, Rebecca Rosenke, Karin E. Peterson
    Acta Neuropathologica Communications 2022 10 1
  • Pitfalls in the interpretation of pediatric head CTs: what the emergency radiologist needs to know
    Hannah Hodges, Katherine N. Epstein, Michele Retrouvey, Sherry S. Wang, Allyson A. Richards, Dustin Lima, Jonathan W. Revels
    Emergency Radiology 2022 29 4
  • The effects of the skull on CT imaging of the brain: a skull and brain phantom study
    Keith A Cauley, Patrick J Yorks, Sarah Flora, Samuel W Fielden
    The British Journal of Radiology 2021 94 1119
  • Pediatric Head CT: Automated Quantitative Analysis with Quantile Regression
    K.A. Cauley, Y. Hu, S.W. Fielden
    American Journal of Neuroradiology 2021 42 2
  • Automatic segmentation and quantitative analysis of brain CT volume in 2-year-olds using deep learning model
    Fengjun Xi, Liyun Tu, Feng Zhou, Yanjie Zhou, Jun Ma, Yun Peng
    Frontiers in Neurology 2025 16

More in this TOC Section

  • SyMRI & MR Fingerprinting in Brainstem Myelination
  • Comparison of Image Quality and Radiation Dose in Pediatric Temporal Bone CT Using Photon-Counting Detector CT and Energy-Integrating Detector CT
  • Dandy-Walker Phenotype with Brainstem Involvement
Show more Pediatrics

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • AJNR Awards
  • ASNR Foundation Special Collection
  • Most Impactful AJNR Articles
  • Photon-Counting CT
  • Spinal CSF Leak Articles (Jan 2020-June 2024)

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire