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Research ArticleAdult Brain
Open Access

Cluster Analysis of DSC MRI, Dynamic Contrast-Enhanced MRI, and DWI Parameters Associated with Prognosis in Patients with Glioblastoma after Removal of the Contrast-Enhancing Component: A Preliminary Study

H. Chung, H. Seo, S.H. Choi, C.-K. Park, T.M. Kim, S.-H. Park, J.K. Won, J.H. Lee, S.-T. Lee, J.Y. Lee, I. Hwang, K.M. Kang and T.J. Yun
American Journal of Neuroradiology November 2022, 43 (11) 1559-1566; DOI: https://doi.org/10.3174/ajnr.A7655
H. Chung
aFrom the Seoul National University College of Medicine (H.C., H.S.), Seoul, Korea
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H. Seo
aFrom the Seoul National University College of Medicine (H.C., H.S.), Seoul, Korea
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S.H. Choi
bDepartment of Radiology (S.H.C., J.Y.L., I.H., K.M.K., T.J.Y.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
cCenter for Nanoparticle Research (S.H.C.), Institute for Basic Science, Seoul, Korea
dSchool of Chemical and Biological Engineering (S.H.C.), Seoul National University, Seoul, Korea
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C.-K. Park
eDepartment of Neurosurgery (C.-K.P.), Internal Medicine
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T.M. Kim
fCancer Research Institute (T.M.K.)
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S.-H. Park
gDepartments of Pathology (S.-H.P., J.K.W.), Radiation Oncology
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J.K. Won
gDepartments of Pathology (S.-H.P., J.K.W.), Radiation Oncology
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J.H. Lee
hCancer Research Institute (J.H.L.)
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S.-T. Lee
iNeurology (S.-T.L.), Seoul National University Hospital, Seoul, Korea
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J.Y. Lee
bDepartment of Radiology (S.H.C., J.Y.L., I.H., K.M.K., T.J.Y.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
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I. Hwang
bDepartment of Radiology (S.H.C., J.Y.L., I.H., K.M.K., T.J.Y.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
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K.M. Kang
bDepartment of Radiology (S.H.C., J.Y.L., I.H., K.M.K., T.J.Y.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
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T.J. Yun
bDepartment of Radiology (S.H.C., J.Y.L., I.H., K.M.K., T.J.Y.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
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References

  1. 1.↵
    1. Silantyev AS,
    2. Falzone L,
    3. Libra M, et al
    . Current and future trends on diagnosis and prognosis of glioblastoma: from molecular biology to proteomics. Cells 2019;8:863 doi:10.3390/cells8080863 pmid:31405017
    CrossRefPubMed
  2. 2.
    1. Thakkar JP,
    2. Dolecek TA,
    3. Horbinski C, et al
    . Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev 2014;23:1985–96 doi:10.1158/1055-9965.EPI-14-0275 pmid:25053711
    Abstract/FREE Full Text
  3. 3.↵
    1. Louis DN,
    2. Perry A,
    3. Reifenberger G, et al
    . The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 2016;131:803–20 doi:10.1007/s00401-016-1545-1 pmid:27157931
    CrossRefPubMed
  4. 4.↵
    1. Hardesty DA,
    2. Sanai N
    . The value of glioma extent of resection in the modern neurosurgical era. Front Neurol 2012;3:140 doi:10.3389/fneur.2012.00140 pmid:23087667
    CrossRefPubMed
  5. 5.↵
    1. Weller M,
    2. van den Bent M,
    3. Tonn JC, et al
    ; European Association for Neuro-Oncology (EANO) Task Force on Gliomas. European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas. Lancet Oncol 2017;18:e315–29 doi:10.1016/S1470-2045(17)30194-8 pmid:28483413
    CrossRefPubMed
  6. 6.↵
    1. Omuro A,
    2. DeAngelis LM
    . Glioblastoma and other malignant gliomas: a clinical review. JAMA 2013;310:1842–50 doi:10.1001/jama.2013.280319 pmid:24193082
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Lasocki A,
    2. Gaillard F
    . Non-contrast-enhancing tumor: a new frontier in glioblastoma research. AJNR Am J Neuroradiol 2019;40:758–65 doi:10.3174/ajnr.A6025 pmid:30948373
    Abstract/FREE Full Text
  8. 8.
    1. Grabowski MM,
    2. Recinos PF,
    3. Nowacki AS, et al
    . Residual tumor volume versus extent of resection: predictors of survival after surgery for glioblastoma. J Neurosurg 2014;121:1115–23 doi:10.3171/2014.7.JNS132449 pmid:25192475
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Jain R,
    2. Poisson LM,
    3. Gutman D, et al
    . Outcome prediction in patients with glioblastoma by using imaging, clinical, and genomic biomarkers: focus on the nonenhancing component of the tumor. Radiology 2014;272:484–93 doi:10.1148/radiol.14131691 pmid:24646147
    CrossRefPubMed
  10. 10.↵
    1. Jain R
    . Measurements of tumor vascular leakiness using DCE in brain tumors: clinical applications. NMR Biomed 2013;26:1042–49 doi:10.1002/nbm.2994 pmid:23832526
    CrossRefPubMed
  11. 11.↵
    1. Heye AK,
    2. Culling RD,
    3. Valdes HM, et al
    . Assessment of blood-brain barrier disruption using dynamic contrast-enhanced MRI: a systematic review. Neuroimage Clin 2014;6:262– 74 doi:10.1016/j.nicl.2014.09.002 pmid:25379439
    CrossRefPubMed
  12. 12.↵
    1. Thompson G,
    2. Mills SJ,
    3. Coope DJ, et al
    . Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours. Br J Radiol 2011;84(Spec No 2):S127–44 doi:10.1259/bjr/66316279 pmid:22433824
    Abstract/FREE Full Text
  13. 13.↵
    1. Koh DM,
    2. Collins DJ
    . Diffusion-weighted MRI in the body: applications and challenges in oncology. AJR Am J Roentgenol 2007;188:1622–35 doi:10.2214/AJR.06.1403 pmid:17515386
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Kourou K,
    2. Exarchos TP,
    3. Exarchos KP, et al
    . Machine learning applications in cancer prognosis and prediction. Comput Struct Biotechnol J 2015;13:8–17 doi:10.1016/j.csbj.2014.11.005 pmid:25750696
    CrossRefPubMed
  15. 15.↵
    1. Heiss WD,
    2. Raab P,
    3. Lanfermann H
    . Multimodality assessment of brain tumors and tumor recurrence. J Nucl Med 2011;52:1585–1600 doi:10.2967/jnumed.110.084210 pmid:21840931
    Abstract/FREE Full Text
  16. 16.↵
    1. Macyszyn L,
    2. Akbari H,
    3. Pisapia JM, et al
    . Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques. Neuro Oncol 2016;18:417–25 doi:10.1093/neuonc/nov127 pmid:26188015
    CrossRefPubMed
  17. 17.↵
    1. Kang Y,
    2. Hong EK,
    3. Rhim JH, et al
    . Prognostic value of dynamic contrast-enhanced MRI-derived pharmacokinetic variables in glioblastoma patients: analysis of contrast-enhancing lesions and non-enhancing T2 high-signal intensity lesions. Korean J Radiol 2020;21:707–16 doi:10.3348/kjr.2019.0629 pmid:32410409
    CrossRefPubMed
  18. 18.↵
    1. Ashabi A,
    2. Sahibuddin SB,
    3. Haghighi MS
    . The systematic review of K-means clustering algorithm. In: Proceedings of the 9th International Conference on Networks, Communication and Computing, Tokyo, Japan. December 18–20, 2020:13–18 doi:10.1145/3447654.3447657
  19. 19.↵
    1. Barnes SR,
    2. Ng TS,
    3. Montagne A, et al
    . Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med 2016;75:1967–77 doi:10.1002/mrm.25793 pmid:26077645
    CrossRefPubMed
  20. 20.↵
    1. Jain R,
    2. Griffith B,
    3. Alotaibi F, et al
    . Glioma angiogenesis and perfusion imaging: understanding the relationship between tumor blood volume and leakiness with increasing glioma grade. AJNR Am J Neuroradiol 2015;36:2030–35 doi:10.3174/ajnr.A4405 pmid:26206809
    Abstract/FREE Full Text
  21. 21.↵
    1. Lee EJ,
    2. terBrugge K,
    3. Mikulis D, et al
    . Diagnostic value of peritumoral minimum apparent diffusion coefficient for differentiation of glioblastoma multiforme from solitary metastatic lesions. AJR Am J Roentgenol 2011;196:71–76 doi:10.2214/AJR.10.4752 pmid:21178049
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Chiang IC,
    2. Kuo YT,
    3. Lu CY, et al
    . Distinction between high-grade gliomas and solitary metastases using peritumoral 3-T magnetic resonance spectroscopy, diffusion, and perfusion imagings. Neuroradiology 2004;46:619–27 doi:10.1007/s00234-004-1246-7 pmid:15243726
    CrossRefPubMedWeb of Science
  23. 23.↵
    1. Yang L,
    2. Lin C,
    3. Wang L, et al
    . Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications. Exp Cell Res 2012;318:2417–26 doi:10.1016/j.yexcr.2012.07.017 pmid:22906859
    CrossRefPubMedWeb of Science
  24. 24.
    1. Kaur B,
    2. Khwaja FW,
    3. Severson EA, et al
    . Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis. Neuro Oncol 2005;7:134–53 doi:10.1215/S1152851704001115 pmid:15831232
    CrossRefPubMed
  25. 25.↵
    1. Monteiro AR,
    2. Hill R,
    3. Pilkington GJ, et al
    . The role of hypoxia in glioblastoma invasion. Cells 2017;6:45 doi:10.3390/cells6040045 pmid:29165393
    CrossRefPubMed
  26. 26.↵
    1. Rong Y,
    2. Durden DL,
    3. Van Meir EG, et al
    . “Pseudopalisading” necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis. J Neuropathol Exp Neurol 2006;65:529–39 doi:10.1097/00005072-200606000-00001 pmid:16783163
    CrossRefPubMed
  27. 27.↵
    1. Kim R,
    2. Choi SH,
    3. Yun TJ, et al
    . Prognosis prediction of non-enhancing T2 high signal intensity lesions in glioblastoma patients after standard treatment: application of dynamic contrast-enhanced MR imaging. Eur Radiol 2017;27:1176–85 doi:10.1007/s00330-016-4464-6 pmid:27357131
    CrossRefPubMed
  28. 28.↵
    1. Brat DJ,
    2. Castellano-Sanchez AA,
    3. Hunter SB, et al
    . Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population. Cancer Res 2004;64:920–27 doi:10.1158/0008-5472.CAN-03-2073 pmid:14871821
    Abstract/FREE Full Text
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American Journal of Neuroradiology: 43 (11)
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H. Chung, H. Seo, S.H. Choi, C.-K. Park, T.M. Kim, S.-H. Park, J.K. Won, J.H. Lee, S.-T. Lee, J.Y. Lee, I. Hwang, K.M. Kang, T.J. Yun
Cluster Analysis of DSC MRI, Dynamic Contrast-Enhanced MRI, and DWI Parameters Associated with Prognosis in Patients with Glioblastoma after Removal of the Contrast-Enhancing Component: A Preliminary Study
American Journal of Neuroradiology Nov 2022, 43 (11) 1559-1566; DOI: 10.3174/ajnr.A7655

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DSC MRI and DWI Prognosis in Glioblastoma
H. Chung, H. Seo, S.H. Choi, C.-K. Park, T.M. Kim, S.-H. Park, J.K. Won, J.H. Lee, S.-T. Lee, J.Y. Lee, I. Hwang, K.M. Kang, T.J. Yun
American Journal of Neuroradiology Nov 2022, 43 (11) 1559-1566; DOI: 10.3174/ajnr.A7655
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