Article Figures & Data
Figures
- FIG 1.
An example of hippocampal subfield segmentation by FreeSurfer (upper row) and volBrain (lower row) shown in axial, coronal, and sagittal sections. GC-ML-DG indicates granule cell and molecular layers of the dentate gyrus; HATA, hippocampus-amygdala transition area.
- FIG 2.
A, Comparison of uncorrected total hippocampus, CA1, CA2-CA3, CA4-DG, and subiculum volumes (cubic millimeters) between FreeSurfer and volBrain (yellow, women; blue, men). Regression lines relating volBrain to FreeSurfer volumes are shown for each subfield. The average values of subfield volumes reported here are the sum of right and left hemisphere volumes combined. All Pearson r correlations are significant (P < .001). B, Bar graphs show means (SDs). Double asterisks indicate statistical significance (P < .001); FS, FreeSurfer; VB, volBrain.
- FIG 3.
Bland-Altman plots for uncorrected subfield volumes (CA1, CA2-CA3, CA4-DG, and subiculum volumes [cubic millimeters]) generated by FreeSurfer and volBrain (yellow, women; blue, men). Intrasubject volume difference (y-axis) is defined as (FreeSurfer volume) – (volBrain volume). Mean volume is represented on the x-axis. The mean (SD, 1.96) volume difference and 95% confidence intervals are plotted as dashed horizontal lines. Except for the subiculum, all Pearson r correlations are significant (P < .001).
Tables
Uncorrected hippocampal subfield, total hippocampal, and intracranial volumes measured by FreeSurfer and volBrain protocolsa
Total (n = 172) Male (n = 83) Female (n = 89) Cohen’s D Mean SD Mean SD Mean SD FreeSurfer v6.0 CA1 1251 193 1321 169 1184 159 0.83 CA2-CA3 472 71 497 51 449 54 0.91 CA4-DG 1113 171 1173 141 1057 135 0.84 Subiculum 807 102 841 101 775 87 0.7 Parasubiculum 121 21 126 16 117 21 0.48 Presubiculum 553 72 581 75 527 59 0.8 Molecular layer 1205 168 1241 136 1172 150 0.48 HATA 136 31 142 19 130 23 0.57 Fimbria 178 67 188 62 168 48 0.36 Tail 999 160 1049 155 952 118 0.7 Fissureb 269 71 276 49 262 70 0.23 THV 6839 957 7163 846 6537 758 0.78 eICV 1,563,261 146,983 1,677,235 158,967 1,456,885 231,310 1.11 volBrain, HIPS segmentation protocol CA1 1486 286 1574 267 1405 234 0.67 CA2-CA3 264 37 276 43 253 32 0.61 CA4-DG 1420 221 1462 207 1382 260 0.34 SR-SL-SM 938 158 988 173 892 145 0.6 Subiculum 566 87 593 86 541 93 0.58 THV 4689 771 4908 776 4484 665 0.59 eICV 1,374,768 133,467 1,462,729 139,905 1,292,671 126,129 1.28 Note:—HATA indicates hippocampus-amygdala transition area; eICV, estimated intracranial volume; HIPS, hippocampal subfield segmentation protocol.
↵a Uuits are cubic millimeters.
↵b Not significantly different. Men had significantly larger values than females in all volumes, except hippocampus fissure (P < .05, Student t test). The average values of total and subfield volumes reported here are the sum of right and left hemispheres combined.
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