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Abstract

Heparin administration and monitoring for neuroangiography.

Y Fujii, S Takeuchi, T Koike, K Nishimaki, Y Ito, R Tanaka and K Okamoto
American Journal of Neuroradiology January 1994, 15 (1) 51-54;
Y Fujii
Department of Neurosurgery, Niigata University, Japan.
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S Takeuchi
Department of Neurosurgery, Niigata University, Japan.
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T Koike
Department of Neurosurgery, Niigata University, Japan.
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K Nishimaki
Department of Neurosurgery, Niigata University, Japan.
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Y Ito
Department of Neurosurgery, Niigata University, Japan.
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R Tanaka
Department of Neurosurgery, Niigata University, Japan.
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K Okamoto
Department of Neurosurgery, Niigata University, Japan.
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Abstract

PURPOSE To establish the optimal protocol of heparin administration during interventional neuroradiology.

METHODS We assessed 100 cases of neuroangiography, including endovascular surgery, and measured activated coagulation time before and 5 minutes after heparin administration, and before and 5 minutes after protamine neutralization. In some cases actual heparin concentration was assayed using a chromogenic substrate technique.

RESULTS The actual plasma heparin concentration significantly correlated with the dose of heparin administered intravenously (r = .98; P < .0001) and changes in activated coagulation time (r = .85; P < .0001). The change in activated coagulation time significantly correlated with the dose of heparin injected intravenously (r = .54, P < .0001). The ratio of change in activated coagulation time significantly correlated with time elapsed after heparin administration (r = -.70, P < .0001).

CONCLUSIONS The activated coagulation time is useful in monitoring administration and neutralization of heparin during neuroangiography, and a bolus injection of 60 U/kg heparin should be adequate to carry out neuroangiography for 75 minutes safely, even for endovascular surgery.

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American Journal of Neuroradiology
Vol. 15, Issue 1
1 Jan 1994
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Y Fujii, S Takeuchi, T Koike, K Nishimaki, Y Ito, R Tanaka, K Okamoto
Heparin administration and monitoring for neuroangiography.
American Journal of Neuroradiology Jan 1994, 15 (1) 51-54;

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Heparin administration and monitoring for neuroangiography.
Y Fujii, S Takeuchi, T Koike, K Nishimaki, Y Ito, R Tanaka, K Okamoto
American Journal of Neuroradiology Jan 1994, 15 (1) 51-54;
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