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Research ArticleINTERVENTIONAL

Brain Single-photon Emission CT Studies Using 99mTc-HMPAO and 99mTc-ECD Early after Recanalization by Local Intraarterial Thrombolysis in Patients with Acute Embolic Middle Cerebral Artery Occlusion

Kuniaki Ogasawara, Akira Ogawa, Masayuki Ezura, Hiromu Konno, Michiyasu Suzuki and Takashi Yoshimoto
American Journal of Neuroradiology January 2001, 22 (1) 48-53;
Kuniaki Ogasawara
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Akira Ogawa
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Masayuki Ezura
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Hiromu Konno
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Michiyasu Suzuki
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Takashi Yoshimoto
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    fig 1.

    Schematic presentation of the protocol for SPECT; x axis is time (min) and y axis is decay-corrected regional counts

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    fig 2.

    Outcome versus posttreatment SPECT findings of both tracers. Count densities of the ROIs on the affected side were classified as hypoactivity, hyperactivity, or isoactivity if the A/C ratio was below 0.9, above 1.1, or 0.9 to 1.1, respectively. Open circles represent noninfarction; gray circles, infarction; black circles, hemorrhage

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    fig 3.

    Patient 6: 58-year-old man with left-sided MCA occlusion.

    A, Pretreatment 99mTc-HMPAO SPECT scan shows a perfusion defect in the left MCA territory.

    B, Posttreatment 99mTc-HMPAO (left) and 99mTc-ECD (right) SPECT scans obtained 2.5 hours after recanalization by LIT.

    C, MR image 2 weeks after the onset of stroke. Infarction did not develop in ROI 2, which showed hyperactivity (A/C ratio of 1.14) on 99mTc-HMPAO SPECT scan and isoactivity (A/C ratio of 0.97) on 99mTc-ECD SPECT scan. In ROI 1, however, which showed hypoactivity (A/C ratio of 0.85) on 99mTc-ECD SPECT scan, infarction did develop despite isoactivity (A/C ratio of 1.06) on 99mTc-HMPAO SPECT scan.

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    fig 4.

    Patient 8: 61-year-old man with right-sided MCA occlusion.

    A, Posttreatment 99mTc-HMPAO (left) and 99mTc-ECD (right) SPECT scans obtained 2 hours after recanalization by LIT.

    B, CT scan 30 hours after the onset of stroke. Hemorrhagic transformation with ischemic brain edema developed in ROI 3, which showed hyperactivity (A/C ratio of 1.36) on 99mTc-HMPAO SPECT scan and hypoactivity (A/C ratio of 0.85) on 99mTc-ECD SPECT scan.

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    Summary of patients with embolic middle cerebral artery occlusion treated by local intraarterial thrombolysis

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American Journal of Neuroradiology
Vol. 22, Issue 1
1 Jan 2001
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Cite this article
Kuniaki Ogasawara, Akira Ogawa, Masayuki Ezura, Hiromu Konno, Michiyasu Suzuki, Takashi Yoshimoto
Brain Single-photon Emission CT Studies Using 99mTc-HMPAO and 99mTc-ECD Early after Recanalization by Local Intraarterial Thrombolysis in Patients with Acute Embolic Middle Cerebral Artery Occlusion
American Journal of Neuroradiology Jan 2001, 22 (1) 48-53;

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Brain Single-photon Emission CT Studies Using 99mTc-HMPAO and 99mTc-ECD Early after Recanalization by Local Intraarterial Thrombolysis in Patients with Acute Embolic Middle Cerebral Artery Occlusion
Kuniaki Ogasawara, Akira Ogawa, Masayuki Ezura, Hiromu Konno, Michiyasu Suzuki, Takashi Yoshimoto
American Journal of Neuroradiology Jan 2001, 22 (1) 48-53;
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