Research ArticleBRAIN
Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part I: Volumetric MR Imaging Analysis
Yulin Ge, Robert I. Grossman, James S. Babb, Marcie L. Rabin, Lois J. Mannon and Dennis L. Kolson
American Journal of Neuroradiology September 2002, 23 (8) 1327-1333;
Yulin Ge
Robert I. Grossman
James S. Babb
Marcie L. Rabin
Lois J. Mannon

References
- ↵Biegon A, Eberling JL, Richardson BC, et al. Human corpus callosum in aging and Alzheimer’s disease: a magnetic resonance imaging study. Neurobiol Aging 1994;15:393–397
- ↵Giedd JN, Vaituzis AC, Hamburger SD, et al., Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: ages 4–18 years. J Comp Neuro 1996;366:223–230
- ↵Daigneault S, Braun CMJ, Whitaker HA. Early effects of normal aging on preservative and nonpreservative prefrontal measures. Dev Neuropsychol 1992;8:99–114
- ↵Convit A, de Leon MJ, Hoptman MJ, Tarshish C, De Santi S, Rusinek H. Age-related changes in brain: I. Magnetic resonance imaging measures of temporal lobe volumes in normal subjects. Psychiatr Q 1995;66:343–355
- ↵Luft AR, Skalej M, Schulz JB, et al. Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry. Cerebr Cortex 1999;9:712–721
- ↵Coffey CE, Wilkinson WE, Parashos IA, et al. Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology 1992;42:527–536
- ↵Miller AK, Alston RL, Corsellis JA. Variation with age in the volumes of grey and white matter in the cerebral hemispheres of man: measurements with an image analyzer. Neuropathol Appl Neurobiol 1980;6:119–132
- ↵Cowell PE, Turetsky BI, Gur RC, Grossman RI, Shtasel DL, Gur RE. Sex differences in aging of the human frontal and temporal lobes. J Neurosci 1994;14:4748–4755
- ↵Xu J, Kobayashi S, Yamaguchi S, Iijima K, Okada K, Yamashita K. Gender effects on age-related changes in brain structure. Am J Neuroradiol 2000;21:112–118
- ↵Jernigan TL, Press GA, Hesselink JR. Methods for measuring brain morphologic features on magnetic resonance images: validation and normal aging. Arch Neurol 1990;47:27–32
- Raz N, Gunning FM, Head D, et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 1997;7:268–282
- Pruessner JC, Collins DL, Pruessner M, Evans AC. Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood. J Neurosci 2001;21:194–200
- ↵Guttmann CR, Jolesz F, Kikinis R, Killiary RJ, Moss MB, Sandor T, Albert MS. White matter changes with normal aging. Neurology 1998;50:972–978
- ↵Meier-Ruge W, Ulrich J, Bruhlmann M, Meier E. Age-related white matter atrophy in the human brain. Ann N Y Acad Sci 1992;26:260–269
- ↵Double KL, Kalliday GM, Kril JJ, et al., Topography of brain atrophy during normal aging and Alzheimer’s disease. Neurobiol Aging 1996;17:513–521
- DeCarli CD, Murphy G, et al. Lack of age-related differences in temporal lobe volume of very healthy adults. AJNR Am J Neuroradiol 1994;15:689–696
- ↵Salat DH, Kaye JA, Janowsky JS. Prefrontal gray and white matter volumes in healthy aging and Alzheimer disease. Arch Neurol 1999;56:338–344
- ↵Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus. Neurobiol Aging 1995;16:591–606
- ↵Giedd JN, Snell JW, Lange N, et al. Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb Cortex 1996;6:551–560
- ↵Courchesne E, Chisum HJ, Townsend J, et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 2000;216:672–682
- ↵Udupa JK, Oduhner D, Samaraskera S, et al. 3DVIEWNIX: an open, transportable, multidimensional, multimodality, multiparametric imaging software system. Proc SPIE 1994;2164:58–73
- ↵Udupa JK, Wei L, Samarasekera S, Miki Y, van Buchem Grossman RI. Multiple sclerosis lesion quantification using fuzzy-connectedness principles. IEEE Trans Med Imaging 1997;16:598–609
- ↵Ge Y, Grossman RI, Udupa JK, Babb JS, Nyul LG, Kolson DL. Brain atrophy in relapsing-remitting multiple sclerosis: a fractional volumetric analysis of gray matter and white matter. Radiology 2001;220:606–610
- ↵Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipusky RB, Lim KO. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol 1994;51:874–887
- ↵Webb SJ, Monk CS, Nelson CA. Mechanisms of postnatal neurobiological development: implications for human development. Dev Neuropsychol 2001;19:147–171
- ↵Mueller EA, Moore MM, Kerr DC, et al. Brain volume preserved in healthy elderly through the eleventh decade. Neurology 1998;51:1555–1562
- ↵Haug H. Are neurons of the human cerebral cortex really lost during aging? A morphometric evaluation. In: Traber J, Gispen WH, eds. Senile Dementia of the Alzheimer Type Berlin,Germay: Springer-Verlag;1985 :150–163
- Terry RD, Deteresa R, Hansen LA. Neocortical cell counts in normal human adult aging. Ann Neurol 1987;21:530–539
- ↵Peters A, Morrison JH, Rosene DL, Hyman BT. Feature article: are neurons lost from the primate cerebral cortex during normal aging? Cereb Cortex 1998;8:295–300
- ↵Kitagaki H, Hirono N, Ishii K, Mori E. Corticobasal degeneration: evaluation of cortical atrophy by means of hemispheric surface display generated with MR images. Radiology 2000;216:31–38
- ↵Bartzokis G, Beckson M, Lu PH, Nuechterlein KH, Edwards N, Mintz J. Age-related changes in frontal and temporal lobe volumes in men: a magnetic resonance imaging study. Arch Gen Psychiatry 2001;58:461–465
- ↵Braffman BH, Zimmerman RA, Trojanowski JQ, Gonatas NK, Hickey WF, Schlaepfer WW. Brain MR: pathologic correlation with gross and histopathology, II: hyperintense foci in the elderly. Am J Neuroradiol 1988;9:629–636
- ↵Scheltens P, Barkhof F, Leyes D, Wolters EC, Ravid R, Kamphorst W. Histopathologic correlates of white matter changes on MRI in Alzheimer’s disease and normal aging. Neurology 1995;45:883–888
- ↵Virta A, Barnett A, Pierpaoli A. Visualizing and characterizing white matter fiber structure and architecture in the human pyramidal tract using diffusion tensor MRI. Magn Reson Imaging 1999;17:1121–1133
- ↵van Swieten JC, van Den Hout JHW, van Ketel BA, Hydra A, Wokke JHJ, van Gijn J. Periventricular lesions in the white matter on magnetic resonance imaing in the elderly. Brain 1991;114:761–774
- ↵Sze G, DeArmond S. Brant-Zawadski M, Davis RL, Norman D, Newton TH. Foci of MRI signal (pseudo lesions) anterior to the frontal horns: histologic correlations of a normal finding. Am J Neuroradiol 1986;7:381–387
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. Pathologic correlates of incidental MRI white matter signal hyperintensities. Neurology 1993;43:1683–1689
- ↵Awad IA, Johnson PC, Spetzler RF, Hodak JA. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly, II: postmortem pathological correlations. Stroke 1986;17:1090–1097
- ↵Fazekas F, Kleinert R, Offenbacher H, et al. The morphologic correlate of incidental white matter hyperintensities on MR images. Am J Neuroradiol 1991;12:915–921
- ↵Grafton ST, Sumi SM, Stimac GK, Alvord EC. Jr., Shaw CM, Nochilin D. Comparison of postmortem magnetic resonance imaging and neuropathologic findings in the cerebral white matter. Arch Neurol 1991;48:293–298
- ↵Hofman PA, Kemerink GJ, Jolles J, Wilmink JT. Quantitative analysis of magnetization transfer images of the brain: effect of closed head injury, age and sex on white matter. Magn Reson Med 1999;42:803–806
- ↵Narayana PA, Borthakur A. Effect of radio frequency inhomogeneity correction on the reproducibility of intra-cranial volumes using MR image data. Magn Reson Med 1995;33:396–400
- Passe TJ, Rajagopalan P, Tupler LA, Byrum CE, MacFall JR, Krishnan KR. Age and sex effects on brain morphology. Prog Neuropsychopharmacology Biol Psychiatry 1997;21:1231–1237
- Oguro H, Okada K, Yamaguchi S, Kobayashi S. Sex differences in morphology of the brain stem and cerebellum with normal ageing. Neuroradiology 1998;40:788–792
- ↵Murphy DG, Decarli C, Mclntosh AR, et al. Sex differences in human brain morphometry and metabolism: an in vivo quantitative magnetic resonance imaging and positron emission tomography study on the effect of aging. Arch Gen Psychiatry 1996;53:585–594
- ↵Schuff N, Ezekiel F, Gamst AC, et al. Region and tissue differences of metabolites in normally aged brain using multislice 1H magnetic resonance spectroscopic imaging. Magn Reson Med 2001;45:899–907
- ↵Autti T, Raininko R, Vanhanen SL, Kallio M, Santavuori P. MRI of the normal brain from early childhood to middle age, II: age dependence of signal intensity changes on T2-weighted images. Neuroradiology 1994;36:649–651
- ↵Leys D, Soetaert G, Petit H, Fauquette A, Pruvo JP, Steinling M. Periventricular and white matter magnetic resonance imaging hyperintensities do not differ between Alzheimer’s disease and normal aging. Arch of Neurol 1990;47:524–527
In this issue
Advertisement
Yulin Ge, Robert I. Grossman, James S. Babb, Marcie L. Rabin, Lois J. Mannon, Dennis L. Kolson
Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part I: Volumetric MR Imaging Analysis
American Journal of Neuroradiology Sep 2002, 23 (8) 1327-1333;
0 Responses
Jump to section
Related Articles
- No related articles found.
Cited By...
- Structure-function multilayer network integration and cognition in multiple sclerosis
- Meditation Experience is Associated with Increased Structural Integrity of the Pineal Gland and greater total Grey Matter maintenance
- Network Occlusion Sensitivity Analysis Identifies Regional Contributions to Brain Age Prediction
- Resilience and resistance to Alzheimers disease-associated neuropathological substrates in centenarians: an age-continuous perspective
- Age-related differences in GABA: Impact of analysis technique
- White matter brain age as a biomarker of cerebrovascular burden in the ageing brain
- Age- and sex-related differences in baboon (Papio anubis) gray matter covariation
- The Macromolecular MR Spectrum in Healthy Aging
- Multimodal multilayer network centrality relates to executive functioning
- Attentional bias to threat and gray mater volume morphology in high anxious individuals
- Cross-sectional volumes and trajectories of the human brain, gray matter, white matter and cerebrospinal fluid in 9,473 typically aging adults
- Functional connectivity within and between n-back modulated regions: An adult lifespan PPI investigation
- Blood Pressure Variation and Subclinical Brain Disease
- Aging and the Brain: A Quantitative Study of Clinical CT Images
- Lobule-specific dosage considerations for cerebellar transcranial direct current stimulation during healthy aging - a computational modeling study using age-specific MRI templates
- Brain-predicted age difference score is related to specific cognitive functions: A multi-site replication analysis
- eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data
- Assessing distinct patterns of cognitive aging using tissue-specific brain age prediction based on diffusion tensor imaging and brain morphometry
- Effects of Aging on Cortical Neural Dynamics and Local Sleep Homeostasis in Mice
- Accelerated aging of the putamen in patients with major depressive disorder
- Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
- Three-decade neurological and neurocognitive follow-up of HIV-1-infected patients on best-available antiretroviral therapy in Finland
- Frontotemporal Connections in Episodic Memory and Aging: A Diffusion MRI Tractography Study
- Normal Aging in the Basal Ganglia Evaluated by Eigenvalues of Diffusion Tensor Imaging
- Minute Effects of Sex on the Aging Brain: A Multisample Magnetic Resonance Imaging Study of Healthy Aging and Alzheimer's Disease
- Evolution of different MRI measures in patients with active relapsing-remitting multiple sclerosis over 2 and 5 years: a case-control study
- Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
- Proton MR Spectroscopy and MRI-Volumetry in Mild Traumatic Brain Injury
- Voxel-based detection of white matter abnormalities in mild Alzheimer disease
- Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI
- Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
- Frontal Lobe Volume, Function, and {beta}-Amyloid Pathology in a Canine Model of Aging
- Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.
More in this TOC Section
Similar Articles
Advertisement