Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR is seeking candidates for the AJNR Podcast Editor. Read the position description.

Research ArticleBRAIN

Brain Atrophy in Mild or Moderate Traumatic Brain Injury: A Longitudinal Quantitative Analysis

John D. MacKenzie, Faez Siddiqi, James S. Babb, Linda J. Bagley, Lois J. Mannon, Grant P. Sinson and Robert I. Grossman
American Journal of Neuroradiology October 2002, 23 (9) 1509-1515;
John D. MacKenzie
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Faez Siddiqi
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James S. Babb
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Linda J. Bagley
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lois J. Mannon
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grant P. Sinson
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert I. Grossman
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

Article Figures & Data

Figures

  • Tables
  • Fig 1.
    • Download figure
    • Open in new tab
    • Download powerpoint
    Fig 1.

    Visible atrophic changes after moderate TBI.

    A and B, Left frontal lobe contusion with local atrophy. The first (A) and second (B) MR images were obtained 390 days apart.

    C and D, Left parietal lesion and increased sulcal prominence. The first (C) and second (D) MR images were 118 days apart.

Tables

  • Figures
    • View popup
    TABLE 1:

    Single Time-Point Analysis

    MeasureAll Subjects (n = 24)Patients with TBI (n = 14)Control Subjects (n = 10)
    MeanMedianSDMeanMedianSDMeanMedianSD
    Age (y)35.635.310.236.133.412.134.936.97.1
    %VBP*86.387.03.886.287.24.386.486.53.2
    CSF (cm3)199.5199.062.7199.5195.271.7199.6200.351.1
    VBP (cm3)1248.01229.6127.51234.41207.1140.21267.01282.3111.7
    • * %VBP = VBP/(VBP + CSF volume).

    • View popup
    TABLE 2:

    Longitudinal Analysis

    MeasureFirst ExaminationSecond ExaminationChange
    MeanSDMeanSDMeanSD
    Control subjects (n = 4)
     Age (y)35.16.5NANANANA
     %VBP*87.03.885.52.5−1.491.7
     CSF (cm3)187.951.4208.738.720.926.4
     VBP (cm3)1270.4151.51237.2131.0−33.323.8
    Patients with TBI (n = 7)
     Age (y)36.715.1NANANANA
     %VBP*85.14.780.95.6−4.16†1.68
     CSF (cm3)223.676.3270.3105.746.734.8
     VBP (cm3)1279.4159.11122.1110.3−157.3237.6
    • Note.—NA indicates not applicable.

    • * %VBP = VBP/(VBP + CSF volume).

    • † P = .022 shows significant difference between control and patient groups.

PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 23 (9)
American Journal of Neuroradiology
Vol. 23, Issue 9
1 Oct 2002
  • Table of Contents
  • Index by author
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Brain Atrophy in Mild or Moderate Traumatic Brain Injury: A Longitudinal Quantitative Analysis
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
John D. MacKenzie, Faez Siddiqi, James S. Babb, Linda J. Bagley, Lois J. Mannon, Grant P. Sinson, Robert I. Grossman
Brain Atrophy in Mild or Moderate Traumatic Brain Injury: A Longitudinal Quantitative Analysis
American Journal of Neuroradiology Oct 2002, 23 (9) 1509-1515;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Brain Atrophy in Mild or Moderate Traumatic Brain Injury: A Longitudinal Quantitative Analysis
John D. MacKenzie, Faez Siddiqi, James S. Babb, Linda J. Bagley, Lois J. Mannon, Grant P. Sinson, Robert I. Grossman
American Journal of Neuroradiology Oct 2002, 23 (9) 1509-1515;
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Conclusion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Prospective cohort study of long-term neurological outcomes in retired elite athletes: the Advanced BiomaRker, Advanced Imaging and Neurocognitive (BRAIN) Health Study protocol
  • Apolipoprotein E genotype modulates longitudinal atrophy at the temporal lobe after mild traumatic brain injury
  • Changes in brain structure and function in a multisport cohort of retired female and male athletes, many years after suffering a concussion. The ICHIRF-BRAIN Study
  • Association between mild traumatic brain injury, brain structure, and mental health outcomes in the Adolescent Brain Cognitive Development Study
  • The relationship between brain atrophy and cognitive-behavioral symptoms in retired Canadian football players with multiple concussions
  • Near-Term Decrease in Brain Volume following Mild Traumatic Injury Is Detectible in the Context of Preinjury Volumetric Stability: Neurobiologic Insights from Analysis of Historical Imaging Examinations
  • A longitudinal MRI study of traumatic axonal injury in patients with moderate and severe traumatic brain injury
  • Proton MR Spectroscopy and MRI-Volumetry in Mild Traumatic Brain Injury
  • Hippocampal volume, brain atrophy, and APOE genotype after traumatic brain injury.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Usefulness of Quantitative Susceptibility Mapping for the Diagnosis of Parkinson Disease
  • White Matter Alterations in the Brains of Patients with Active, Remitted, and Cured Cushing Syndrome: A DTI Study
  • Qualitative and Quantitative Analysis of MR Imaging Findings in Patients with Middle Cerebral Artery Stroke Implanted with Mesenchymal Stem Cells
Show more BRAIN

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • AJNR Awards
  • ASNR Foundation Special Collection
  • Most Impactful AJNR Articles
  • Photon-Counting CT
  • Spinal CSF Leak Articles (Jan 2020-June 2024)

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire