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Research ArticlePEDIATRICS

MR Imaging Quantification of Cerebellar Growth Following Hypoxic-Ischemic Injury to the Neonatal Brain

Elisabeth Le Strange, Nadeem Saeed, Frances M. Cowan, A. David Edwards and Mary A. Rutherford
American Journal of Neuroradiology March 2004, 25 (3) 463-468;
Elisabeth Le Strange
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Nadeem Saeed
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Frances M. Cowan
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A. David Edwards
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Mary A. Rutherford
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  • Fig 1.
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    Fig 1.

    T1-weighted MR images (860/20).

    A, Day 5 image shows focal infarction. There is a loss of gray matter–white matter differentiation in the posterior lobe on the left. This is consistent with perinatal infarction within the territory of the left middle cerebral artery.

    B, Day 12 image shows basal ganglia and thalamic lesions. There are persistent, abnormal high-signal-intensity regions in the posterior lentiform nuclei and lateral thalami (arrows). The intervening posterior limb of the internal capsule shows reduced high signal intensity from myelin.

  • Fig 2.
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    Fig 2.

    Total cerebellar volume versus age in all infants, by group (n = 20).

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    Fig 3.

    Cerebellar hemispheres in infants with cerebral infarcts. Volume ipsilateral to the infarct versus volume contralateral to the infarct (n = 11). The line is the line of equality.

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    Fig 4.

    Cerebellar hemispheres in all infants. Volume of the right hemisphere versus volume of the left hemisphere (n = 20). The line is the line of equality.

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    Fig 5.

    Cross-sectional area of the vermis versus age (n = 20).

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    Fig 6.

    Cross-sectional area of the vermis versus total cerebellar volume (n = 23).

Tables

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  • Clinical details and timing of studies

    Patient no.GestationFetal Distress*Delivery†Apgar ScoresBirthweight, kgMR Imaging Findings‡Age at StudiesOutcomeHead Circumference at ≥12 mo
    141Ctg/mslNvd5,83.75Transient bg2 d, 3 d, 4 mNormal1st
    240CtgEmcd1,72.46Normal3 m, 6 mNormal25th
    340CtgEmcd1,53.12Transient bg6 d, 1 m, 3 m, 7 mNormal50th
    441NilNvd7,93.56Infarct, left1 m, 2 mNormal25th
    539NilNvd3,53.35Infarct, left1 m, 3 m, 5 mModerate<0.4th
    640NilNvd9,102.84Infarct, left1 m, 3 m, 8 mNormal75th
    740CtgEmcd2,73.68Infarct, left2 d, 3 d, 9 dNormal9–25th
    841Ctg/mslEmcd5,92.9Infarct, right2 d, 9 d, 1 m, 3 m, 6 mNormal2–9th
    941MslEmcs4,93.12Infarct, right3 m, 5 m, 9 mModerate25th
    1041Ctg/mslForceps5,74.25Infarct, left6 d, 1.5 m, 3 m, 6 mNormal25th
    1142MslVentouse6,83.1Infarct, left6 d, 1 m, 3 mNormal25th
    1239NilNvd7,103.59Infarct, left6 m, 21 mModerate91st
    1339NilNvd5,73.34Infarct, left7 d, 1 m, 3 m, 8 mNormal<25th
    1441Ctg/mslEmcd2,83.22Infarct, left9 d, 16 d, 1.5 m, 3 m, 6 mModerate20th
    1542CtgEmcd0NASevere bg1.3 m, 3.5 m, 12 mSevere<3rd
    1641CtgForceps1,42.8Severe bg, wm1.5 m, 6 mSevere<0.4th
    1742Ctg/mslForceps0,04Severe bg11 m, 14 mSevere<0.4th
    2839Ctg/mslEmcd0,03.08Severe bg11 d, 2 m, 6.5 m, 12 mSevere<0.4th
    1940CtgNvd0,33.13Moderate bg14 d, 4.5 m, 11.5 mSevere45th
    2040CtgNvd5,73.98Severe bg6 m, 13.5 mSevere<0.4th
    • * Ctg indicates cardiotocograph; msl, meconium-stained liquor.

    • † Emcd indicates emergency cesarean delivery; nvd, normal vaginal delivery.

    • ‡ bg indicates basal ganglia lesions; wm, white matter.

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American Journal of Neuroradiology: 25 (3)
American Journal of Neuroradiology
Vol. 25, Issue 3
1 Mar 2004
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Cite this article
Elisabeth Le Strange, Nadeem Saeed, Frances M. Cowan, A. David Edwards, Mary A. Rutherford
MR Imaging Quantification of Cerebellar Growth Following Hypoxic-Ischemic Injury to the Neonatal Brain
American Journal of Neuroradiology Mar 2004, 25 (3) 463-468;

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MR Imaging Quantification of Cerebellar Growth Following Hypoxic-Ischemic Injury to the Neonatal Brain
Elisabeth Le Strange, Nadeem Saeed, Frances M. Cowan, A. David Edwards, Mary A. Rutherford
American Journal of Neuroradiology Mar 2004, 25 (3) 463-468;
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  • Evaluation of Posterior Fossa Biometric Measurements on Fetal MRI in the Evaluation of Dandy-Walker Continuum
  • Uneven distribution of Purkinje cell injury in the cerebellar vermis of term neonates with hypoxic-ischemic encephalopathy
  • Injury to the Cerebellum in Term Asphyxiated Newborns Treated with Hypothermia
  • Predicting motor outcome and death in term hypoxic-ischemic encephalopathy
  • Does perinatal asphyxia impair cognitive function without cerebral palsy?
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