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Brain Apparent Diffusion Coefficient Decrease During Correction of Severe Hypernatremic Dehydration

Andrea Righini, Luca Ramenghi, Salvatore Zirpoli, Fabio Mosca and Fabio Triulzi
American Journal of Neuroradiology August 2005, 26 (7) 1690-1694;
Andrea Righini
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Luca Ramenghi
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Salvatore Zirpoli
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Fabio Mosca
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Fabio Triulzi
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    Fig 1.

    Time course of sodium and chlorum serum concentrations during the neonatal intensive care unit stay. I MRI indicates the first imaging study.

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    Fig 2.

    Two T2-weighted fast spin-echo (A, D), diffusion-weighted (B, E), and trace apparent diffusion coefficient–calculated (C) f-axial sections from the first (time course, 0 hours) MR imaging study are reported. Ventricular and cortical cerebrospinal fluid spaces are clearly reduced. The black arrowhead shows clear swelling of the corpus callosum (especially if compared with Fig 4). The white arrow shows the thickened posterior limb of the internal capsula, and the black arrow shows increased diffusion-weighted signal intensity within the myelinated white matter at the same location. Moderate T2-weighted signal intensity increase is visible within the posterior thalamus bilaterally. The white arrowhead indicates the swollen cortical rim. Circular regions of interest for frontal and occipital unmyelinated white matter are shown for one hemisphere on T2-weighted section (D). Regions of interest for basal ganglia, frontal and occipital unmyelinated white matter, and myelinated white matter of the internal capsula are depicted on apparent diffusion coefficient maps (C and F). These regions of interest were transferred from T2 b = 0 corresponding sections. Cortical gray matter regions of interest could not be traced because of partial volume effect.

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    Fig 3.

    A, Graph shows plot of the average apparent diffusion coefficient value (with standard deviation of unmyelinated white matter [UMWM]), myelinated white matter (MWM), and basal ganglia (BG) regions of interest in the first (I MRI) and second (II MRI) MR imaging study. B, Graph shows plot of the average value (with standard deviation) of the ratio between T2-weighted signal intensity of frontal-occipital unmyelinated white matter and of cerebrospinal fluid in the first and second MR imaging studies and in normal controls (n = 5).

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    Fig 4.

    Two T2-weighted (A, D), diffusion-weighted (B, E), and trace apparent diffusion coefficient–calculated (C) f-axial sections from the second (at 200 hours) MR imaging study, obtained at a location similar to that of Fig 2, are reported. Cerebrospinal fluid spaces and brain parenchyma signal intensity are normal. The cortical rim and corpus callosum are no longer swollen. The regions of interest are the same ones as depicted in Fig 2.

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American Journal of Neuroradiology: 26 (7)
American Journal of Neuroradiology
Vol. 26, Issue 7
1 Aug 2005
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Andrea Righini, Luca Ramenghi, Salvatore Zirpoli, Fabio Mosca, Fabio Triulzi
Brain Apparent Diffusion Coefficient Decrease During Correction of Severe Hypernatremic Dehydration
American Journal of Neuroradiology Aug 2005, 26 (7) 1690-1694;

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Brain Apparent Diffusion Coefficient Decrease During Correction of Severe Hypernatremic Dehydration
Andrea Righini, Luca Ramenghi, Salvatore Zirpoli, Fabio Mosca, Fabio Triulzi
American Journal of Neuroradiology Aug 2005, 26 (7) 1690-1694;
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