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Research ArticleBRAIN

The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics?

G.A. Bateman
American Journal of Neuroradiology January 2008, 29 (1) 198-203; DOI: https://doi.org/10.3174/ajnr.A0739
G.A. Bateman
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    Fig 1.

    A sagittal T1-weighted image of a patient with NPH, showing the flow quantification section positions: the arterial section (A), the aqueduct section (B), and the venous section (C).

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    Table 1:

    Blood flow

    Age (y)Cerebral Inflow (mL/min)SSS Outflow (mL/min)ST Outflow (mL/min)SSS Outflow as a % of Inflow (%)ST Outflow as a % of Inflow (%)
    Healthy elderly, n = 12 (SD)70 (5)710 (110)310 (65)90 (30)44 (9)13 (4)
    NPH, n = 20 (SD)71 (11)800 (90)280 (70)100 (20)35 (10)12 (3)
    P value.34.02*.41.52.04*.62
    • Note:—SSS, indicates superior sagittal sinus; ST, straight sinus.

    • * ttest P value < .05.

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    Table 2:

    Pulsation and compliance

    Age (y)AVD (ms)Arterial Pulse (μL)Aqueduct Pulse (μL)
    Healthy elderly, n = 12 (SD)70 (5)110 (50)1330 (380)48 (29)
    NPH, n = 20 (SD)71 (11)52 (22)1460 (650)140 (130)
    P value.34.0001*.5.02*
    • * t test P value < .05.

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American Journal of Neuroradiology: 29 (1)
American Journal of Neuroradiology
Vol. 29, Issue 1
January 2008
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G.A. Bateman
The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics?
American Journal of Neuroradiology Jan 2008, 29 (1) 198-203; DOI: 10.3174/ajnr.A0739

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The Pathophysiology of Idiopathic Normal Pressure Hydrocephalus: Cerebral Ischemia or Altered Venous Hemodynamics?
G.A. Bateman
American Journal of Neuroradiology Jan 2008, 29 (1) 198-203; DOI: 10.3174/ajnr.A0739
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    NMR in Biomedicine 2011 24 4
  • A Phase-Contrast MRI Study of Physiologic Cerebral Venous Flow
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  • Pathogenesis and pathophysiology of idiopathic normal pressure hydrocephalus
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    CNS Neuroscience & Therapeutics 2020 26 12
  • Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats
    Lucy A Murtha, Qing Yang, Mark W Parsons, Christopher R Levi, Daniel J Beard, Neil J Spratt, Damian D McLeod
    Fluids and Barriers of the CNS 2014 11 1
  • Venous hemodynamics in neurological disorders: an analytical review with hydrodynamic analysis
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    BMC Medicine 2013 11 1
  • Phase contrast MRI quantification of pulsatile volumes of brain arteries, veins, and cerebrospinal fluids compartments: Repeatability and physiological interactions
    Anders Wåhlin, Khalid Ambarki, Jón Hauksson, Richard Birgander, Jan Malm, Anders Eklund
    Journal of Magnetic Resonance Imaging 2012 35 5
  • Normal-pressure hydrocephalus: A critical review
    Louise Makarem Oliveira, Ricardo Nitrini, Gustavo C. Román
    Dementia & Neuropsychologia 2019 13 2

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