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Research ArticleInterventionalT
Open Access

A Novel Method of Thrombus Preparation for Use in a Swine Model for Evaluation of Thrombectomy Devices

I. Kan, I. Yuki, Y. Murayama, F.A. Viñuela, R.H. Kim, H.V. Vinters and F. Viñuela
American Journal of Neuroradiology October 2010, 31 (9) 1741-1743; DOI: https://doi.org/10.3174/ajnr.A1991
I. Kan
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I. Yuki
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Y. Murayama
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F.A. Viñuela
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R.H. Kim
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H.V. Vinters
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F. Viñuela
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    Fig 1.

    Photographs showing a manual elongation test of a thrombin-induced thrombus (A and B) and a new experimental thrombus (C and D). Note that most of the thrombin-induced thrombus was torn before it attained a doubling of its length (A and B), whereas the new experimental thrombi were more elastic and solid and most of them tolerated stretching to 3 times the length of the original size (C and D).

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    Fig 2.

    Photomicrographs of 3 different types of thrombus. A, Thrombin-induced thrombus was replete with erythrocytes and lacked a layered structure. B, Most thromboemboli recovered from patients with stroke showed a layered structure, including fibrin-rich (F) and erythrocyte-rich (E) layers. C, New experimental thrombus presented a layered pattern similar to that observed in the thromboemboli recovered from patients with stroke (B). C indicates a cellular component; E, an erythrocyte-rich component; F, a fibrin-rich component (hematoxylin-eosin, original magnification ×40).

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    Fig 3.

    Representative angiograms after deployment of the new experimental thrombus (lateral view, right common carotid artery injection). A, Complete occlusion of an internal maxillary artery was confirmed with a digital subtraction image. B, Nonsubtracted image showed sufficient radiopacity of the injected thrombus.

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American Journal of Neuroradiology: 31 (9)
American Journal of Neuroradiology
Vol. 31, Issue 9
1 Oct 2010
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I. Kan, I. Yuki, Y. Murayama, F.A. Viñuela, R.H. Kim, H.V. Vinters, F. Viñuela
A Novel Method of Thrombus Preparation for Use in a Swine Model for Evaluation of Thrombectomy Devices
American Journal of Neuroradiology Oct 2010, 31 (9) 1741-1743; DOI: 10.3174/ajnr.A1991

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A Novel Method of Thrombus Preparation for Use in a Swine Model for Evaluation of Thrombectomy Devices
I. Kan, I. Yuki, Y. Murayama, F.A. Viñuela, R.H. Kim, H.V. Vinters, F. Viñuela
American Journal of Neuroradiology Oct 2010, 31 (9) 1741-1743; DOI: 10.3174/ajnr.A1991
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  • Impact of Target Artery Size on the Performance of Aspiration Thrombectomy: Insights from a Swine Model with Real-Time Visualization
  • Novel methodology to replicate clot analogs with diverse composition in acute ischemic stroke
  • Histopathologic Evaluation of Arterial Wall Response to 5 Neurovascular Mechanical Thrombectomy Devices in a Swine Model
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  • The hyperdense vessel sign on CT predicts successful recanalization with the Merci device in acute ischemic stroke
  • Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model
  • A Comparison of 2 Stroke Devices: The New Aperio Clot-Removal Device and the Solitaire AB/FR
  • The Impact of Thromboemboli Histology on the Performance of a Mechanical Thrombectomy Device
  • Mechanical Characterization of Thromboemboli in Acute Ischemic Stroke and Laboratory Embolus Analogs
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Mechanical Characterization of Thromboemboli in Acute Ischemic Stroke and Laboratory Embolus Analogs
    J.Y. Chueh, A.K. Wakhloo, G.H. Hendricks, C.F. Silva, J.P. Weaver, M.J. Gounis
    American Journal of Neuroradiology 2011 32 7
  • The Impact of Thromboemboli Histology on the Performance of a Mechanical Thrombectomy Device
    I. Yuki, I. Kan, H.V. Vinters, R.H. Kim, A. Golshan, F.A. Vinuela, J.W. Sayre, Y. Murayama, F. Vinuela
    American Journal of Neuroradiology 2012 33 4
  • Novel methodology to replicate clot analogs with diverse composition in acute ischemic stroke
    Sharon Duffy, Michael Farrell, Kevin McArdle, John Thornton, David Vale, Eleanor Rainsford, Liam Morris, David S Liebeskind, Eugene MacCarthy, Michael Gilvarry
    Journal of NeuroInterventional Surgery 2017 9 5
  • Histopathologic Evaluation of Arterial Wall Response to 5 Neurovascular Mechanical Thrombectomy Devices in a Swine Model
    B. Gory, D. Bresson, I. Kessler, M.L. Perrin, A. Guillaudeau, K. Durand, S. Ponsonnard, C. Couquet, C. Yardin, C. Mounayer
    American Journal of Neuroradiology 2013 34 11
  • The hyperdense vessel sign on CT predicts successful recanalization with the Merci device in acute ischemic stroke
    Michael T Froehler, Satoshi Tateshima, Gary Duckwiler, Reza Jahan, Nestor Gonzalez, Fernando Vinuela, David Liebeskind, Jeffrey L Saver, J Pablo Villablanca
    Journal of NeuroInterventional Surgery 2013 5 4
  • The Mechanical Characterisation of Bovine Embolus Analogues Under Various Loading Conditions
    F. Malone, E. McCarthy, P. Delassus, P. Fahy, J. Kennedy, A. J. Fagan, L. Morris
    Cardiovascular Engineering and Technology 2018 9 3
  • A Comparison of 2 Stroke Devices: The New Aperio Clot-Removal Device and the Solitaire AB/FR
    C. Roth, D. Junk, P. Papanagiotou, A. Keuler, H. Körner, M. Schumacher, W. Reith
    American Journal of Neuroradiology 2012 33 7
  • A Swine Model to Analyze Arterial Structural Changes Induced by Mechanical Thrombectomy
    I. Yuki, I. Kan, A. Golshan, J. Sohn, Y. Murayama, H.V. Vinters, F. Viñuela
    American Journal of Neuroradiology 2013 34 8
  • Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model
    Motoaki Fujimoto, Noriko Salamon, Fernando Mayor, Ichiro Yuki, Koichiro Takemoto, Harry V. Vinters, Fernando Viñuela
    Stroke 2013 44 5
  • Artificial Stroke Clots: How Wide is the Gap to the Real World?
    Maria Berndt, Sascha Prothmann, Christian Maegerlein, Paul Oberdieck, Claus Zimmer, Barbara Hegge, Jaroslav Pelisek, Lucas Schirmer, Holger Poppert, Tobias Boeckh-Behrens
    World Neurosurgery 2018 110

More in this TOC Section

  • SAVE vs. Solumbra Techniques for Thrombectomy
  • Contrast-Induced Encephalopathy after NeuroIR
  • CT Perfusion&Reperfusion in Acute Ischemic Stroke
Show more Interventional

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