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Research ArticleBrain

Voxelwise Analysis of Diffusion Tensor Imaging and Structural MR Imaging in Patients with the m.3243A>G Mutation in Mitochondrial DNA

S.M. Virtanen, M.M. Lindroos, K. Majamaa, P. Nuutila, R.J. Borra and R. Parkkola
American Journal of Neuroradiology March 2011, 32 (3) 522-526; DOI: https://doi.org/10.3174/ajnr.A2309
S.M. Virtanen
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M.M. Lindroos
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K. Majamaa
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P. Nuutila
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R.J. Borra
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R. Parkkola
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    Fig 1.

    Results of the TBSS analysis of the FA data overlaid on a standard MNI152 image. Areas of reduced FA in patients with m.3243A>G are seen bilaterally in occipital parts of the inferior longitudinal fasciculi, thalami, external capsules; the posterior limbs of internal capsules, mesencephalon, pons, superior, middle and inferior cerebellar peduncles; cerebellar white matter and medulla oblongata; on the left side in the tracts of forceps major; on the temporal part of the inferior longitudinal fasciculus; and on the dorsal cingulum. The horizontal bar shows the color scale, and the values under the bar are 1-P. The image is thresholded at P = .05, so that only statistically significant voxels are shown.

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    Fig 2.

    Results of the FSL-VBM analysis overlaid on a standard MNI152 image. Areas of reduced gray matter volume in patients with m.3243A>G are seen bilaterally in the occipital pole regions, intracalcarine cortex regions and cerebellar gray matter, and on the left side in the superior part of the occipital cortex. The horizontal bar shows the color scale and the values under the bar are 1-P. The image is thresholded at P = .05, so that only statistically significant voxels are shown.

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American Journal of Neuroradiology: 32 (3)
American Journal of Neuroradiology
Vol. 32, Issue 3
1 Mar 2011
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Cite this article
S.M. Virtanen, M.M. Lindroos, K. Majamaa, P. Nuutila, R.J. Borra, R. Parkkola
Voxelwise Analysis of Diffusion Tensor Imaging and Structural MR Imaging in Patients with the m.3243A>G Mutation in Mitochondrial DNA
American Journal of Neuroradiology Mar 2011, 32 (3) 522-526; DOI: 10.3174/ajnr.A2309

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Voxelwise Analysis of Diffusion Tensor Imaging and Structural MR Imaging in Patients with the m.3243A>G Mutation in Mitochondrial DNA
S.M. Virtanen, M.M. Lindroos, K. Majamaa, P. Nuutila, R.J. Borra, R. Parkkola
American Journal of Neuroradiology Mar 2011, 32 (3) 522-526; DOI: 10.3174/ajnr.A2309
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