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Should Patients with Autosomal Dominant Polycystic Kidney Disease Be Screened for Cerebral Aneurysms?

M.N. Rozenfeld, S.A. Ansari, A. Shaibani, E.J. Russell, P. Mohan and M.C. Hurley
American Journal of Neuroradiology January 2014, 35 (1) 3-9; DOI: https://doi.org/10.3174/ajnr.A3437
M.N. Rozenfeld
aFrom the Department of Radiology (M.N.R., P.M.), St. Francis Hospital, Evanston, Illinois
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S.A. Ansari
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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A. Shaibani
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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E.J. Russell
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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P. Mohan
aFrom the Department of Radiology (M.N.R., P.M.), St. Francis Hospital, Evanston, Illinois
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M.C. Hurley
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois.
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    Fig 1.

    Specific to IA, the preclinical phase between formation and symptom development/rupture can be quite variable, and the clinical phase between symptom development and SAH/death can be quite short or nonexistent. Lead time is dependent on screening frequency. DPCP indicates detectable preclinical phase. Adapted from Morrison65 by permission of Oxford University Press, USA.

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    Table 1:

    Aneurysm characteristics in patients with ADPCKD versus the general population

    CharacteristicsGeneral PopulationADPCKD
    Male/female distribution71%–76% female46%–58% female
    Aneurysm location80%–90% anterior circulation90%–100% anterior circulation
    Multiple aneurysms35%18%–31%
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    Table 2:

    Five-year cumulative rupture rates from the ISUIA trial for patients without a history of SAH

    Artery<7 mm7–12 mm13–24 mm≥25 mm
    Cavernous carotid0%0%3%6.4%
    ACA/MCA/ICA0%2.6%14.5%40%
    PCA, PcomA, vertebrobasilar2.5%14.5%18.4%50%
    • Note:—PCA indicates posterior cerebral artery; PcomA, posterior communicating artery; ACA, anterior cerebral artery.

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American Journal of Neuroradiology: 35 (1)
American Journal of Neuroradiology
Vol. 35, Issue 1
1 Jan 2014
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M.N. Rozenfeld, S.A. Ansari, A. Shaibani, E.J. Russell, P. Mohan, M.C. Hurley
Should Patients with Autosomal Dominant Polycystic Kidney Disease Be Screened for Cerebral Aneurysms?
American Journal of Neuroradiology Jan 2014, 35 (1) 3-9; DOI: 10.3174/ajnr.A3437

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Should Patients with Autosomal Dominant Polycystic Kidney Disease Be Screened for Cerebral Aneurysms?
M.N. Rozenfeld, S.A. Ansari, A. Shaibani, E.J. Russell, P. Mohan, M.C. Hurley
American Journal of Neuroradiology Jan 2014, 35 (1) 3-9; DOI: 10.3174/ajnr.A3437
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  • KHA‐CARI guideline recommendations for the diagnosis and management of autosomal dominant polycystic kidney disease
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