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Research ArticleInterventional

Coiling of Large and Giant Aneurysms: Complications and Long-Term Results of 334 Cases

N. Chalouhi, S. Tjoumakaris, L.F. Gonzalez, A.S. Dumont, R.M. Starke, D. Hasan, C. Wu, S. Singhal, L.A. Moukarzel, R. Rosenwasser and P. Jabbour
American Journal of Neuroradiology March 2014, 35 (3) 546-552; DOI: https://doi.org/10.3174/ajnr.A3696
N. Chalouhi
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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S. Tjoumakaris
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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L.F. Gonzalez
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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A.S. Dumont
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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R.M. Starke
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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D. Hasan
bDepartment of Neurosurgery (D.H.), University of Iowa, Iowa City, Iowa.
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C. Wu
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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S. Singhal
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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L.A. Moukarzel
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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R. Rosenwasser
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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P. Jabbour
aFrom the Department of Neurosurgery (N.C., S.T., L.F.G., A.S.D., R.M.S., C.W., S.S., L.A.M., R.R., P.J.), Thomas Jefferson University and Jefferson Hospital for Neuroscience, Philadelphia, Pennsylvania
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Article Figures & Data

Tables

    • View popup
    Table 1:

    Location of treated aneurysms and respective complication and recurrence rates

    LocationNo. of Aneurysms (%)Complications (%)Recurrence (%)Retreatment (%)
    Paraclinoid63 (18.9)9 (14.3)26/53 (49)22/53 (41.5)
    Basilar artery53 (15.9)4 (7.5)16/43 (37.2)15/43 (34.9)
    Posterior communicating artery48 (14.4)6 (12.5)11/33 (33.3)10/33 (30.3)
    Carotid ophthalmic47 (14.1)3 (6.4)12/39 (30.8)10/39 (25.6)
    Anterior communicating artery34 (10.2)5 (14.7)6/25 (24)5/25 (20)
    Carotid cavernous27 (8.0)4 (14.8)9/21 (42.9)6/21 (28.6)
    Middle cerebral artery25 (7.5)2 (8)8/16 (50)5/16 (31.3)
    Carotid terminus17 (5.1)05/11 (45.5)4/11 (36.4)
    Vertebral artery13 (3.9)1 (7.7)5/12 (41.7)5/12 (41.7)
    Anterior cerebral artery6 (1.8)04/6 (66.7)4/6 (66.7)
    Posterior cerebral artery1 (0.3)00/10/1
    Total3343410285
    • View popup
    Table 2:

    Complications and angiographic outcomes per aneurysm size

    10–14 mm15–24 mm≥25 mm
    Complications22/216 (10.2%)9/86 (10.4%)3/32 (9.4%)
    Recurrence62/177 (35%)29/62 (46.8%)11/21 (52%)
    Retreatment52/177 (29.3%)23/62 (37.1%)10/21 (47.6%)
    • View popup
    Table 3:

    Predictors of recurrence and retreatment

    Odds Ratio95% CIP Value
    Procedural complications
        Ruptured aneurysms2.41.1–4.3.04a
        Aneurysm location2.11.1–3.9.02a
        Anterior circulation aneurysms2.00.9–5.0.09
    Recurrence
        Aneurysm size1.071.02–1.14.006a
        Follow-up time1.041.02–1.06<.001a
        Unassisted coiling and balloon remodeling21.1–3.3.02a
        Aneurysm location1.91.1–3.4.02a
    Retreatment
        Aneurysm size1.081.02–1.14.003a
        Follow-up time1.021.02–1.06.002a
        Unassisted coiling and balloon remodeling2.51.1–3.3.005a
        Aneurysm location2.021.1–3.4.02a
    New or recurrent hemorrhage
        Aneurysm size1.11.0–1.2.04a
        Follow-up time1.031.0–1.1.05a
        Aneurysm location2.51.5–7.01a
        Clinical outcome
        Aneurysm size0.890.82–0.97.01a
        Hunt and Hess grades0.360.24–0.55<.001a
        New or recurrent hemorrhage0.040.005–0.28.002a
    • ↵a Statistically significant values. Factors tested as predictors of complications: age, sex, embolization, initial aneurysm occlusion, and date of treatment. Factors tested as predictors of recurrence, retreatment, and new or recurrent hemorrhage: age, sex, aneurysm size, location, ruptured aneurysm status, Hunt and Hess grades, type of embolization, initial aneurysm occlusion, date of treatment, procedural complications, GOS at discharge, and follow-up time. Factors tested as predictors of clinical outcome: age, sex, aneurysm size, location, ruptured aneurysm status, Hunt and Hess grades, type of embolization, initial aneurysm occlusion, date of treatment, procedural complications, GOS at discharge, follow-up time, recurrence, retreatment, and new or recurrent hemorrhage.

    • View popup
    Table 4:

    Clinical outcome of treated patients

    GOSDischarge (%)Follow-Up (%)
    I, Death17 (5.3)7 (2.7)
    II, Vegetative state1 (0.3)1 (0.4)
    III, Severe disability18 (5.6)12 (4.7)
    IV, Moderate disability21 (6.5)17 (6.6)
    V, Mild/no disability265 (82.3)219 (85.6)
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American Journal of Neuroradiology: 35 (3)
American Journal of Neuroradiology
Vol. 35, Issue 3
1 Mar 2014
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Cite this article
N. Chalouhi, S. Tjoumakaris, L.F. Gonzalez, A.S. Dumont, R.M. Starke, D. Hasan, C. Wu, S. Singhal, L.A. Moukarzel, R. Rosenwasser, P. Jabbour
Coiling of Large and Giant Aneurysms: Complications and Long-Term Results of 334 Cases
American Journal of Neuroradiology Mar 2014, 35 (3) 546-552; DOI: 10.3174/ajnr.A3696

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Coiling of Large and Giant Aneurysms: Complications and Long-Term Results of 334 Cases
N. Chalouhi, S. Tjoumakaris, L.F. Gonzalez, A.S. Dumont, R.M. Starke, D. Hasan, C. Wu, S. Singhal, L.A. Moukarzel, R. Rosenwasser, P. Jabbour
American Journal of Neuroradiology Mar 2014, 35 (3) 546-552; DOI: 10.3174/ajnr.A3696
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