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Research ArticleAdult Brain

Residual Thromboembolic Material in Cerebral Arteries after Endovascular Stroke Therapy Can Be Identified by Dual-Energy CT

A.E. Grams, M. Knoflach, R. Rehwald, J. Willeit, M. Sojer, E.R. Gizewski and B. Glodny
American Journal of Neuroradiology August 2015, 36 (8) 1413-1418; DOI: https://doi.org/10.3174/ajnr.A4350
A.E. Grams
aFrom the Departments of Neuroradiology (A.E.G., E.R.G.)
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M. Knoflach
bNeurology (M.K., J.W., M.S.)
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R. Rehwald
cRadiology (R.R., B.G.), Medical University of Innsbruck, Innsbruck, Austria.
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J. Willeit
bNeurology (M.K., J.W., M.S.)
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M. Sojer
bNeurology (M.K., J.W., M.S.)
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E.R. Gizewski
aFrom the Departments of Neuroradiology (A.E.G., E.R.G.)
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B. Glodny
cRadiology (R.R., B.G.), Medical University of Innsbruck, Innsbruck, Austria.
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  • Fig 1.
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    Fig 1.

    Residual clot (arrow) in the left P2 segment on conventional angiography (A) and in the different dual-energy series: weighted dual-energy (B), virtual noncontrast (C), and iodine map (D). The arrows indicate the hyperattenuated residual clots in the DEw and the VNC series. No clot is visible in the IM series. Note demonstration of ROI measurements in the residual clots after magnification in the left lower image sections.

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    Fig 2.

    Mean values with upper/lower 95% confidence intervals and SDs of Hounsfield attenuation measured in clotted (A) and perfused (B) vessels in the weighted dual-energy and virtual noncontrast series and as a comparison of clotted and perfused vessels in the VNC series (C).

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    Table 1:

    Relevant information about the included patients

    No.SexAge (yr)ClotIntravenous ThrombolysisResidual ClotIntra-Arterial ThrombolysisHematocrit (l/l)
    1Female79BAYesRight P1Yes0.276
    2Male79BANoLeft P2Yes0.346
    3Male50Right MCAYesM2Yes0.441
    4Female73Left MCANoM2Yes0.401
    5Female58Right MCANoM3No0.429
    6Male63Left MCAYesM3Yes0.438
    7Female77Right MCAYesM2Yes0.419
    8Female51Right MCAYesM3Yes0.413
    9Female62Left MCANoM3Yes0.354
    10Female48Right MCAYesM3No0.4
    11Female73Right MCAYesNoYes0.315
    12Male58Right MCAYesNoYes0.41
    13Female48BAYesNoYes0.36
    14Male50BAYesNoNo0.401
    15Male60Right MCANoNoYes0.384
    16Male89Right MCAYesNoYes0.431
    • Note:—BA indicates basilar artery.

    • View popup
    Table 2:

    Attenuation measurements on the different series with mean values, SDs, upper/lower 95% CIs of rater 1, and results from Wilcoxon tests between residual clots and perfused vessels in the 10 patients with residual clots

    Hounsfield Attenuation (Mean)
    CTDEwVNCIM
    Clots58.88 ± 10.9850.50 ± 10.0853.72 ± 9.4216.02 ± 12.07
        Lower/upper 95% CI of mean55.05/70.6643.29/57.7146.98/60.467.39/24.65
    Vessels43.35 ± 5.5449.37 ± 7.4441.64 ± 7.8710.88 ± 11.35
        Lower/upper 95% CI of mean39.5/47.7242.37/53.7133.17/44.7910.55/15.13
    P values (Wilcoxon).0091a.4316.0020a.8457
    • ↵a Significant difference.

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    Table 3:

    Results from Wilcoxon tests between the different DECT series in clotted and perfused vessels of the 10 patients with residual clots

    P Values (Wilcoxon)
    ClotsVessels
    DEw and VNC.5703.0020a
    DEw and IM.0020a.0020a
    VNC and IM.0020a.0020a
    • ↵a Significant difference.

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    Table 4:

    Results from attenuation measurements of raters 1 and 2 and intraclass correlation on the different series

    Rater 1 (Mean)Rater 2 (Mean)Intraclass Correlation
    Clot
        CT58.88 ± 10.9856.57 ± 9.490.8244
        DEw50.50 ± 10.0854.53 ± 25.300.7599
        VNC53.72 ± 9.4254.43 ± 8.330.9133
        IM16.02 ± 12.0719.60 ± 36.080.65
    Vessel
        CT43.35 ± 5.5443.99 ± 5.740.8779
        DEw49.37 ± 7.4450.68 ± 10.050.7687
        VNC41.64 ± 7.8746.23 ± 5.630.6277
        IM11.22 ± 6.9010.88 ± 11.350.6682
    • Note:—CT indicates preinterventional CT.

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American Journal of Neuroradiology: 36 (8)
American Journal of Neuroradiology
Vol. 36, Issue 8
1 Aug 2015
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Cite this article
A.E. Grams, M. Knoflach, R. Rehwald, J. Willeit, M. Sojer, E.R. Gizewski, B. Glodny
Residual Thromboembolic Material in Cerebral Arteries after Endovascular Stroke Therapy Can Be Identified by Dual-Energy CT
American Journal of Neuroradiology Aug 2015, 36 (8) 1413-1418; DOI: 10.3174/ajnr.A4350

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Residual Thromboembolic Material in Cerebral Arteries after Endovascular Stroke Therapy Can Be Identified by Dual-Energy CT
A.E. Grams, M. Knoflach, R. Rehwald, J. Willeit, M. Sojer, E.R. Gizewski, B. Glodny
American Journal of Neuroradiology Aug 2015, 36 (8) 1413-1418; DOI: 10.3174/ajnr.A4350
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