Mechanical Thrombectomy with the Embolus Retriever with Interlinked Cages in Acute Ischemic Stroke: ERIC, the New Boy in the Class

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Fig 1.
Figure illustrating the differences in clot retainment between the outside of classic stent retrievers (A) and inside the cages of the ERIC device (B).
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Fig 2.
Flow chart of patient inclusion.

Table 1:

Baseline characteristics^{^a}

Characteristics	N = 316
Age (mean) (yr)	68.7 ± 13; range 27–94
Sex (male)	174 (55%)
Diabetes	38 (12%)
Hyperlipidemia	100 (32%)
Hypertension	183 (58%)
Known atrial fibrillation	84 (27%)
Prior stroke	39 (12%)
CCI 0	158 (50%)
CCI 1–3	137 (43%)
CCI 4–10	21 (7%)
IV rtPA	223 (71%)
Clot location
ICA-T	83 (26%)
M1	177 (56%)
M2	47 (15%)
Other	9 (3%)
NIHSS (mean)	16.9 ± 5; range, 0–28
Extracranial carotid stenting	64 (20%)
Onset to image (mean) (min)	97.8 ± 64; range, 10–517
Image to groin (mean) (min)	149.3 ± 62; range, 27–459
Onset to TICI (mean) (min)	325.0 ± 106; range, 102–900
General anesthesia	205 (65%)

Table 2:

Comparison of clinical and treatment characteristics before and after propensity score matching^{^a}

	Before Propensity Score Matching			After Propensity Score Matching
	ERIC (n = 59)	Non-ERIC (n = 257)	P Value	ERIC (n = 57)	Non-ERIC (n = 57)	P Value
Age (yr)	70.0	68.4	.41	69.7	70.1	.87
Sex (male)	29 (49%)	145 (56%)	.31	29 (51%)	31 (54%)	.85
CCI 0	27 (46%)	131 (51%)	.44	27 (47%)	28 (49%)	.50
CCI 1–3	26 (44%)	111 (43%)		25 (44%)	27 (47%)
CCI ≥4	6 (10%)	15 (6%)		5 (9%)	2 (4%)
Known atrial fibrillation	15 (25%)	69 (27%)	.87	14 (25%)	17 (30%)	.67
IV rtPA	39 (66%)	184 (72%)	.43	38 (67%)	41 (72%)	.69
Clot location
ICA-T	22 (37%)	61 (24%)	<.0001	22 (39%)	22 (39%)	.63
M1	19 (32%)	158 (61%)		17 (30%)	21 (37%)
M2	13 (22%)	34 (13%)		13 (23%)	12 (21%)
Other	5 (8%)	4 (2%)		Other: 5 (8%)	2 (3%)
NIHSS	17.4	16.8	.36	17.4	17.5	.91
Extracranial carotid stenting	13 (22%)	51 (20%)	.72	13 (23%)	10 (18%)	.64
Onset to image (min)	92.3	99.0	.51	92.6	98.7	.65
Image to groin (min)	167.0	145.3	.04	167.0	150.5	.20
General anesthesia	34 (58%)	171 (67%)	.23	33 (58%)	32 (56%)	1.00
Neurointerventionalist
1	38 (64%)	53 (21%)	<.0001	36 (63%)	28 (49%)	.51
2	15 (25%)	45 (18%)		15 (26%)	20 (35%)
3	4 (7%)	59 (23%)		4 (7%)	6 (11%)
4	0 (0%)	42 (16%)		0 (0%)	0 (0%)
5	2 (3%)	58 (23%)		2 (4%)	3 (5%)

Table 3:

Comparison of procedural and clinical outcome after propensity score matching for primary and time-sensitivity analysis^{^a}

	Primary Analysis		P Value	Time-Sensitivity Analysis		P Value
	ERIC (n = 57)	Non-ERIC (n = 57)	P Value	ERIC (n = 37)	Non-ERIC (n = 37)	P Value
TICI 2b–3	49 (86%)	46 (81%)		32 (86%)	30 (81%)
OR (95% CI)	1.46 (0.54–3.96)		.61	1.49 (0.43–5.22)		.75
mRS 0–2	26 (46%)	23 (40%)		17 (46%)	14 (38%)
OR (95% CI)	1.24 (0.59–2.61)		.71	1.56 (0.62–3.93)		.64
Mortality	11 (19%)	12 (21%)		7 (19%)	7 (19%)
OR (95% CI)	0.90 (0.36–2.24)		1.00	1.17 (0.39–3.45)		1.00
Procedural duration (min)	67.4	98.0		74.1	90.8
Mean difference (95% CI)	30.6 (8.0–53.2)		.009	16.6 (−7.8–41.1)		.18
No. of passes	2.5	3.1		2.5	3.4
Mean difference (95% CI)	0.6 (−0.1–1.3)		.11	0.9 (−0.2–2.0)		.10
Several devices needed	10 (18%)	22 (39%)		7 (19%)	16 (43%)
OR (95% CI)	0.34 (0.14–0.80)		.02	0.31 (0.11–0.87)		.04
Parenchymal hemorrhages	4 (7%)	8 (14%)		4 (11%)	2 (6%)
OR (95% CI)	0.46 (0.13–1.63)		.36	1.50 (0.24–9.55)		.67
Symptomatic hemorrhages	3 (5%)	9 (16%)		3 (8%)	4 (11%)
OR (95% CI)	0.30 (0.076–1.16)		.12	0.47 (0.08–2.74)		1.00
Distal embolism	1 (2%)	5 (9%)		1 (3%)	4 (11%)
OR (95% CI)	0.19 (0.02–1.64)		.21	0.23 (0.02–2.16)		.36
Procedural adverse events	16 (28%)	17 (30%)		11 (30%)	13 (35%)
OR (95% CI)	0.92 (0.41–2.06)		1.00	0.59 (0.22–1.63)		.80