Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy

L.L. Gramegna; A. Pisano; C. Testa; D.N. Manners; R. D'Angelo; E. Boschetti; F. Giancola; L. Pironi; L. Caporali; M. Capristo; M.L. Valentino; G. Plazzi; C. Casali; M.T. Dotti; G. Cenacchi; M. Hirano; C. Giordano; P. Parchi; R. Rinaldi; R. De Giorgio; R. Lodi; V. Carelli; C. Tonon

doi:10.3174/ajnr.A5507

Research ArticleAdult Brain

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Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy

L.L. Gramegna, A. Pisano, C. Testa, D.N. Manners, R. D'Angelo, E. Boschetti, F. Giancola, L. Pironi, L. Caporali, M. Capristo, M.L. Valentino, G. Plazzi, C. Casali, M.T. Dotti, G. Cenacchi, M. Hirano, C. Giordano, P. Parchi, R. Rinaldi, R. De Giorgio, R. Lodi, V. Carelli and C. Tonon

American Journal of Neuroradiology March 2018, 39 (3) 427-434; DOI: https://doi.org/10.3174/ajnr.A5507

L.L. Gramegna

aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

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A. Pisano

eDepartments of Radiology, Oncology, and Pathology (A.P., C.G.)

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C. Testa

aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)

bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

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D.N. Manners

aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

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R. D'Angelo

bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy

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E. Boschetti

dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy

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F. Giancola

dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy

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L. Pironi

dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy

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L. Caporali

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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M. Capristo

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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M.L. Valentino

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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G. Plazzi

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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C. Casali

fMedico-Surgical Sciences and Biotechnologies (C.C.), Sapienza, University of Rome, Rome, Italy

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M.T. Dotti

hDepartment of Medicine, Surgery, and Neuroscience (M.T.D.), University of Siena, Siena, Italy

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G. Cenacchi

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

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M. Hirano

iDepartment of Neurology (M.H.), Columbia University Medical Centre, New York, New York.

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C. Giordano

eDepartments of Radiology, Oncology, and Pathology (A.P., C.G.)

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P. Parchi

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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R. Rinaldi

bNeurology Unit (R.D., R.R.), S.Orsola-Malpighi Hospital, Bologna, Italy

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R. De Giorgio

dSurgical and Medical Sciences (E.B., F.G., L.P., R.D.G.), University of Bologna, Bologna, Italy

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R. Lodi

aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

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V. Carelli

cDepartments of Biomedical and Neuromotor Sciences (L.L.G., C.T., D.N.M., L.C., M.C., M.L.V., G.P., G.C., P.P., R.L., V.C., C.T.)

gIstituto di Ricovero e Cura a Carattere Scientifico Institute of Neurological Sciences (L.C., M.C., M.L.V., G.P., P.P., V.C.), Bologna, Italy

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C. Tonon

aFrom the Functional MR Unit (L.L.G., C.T., D.N.M., R.L., C.T.)

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Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy

American Journal of Neuroradiology Mar 2018, 39 (3) 427-434; DOI: 10.3174/ajnr.A5507

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Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy

American Journal of Neuroradiology Mar 2018, 39 (3) 427-434; DOI: 10.3174/ajnr.A5507

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