Article Figures & Data
Figures
- Fig 1.
A VOI was generated using a voxel-based signal intensity threshold method subsuming the entire region of FLAIR hyperintensity. Using coregistered images, we transferred the VOI to ADC for quantitative ADC analysis.
- Fig 2.
Study flow diagram.
- Fig 3.
A 34-year-old woman diagnosed with grade II oligodendroglioma. A, Axial FLAIR/ADC images from 4 sequential MR images are shown (upper row: FLAIR; lower row: ADC; from left to right: first scan after initial diagnosis and at 5, 9, and 14 months). Review of FLAIR images shows stable extent of tumor during the entire follow-up. B, Plotting the normalized ADC10 values demonstrates no significant decrease in ADC10 values, concordant with stability of the tumor.
- Fig 4.
A 73-year-old woman diagnosed with a grade II oligodendroglioma. A, Axial FLAIR/ADC images from 4 sequential scans are shown (upper row: FLAIR; lower row: ADC; from left to right: first scan after initial diagnosis and at 4, 8, and 28 months). Disease progression was diagnosed at 28 months on conventional imaging and confirmed by surgical pathology. B, Both normalized ADC10 and ADCmean ratios are plotted, demonstrating an interval decrease of ADC10 as early as 4 months following baseline examination, indicating eventual tumor progression. C, Histograms of quantitative normalized ratios of ADC10 and ADCmean for each MR imaging examination.
Tables
- Table 1:
Baseline and clinical data in patients with and without progression—univariate analysis
Patient Characteristics Total (n = 28) Progressed (n = 13) Stable (n = 15) P Value Age (mean) (SD) (yr) 50.4 (16.6) 49.1 (19.0) 51.6 (14.8) .70 Sex, male/female 14:14 7:6 7:8 .56 Initial tumor size (mean) (SD) (mL) 30.7 (33.8) 32.3 (26.3) 29.4 (40.1) .82 Tumor type, oligo/astro 19/9 9/4 10/5 .80 Follow-up time (mean) (range) (mo) 40.9 (12–109) 42.8 (12–89) 39.3 (12–109) .75 No. of MRIs/patient (mean) (SD) 8.8 (4.3) 9.8 (5.0) 7.9 (3.6) .26 Extent of initial tumor resection (No.) (>50% of initial volume) 15 (53.5%) 8 (61.5%) 7 (46.6%) .68 Note:—oligo indicates oligodendroglioma; astro, astrocytoma.
ADC Interval Change Stable Tumors (n = 15) Progressed (n = 13) P Value Overall Diagnostic Accuracy Mean Decrease 7/15 6/13 .8 50% Plateau/increase 8/15 7/13 10th percentile Decrease 3/15 12/13 <.001 86% Plateau/increase 12/15 1/13
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