Volumetry of Mesiotemporal Structures Reflects Serostatus in Patients with Limbic Encephalitis

Starplots showing hippocampal subfield volume differences between patients in the early group and controls. Z values reflect the hippocampal subfield volume difference between patients in the early group and controls in the affected and the unaffected hemispheric sides. Underlined words indicate statistical significance of the respective hippocampal subfield (P < .05) in post hoc tests between patients and controls following a multivariate linear model (see MATERIALS AND METHODS and supporting information in On-line Tables 3–8). A, Relative hippocampal subfield volumes of the affected and unaffected sides of GAD-LE. B, Relative hippocampal subfield volumes of the affected and unaffected sides of VGKC-LE. GC-ML-DG indicates granule cell layer of the dentate gyrus; HATA, hippocampus-amygdala transition area.

Decision tree classification. Decision tree classification between LGI1 and GAD using hippocampal subfield volumes from the hemisphere affected in the EEG in early-stage LE. A, Decision tree with importance of features. B, Histogram showing the number of label-shift permutations for each accuracy bin. The solid red line displays a fitted Gaussian curve describing the underlying probability density function. The dashed purple line marks the classifier performance on the real data. C, Starplot showing Z values of the hippocampal subfield volume differences between LGI1-LE and GAD-LE in the affected hemispheric side (see supporting information in On-line Tables 3 and 5 for statistics). HATA indicates hippocampus-amygdala transition area; GC-ML-DG, granule cell layer of the dentate gyrus.