Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • ASNR Foundation Special Collection
    • Most Impactful AJNR Articles
    • Photon-Counting CT
    • Spinal CSF Leak Articles (Jan 2020-June 2024)
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR is seeking candidates for the AJNR Podcast Editor. Read the position description.

Research ArticleAdult Brain
Open Access

Leptomeningeal Contrast Enhancement Is Related to Focal Cortical Thinning in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional MRI Study

N. Bergsland, D. Ramasamy, E. Tavazzi, D. Hojnacki, B. Weinstock-Guttman and R. Zivadinov
American Journal of Neuroradiology April 2019, 40 (4) 620-625; DOI: https://doi.org/10.3174/ajnr.A6011
N. Bergsland
aFrom the Buffalo Neuroimaging Analysis Center (N.B., D.R., E.T., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Bergsland
D. Ramasamy
aFrom the Buffalo Neuroimaging Analysis Center (N.B., D.R., E.T., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Ramasamy
E. Tavazzi
aFrom the Buffalo Neuroimaging Analysis Center (N.B., D.R., E.T., R.Z.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Tavazzi
D. Hojnacki
bJacobs Comprehensive MS Treatment and Research Center (D.H., B.W.-G.), Department of Neurology
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Hojnacki
B. Weinstock-Guttman
bJacobs Comprehensive MS Treatment and Research Center (D.H., B.W.-G.), Department of Neurology
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Weinstock-Guttman
R. Zivadinov
aFrom the Buffalo Neuroimaging Analysis Center (N.B., D.R., E.T., R.Z.)
cJacobs School of Medicine and Biomedical Sciences, Center for Biomedical Imaging at Clinical Translational Science Institute (R.Z.), University at Buffalo, State University of New York, Buffalo, New York.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Zivadinov
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

REFERENCES

  1. 1.↵
    1. Mahad DH,
    2. Trapp BD,
    3. Lassmann H
    . Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol 2015;14:183–93 doi:10.1016/S1474-4422(14)70256-X pmid:25772897
    CrossRefPubMed
  2. 2.↵
    1. Herranz E,
    2. Gianni C,
    3. Louapre C, et al
    . Neuroinflammatory component of gray matter pathology in multiple sclerosis. Ann Neurol 2016;80:776–90 doi:10.1002/ana.24791 pmid:27686563
    CrossRefPubMed
  3. 3.↵
    1. Magliozzi R,
    2. Howell O,
    3. Vora A, et al
    . Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain 2007;130:1089–104 pmid:17438020
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Lucchinetti CF,
    2. Popescu BF,
    3. Bunyan RF, et al
    . Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med 2011;365:2188–97 doi:10.1056/NEJMoa1100648 pmid:22150037
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Haider L,
    2. Zrzavy T,
    3. Hametner S, et al
    . The topography of demyelination and neurodegeneration in the multiple sclerosis brain. Brain 2016;139:807–15 doi:10.1093/brain/awv398 pmid:26912645
    CrossRefPubMed
  6. 6.↵
    1. Choi SR,
    2. Howell OW,
    3. Carassiti D, et al
    . Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain 2012;135:2925–37 doi:10.1093/brain/aws189 pmid:22907116
    CrossRefPubMedWeb of Science
  7. 7.↵
    1. Howell OW,
    2. Reeves CA,
    3. Nicholas R, et al
    . Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain 2011;134:2755–71 doi:10.1093/brain/awr182 pmid:21840891
    CrossRefPubMedWeb of Science
  8. 8.↵
    1. Popescu BF,
    2. Lucchinetti CF
    . Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurol 2012;12:11 doi:10.1186/1471-2377-12-11 pmid:22397318
    CrossRefPubMed
  9. 9.↵
    1. Serafini B,
    2. Rosicarelli B,
    3. Magliozzi R, et al
    . Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis. Brain Pathol 2004;14:164–74 doi:10.1111/j.1750-3639.2004.tb00049.x pmid:15193029
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Zurawski J,
    2. Lassmann H,
    3. Bakshi R
    . Use of magnetic resonance imaging to visualize leptomeningeal inflammation in patients with multiple sclerosis: a review. JAMA Neurol 2017;74:100–09 doi:10.1001/jamaneurol.2016.4237 pmid:27893883
    CrossRefPubMed
  11. 11.↵
    1. Absinta M,
    2. Vuolo L,
    3. Rao A, et al
    . Gadolinium-based MRI characterization of leptomeningeal inflammation in multiple sclerosis. Neurology 2015;85:18–28 doi:10.1212/WNL.0000000000001587 pmid:25888557
    Abstract/FREE Full Text
  12. 12.↵
    1. Harrison DM,
    2. Wang KY,
    3. Fiol J, et al
    . Leptomeningeal enhancement at 7T in multiple sclerosis: frequency, morphology, and relationship to cortical volume. J Neuroimaging 2017;27:461–68 doi:10.1111/jon.12444 pmid:28464368
    CrossRefPubMed
  13. 13.↵
    1. Zivadinov R,
    2. Ramasamy DP,
    3. Hagemeier J, et al
    . Evaluation of leptomeningeal contrast enhancement using pre-and postcontrast subtraction 3D-FLAIR imaging in multiple sclerosis. AJNR Am J Neuroradiol 2018;39:642–47 doi:10.3174/ajnr.A5541 pmid:29439125
    Abstract/FREE Full Text
  14. 14.↵
    1. Zivadinov R,
    2. Ramasamy DP,
    3. Vaneckova M, et al
    . Leptomeningeal contrast enhancement is associated with progression of cortical atrophy in MS: a retrospective, pilot, observational longitudinal study. Mult Scler 2017;23:1336–45 doi:10.1177/1352458516678083 pmid:27811339
    CrossRefPubMed
  15. 15.↵
    1. Makshakov G,
    2. Magonov E,
    3. Totolyan N, et al
    . Leptomeningeal contrast enhancement is associated with disability progression and grey matter atrophy in multiple sclerosis. Neurol Res Int 2017;2017:8652463 doi:10.1155/2017/8652463 pmid:29291134
    CrossRefPubMed
  16. 16.↵
    1. Bö L,
    2. Geurts JG,
    3. van der Valk P, et al
    . Lack of correlation between cortical demyelination and white matter pathologic changes in multiple sclerosis. Arch Neurol 2007;64:76–80 doi:10.1001/archneur.64.1.76 pmid:17210812
    CrossRefPubMedWeb of Science
  17. 17.↵
    1. Calabrese M,
    2. Seppi D,
    3. Romualdi C, et al
    . Gray matter pathology in MS: a 3-year longitudinal study in a pediatric population. AJNR Am J Neuroradiol 2012;33:1507–11 doi:10.3174/ajnr.A3011 pmid:22422186
    Abstract/FREE Full Text
  18. 18.↵
    1. Kappus N,
    2. Weinstock-Guttman B,
    3. Hagemeier J, et al
    . Cardiovascular risk factors are associated with increased lesion burden and brain atrophy in multiple sclerosis. J Neurol Neurosurg Psychiatry 2016;87:181–87 doi:10.1136/jnnp-2014-310051 pmid:25722366
    Abstract/FREE Full Text
  19. 19.↵
    1. Polman CH,
    2. Reingold SC,
    3. Banwell B, et al
    . Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 2011;69:292–302 doi:10.1002/ana.22366 pmid:21387374
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Dale AM,
    2. Fischl B,
    3. Sereno MI
    . Cortical surface-based analysis, I: segmentation and surface reconstruction. Neuroimage 1999;9:179–94 doi:10.1006/nimg.1998.0395 pmid:9931268
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Fischl B,
    2. Salat DH,
    3. Busa E, et al
    . Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 2002;33:341–55 doi:10.1016/S0896-6273(02)00569-X pmid:11832223
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Magon S,
    2. Gaetano L,
    3. Chakravarty MM, et al
    . White matter lesion filling improves the accuracy of cortical thickness measurements in multiple sclerosis patients: a longitudinal study. BMC Neurosci 2014;15:106 doi:10.1186/1471-2202-15-106 pmid:25200127
    CrossRefPubMed
  23. 23.↵
    1. Greve DN,
    2. Fischl B
    . Accurate and robust brain image alignment using boundary-based registration. Neuroimage 2009;48:63–72 doi:10.1016/j.neuroimage.2009.06.060 pmid:19573611
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Magliozzi R,
    2. Howell OW,
    3. Reeves C, et al
    . A gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol 2010;68:477–93 doi:10.1002/ana.22230 pmid:20976767
    CrossRefPubMedWeb of Science
  25. 25.↵
    1. Schläger C,
    2. Körner H,
    3. Krueger M, et al
    . Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid. Nature 2016;530:349–53 doi:10.1038/nature16939 pmid:26863192
    CrossRefPubMed
  26. 26.↵
    1. Sepulcre J,
    2. Goñi J,
    3. Masdeu JC, et al
    . Contribution of white matter lesions to gray matter atrophy in multiple sclerosis: evidence from voxel-based analysis of T1 lesions in the visual pathway. Arch Neurol 2009;66:173–79 doi:10.1001/archneurol.2008.562 pmid:19204153
    CrossRefPubMedWeb of Science
  27. 27.↵
    1. Bergsland N,
    2. Laganà MM,
    3. Tavazzi E, et al
    . Corticospinal tract integrity is related to primary motor cortex thinning in relapsing-remitting multiple sclerosis. Mult Scler 2015;21:1771–80 doi:10.1177/1352458515576985 pmid:25791368
    CrossRefPubMed
  28. 28.↵
    1. Steenwijk MD,
    2. Daams M,
    3. Pouwels PJ, et al
    . Unraveling the relationship between regional gray matter atrophy and pathology in connected white matter tracts in long-standing multiple sclerosis. Hum Brain Mapp 2015;36:1796–807 doi:10.1002/hbm.22738 pmid:25627545
    CrossRefPubMed
  29. 29.↵
    1. Jonas SN,
    2. Izbudak I,
    3. Frazier AA, et al
    . Longitudinal persistence of meningeal enhancement on postcontrast 7T 3D-FLAIR MRI in multiple sclerosis. AJNR Am J Neuroradiol 2018;39:1799–805 doi:10.3174/ajnr.A5796 pmid:30213813
    Abstract/FREE Full Text
  30. 30.↵
    1. Nielsen AS,
    2. Kinkel RP,
    3. Tinelli E, et al
    . Focal cortical lesion detection in multiple sclerosis: 3 Tesla DIR versus 7 Tesla FLASH-T2. J Magn Reson Imaging 2012;35:537–42 doi:10.1002/jmri.22847 pmid:22045554
    CrossRefPubMed
  31. 31.↵
    1. Harrison D,
    2. Jonas S,
    3. Izbudak I
    . Investigating the relationship between meningeal enhancement on 7T MRI and cortical gray matter lesions in multiple sclerosis. In: Proceedings of the Annual Congress of the European Committee for Treatment and Research in Multiple Sclerosis, Berlin, Germany. October 10–12, 2018; 489
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 40 (4)
American Journal of Neuroradiology
Vol. 40, Issue 4
1 Apr 2019
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Leptomeningeal Contrast Enhancement Is Related to Focal Cortical Thinning in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional MRI Study
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
N. Bergsland, D. Ramasamy, E. Tavazzi, D. Hojnacki, B. Weinstock-Guttman, R. Zivadinov
Leptomeningeal Contrast Enhancement Is Related to Focal Cortical Thinning in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional MRI Study
American Journal of Neuroradiology Apr 2019, 40 (4) 620-625; DOI: 10.3174/ajnr.A6011

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Leptomeningeal Contrast Enhancement Is Related to Focal Cortical Thinning in Relapsing-Remitting Multiple Sclerosis: A Cross-Sectional MRI Study
N. Bergsland, D. Ramasamy, E. Tavazzi, D. Hojnacki, B. Weinstock-Guttman, R. Zivadinov
American Journal of Neuroradiology Apr 2019, 40 (4) 620-625; DOI: 10.3174/ajnr.A6011
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • Materials and Methods
    • Results
    • Discussion
    • Conclusions
    • Footnotes
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • Alternative Venous Pathways: A Potential Key Imaging Feature for Early Diagnosis of Sturge-Weber Syndrome Type 1
  • Leptomeningeal Enhancement in Multiple Sclerosis and Other Neurological Diseases: A Systematic Review and Meta-Analysis
  • Imaging meningeal inflammation in CNS autoimmunity identifies a therapeutic role for BTK inhibition
  • Crossref (8)
  • Google Scholar

This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • The interplay between T helper cells and brain barriers in the pathogenesis of multiple sclerosis
    Gabriele Angelini, Alessandro Bani, Gabriela Constantin, Barbara Rossi
    Frontiers in Cellular Neuroscience 2023 17
  • Specific myeloid signatures in peripheral blood differentiate active and rare clinical phenotypes of multiple sclerosis
    Aigli G. Vakrakou, Nikolaos Paschalidis, Eleftherios Pavlos, Christina Giannouli, Dimitris Karathanasis, Xristina Tsipota, Georgios Velonakis, Christine Stadelmann-Nessler, Maria-Eleftheria Evangelopoulos, Leonidas Stefanis, Constantinos Kilidireas
    Frontiers in Immunology 2023 14
  • Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review
    Aleksandra Pogoda-Wesołowska, Angela Dziedzic, Karina Maciak, Adam Stȩpień, Marta Dziaduch, Joanna Saluk
    Frontiers in Molecular Neuroscience 2023 16
  • Alternative Venous Pathways: A Potential Key Imaging Feature for Early Diagnosis of Sturge-Weber Syndrome Type 1
    Carmen R. Cerron-Vela, Amirreza Manteghinejad, Simon M. Clifford, Savvas Andronikou
    American Journal of Neuroradiology 2025 46 1
  • Typical and Emerging Diagnostic MRI Features in Multiple Sclerosis
    Àlex Rovira, Cristina Auger, Sofía Sceppacuercia, Carlos Torres
    Canadian Association of Radiologists Journal 2025 76 1
  • Leptomeningeal B-cell follicles in multiple sclerosis: a role in the pathogenesis and prognostic value
    A.A. Abramova, I.V. Zakroyshchikova, I.A. Krotenkova, I. A. Kochergin, M. N. Zakharova
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2019 119 10
  • Leptomeningeal B-cell follicles in multiple sclerosis: a role in the pathogenesis and prognostic value
    A.A. Abramova, I.V. Zakroyshchikova, I.A. Krotenkova, I. A. Kochergin, M. N. Zakharova
    Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova 2019 119 10
  • Multiple Sklerose
    2022

More in this TOC Section

  • Diagnostic Neuroradiology of Monoclonal Antibodies
  • Clinical Outcomes After Chiari I Decompression
  • Segmentation of Brain Metastases with BLAST
Show more Adult Brain

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

Special Collections

  • AJNR Awards
  • ASNR Foundation Special Collection
  • Most Impactful AJNR Articles
  • Photon-Counting CT
  • Spinal CSF Leak Articles (Jan 2020-June 2024)

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire