Article Figures & Data
Figures
- Fig 1.
Axial T2, b = 1000, and ADC map of an OPSCC of the right palatine tonsil.
- Fig 2.
Kaplan-Meier curve showing better progression-free survival in the HPV–positive group (P value, log-rank test < .0001).
- Fig 3.
Kaplan-Meier curve showing better overall survival in the HPV–positive group (P value, log–rank test < .0001).
- Fig 4.
Kaplan-Meier curve showing better progression-free survival in the group with ADC lower than the median value (P value, log–rank test < .0001).
Tables
Total (n = 59) HPV+ (n = 28) HPV– (n = 31) P Value Age (yr) 66.3 66.2 67.4 .9 Sex Male 43 19 24 .41 Female 16 9 7 Smoker 34/59 8/28 26/31 <.0001 Site 38, Palatine tonsil 20, Palatine tonsil 18, Palatine tonsil .61 17, Tongue base 7, Tongue base 10, Tongue base 3, Soft palate 1, Soft palate 2, Soft palate 1, Posterior wall 1, Posterior wall TNM classification T T2 = 25 T2 = 16 T2 = 9 .08 T3 = 2 T3 = 1 T3 = 1 T4 = 32 T4 = 11 T4 = 21 (16, T4a; 5, T4b) N N0 = 14 N0 = 7 N0 = 7 .002 N1 = 15 N1 = 13 N1 = 2 N2 = 18 N2 = 6 N2 = 12 (8, N2b; 4, N2c) N3 = 12 N3 = 2 N3 = 10 (N3b = 10) M M0 = 57 M0 = 27 M0 = 30 .14 M1 = 2 M1 = 1 M1 = 1 Note:—HPV+ indicates human papillomavirus–positive; HPV–, human papillomavirus–negative.
HR 95% CI P Value Corrected P Value PFS, univariate analysis HPV 0.27 0.11–0.67 .01 .03 Mean ADC (961.37 ± 184) 1.00 1.00–1.00 .01 .03 SD ADC (186.64 ± 54.32) 1.00 0.9966–1.0115 .29 .44 Kurtosis ADC (2.08 ± 2.17) 1.08 0.87–1.34 .50 .50 Skewness ADC (0.86 ± 0.76) 0.81 0.45–1.45 .48 .50 Entropy ADC (184 ± 0.5) 1.90 0.78–4.67 .16 .32 OS, univariate analysis HPV 0.21 0.06–0.76 .02 .10 Mean ADC 1.00 0.999–1.004 .2 .34 SD ADC 0.1 0.985–1.005 .34 .34 Kurtosis ADC 1.15 0.89–1.15 .3 .34 Skewness ADC 0.69 0.35–1.35 .28 .34 Entropy ADC 2.75 0.9–8.43 .08 .23 Note:—HR indicates hazard ratio.
ADC HPV-Positive P Value HPV-Negative P Value DFS Mean (961.37 ± 184) .27 .40 SD (186.64 ± 54.32) .79 .79 Kurtosis (2.08 ± 2.17) .17 .98 Skewness (0.86 ± 0.76) .53 .79 Entropy (184 ± 0.5) .63 .24 OS Mean .14 .37 SD .24 .13 Kurtosis .57 .14 Skewness .06 .65 Entropy .19 .01a Note:—DFS indicates disease-free survival.
↵a OR = 4.8461; 95% CI, 1.3507–17.3868.
- Table 4:
Studies investigating the relationship between pretreatment ADC and outcome after chemoradiation therapy in head and neck cancer
Reference Year of Publication No. of Patients No. of Patients with OPSCC HPV Status Available High ADC Associated with Kim et al15 2009 33 22 N Poor outcome Hatakenaka et al16 2011 57 22 N Poor outcome Ohnishi et al17 2011 64 30 N Poor outcome Srinivasan et al18 2012 20 11 N Poor outcome Nakajo et al19 2012 26 8 N Better outcome King et al20 2013 37 14 N Poor outcome Chawla et al21 2013 32 9 N Poor outcome Lambrecht et al22 2014 161 85 N Poor outcome Ng et al23 2016 69 37 N Poor outcome Noij et al24 2015 78 40 N Poor outcome Preda et al25 2016 57 11 Na Poor outcome Marzi et al26 2017 34 14 N/Yb Poor outcome Lombardi et al27 2017 47 19 N Poor outcome Martens et al28 2019 134 96 Y Poor outcomec
