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Research ArticleAdult Brain
Open Access

Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis

E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman and R. Zivadinov
American Journal of Neuroradiology September 2020, 41 (9) 1577-1583; DOI: https://doi.org/10.3174/ajnr.A6684
E. Ghione
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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  • ORCID record for E. Ghione
N. Bergsland
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
dIRCCS (N.B.), Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
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M.G. Dwyer
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York
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J. Hagemeier
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D. Jakimovski
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D.P. Ramasamy
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
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D. Hojnacki
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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A.A. Lizarraga
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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C. Kolb
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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S. Eckert
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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B. Weinstock-Guttman
bDepartment of Neurology (D.H., A.A.L., C.K., S.E., B.W.-G.), Jacobs Comprehensive MS Treatment and Research Center, Jacobs School of Medicine and Biomedical Sciences
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R. Zivadinov
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., D.P.R., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at the Clinical Translational Science Institute (M.G.D., R.Z.),University at Buffalo, State University of New York, Buffalo, New York
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Figures

  • FIG 1.
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    FIG 1.

    Change in lateral ventricle volume in patients with MS disability progression and disability improvement. In the upper and lower rows are shown in patients with MS with disability improvement and disability progression, respectively. From left to right are baseline and followup T2-FLAIR images and images of NeuroSTREAM LVV (highlighted in red) segmentation at baseline and at follow-up. Please note higher annualized percentage LVV change in patients with MS with disability progression (5.7%) compared with disability improvement (1.1%).

  • FIG 2.
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    FIG 2.

    Change in whole-brain volume in patients with MS with disability improvement and disability progression. In the upper and lower rows are shown patients with MS with disability improvement and disability progression, respectively. From left to right are baseline and follow-up 3D-T1WI, and a SIENA brain volume change edge map showing areas of atrophy (in blue-light blue) and growth (in red-yellow). Please note the higher annualized PBVC rate in disability progressed (−2.4%) compared with disability improved (−0.5%).

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American Journal of Neuroradiology: 41 (9)
American Journal of Neuroradiology
Vol. 41, Issue 9
1 Sep 2020
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Cite this article
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman, R. Zivadinov
Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis
American Journal of Neuroradiology Sep 2020, 41 (9) 1577-1583; DOI: 10.3174/ajnr.A6684

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Disability Improvement Is Associated with Less Brain Atrophy Development in Multiple Sclerosis
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, D.P. Ramasamy, D. Hojnacki, A.A. Lizarraga, C. Kolb, S. Eckert, B. Weinstock-Guttman, R. Zivadinov
American Journal of Neuroradiology Sep 2020, 41 (9) 1577-1583; DOI: 10.3174/ajnr.A6684
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This article has been cited by the following articles in journals that are participating in Crossref Cited-by Linking.

  • Thalamic atrophy measured by artificial intelligence in a multicentre clinical routine real-world study is associated with disability progression
    Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Ralph H B Benedict, Jon Riolo, Diego Silva, Michael G Dwyer
    Journal of Neurology, Neurosurgery & Psychiatry 2022 93 10
  • Brain atrophy and lesion burden are associated with disability progression in a multiple sclerosis real-world dataset using only T2-FLAIR: The NeuroSTREAM MSBase study
    Michael Barnett, Niels Bergsland, Bianca Weinstock-Guttman, Helmut Butzkueven, Tomas Kalincik, Patricia Desmond, Frank Gaillard, Vincent van Pesch, Serkan Ozakbas, Juan Ignacio Rojas, Cavit Boz, Ayse Altintas, Chenyu Wang, Michael G. Dwyer, Suzie Yang, Dejan Jakimovski, Kain Kyle, Deepa P. Ramasamy, Robert Zivadinov
    NeuroImage: Clinical 2021 32
  • Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis
    Robert Zivadinov, Niels Bergsland, Dejan Jakimovski, Bianca Weinstock-Guttman, Lorena Lorefice, Menno M. Schoonheim, Sarah A. Morrow, Mary Ann Picone, Gabriel Pardo, Myassar Zarif, Mark Gudesblatt, Jacqueline A. Nicholas, Andrew Smith, Samuel Hunter, Stephen Newman, Mahmoud A. AbdelRazek, Ina Hoti, Jon Riolo, Diego Silva, Tom A. Fuchs, Michael G. Dwyer, Ralph HB. Benedict
    NeuroImage: Clinical 2024 42
  • Brain atrophy assessment in multiple sclerosis: technical– and subject-related barriers for translation to real-world application in individual subjects
    Robert Zivadinov, Ashley Tranquille, Jack A. Reeves, Michael G. Dwyer, Niels Bergsland
    Expert Review of Neurotherapeutics 2024 24 11

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