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Research ArticleNeurodegenerative Disorder Imaging

Alterations of Microstructure and Sodium Homeostasis in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI and Sodium MRI Study

M.M. El Mendili, A.-M. Grapperon, R. Dintrich, J.-P Stellmann, J.-P. Ranjeva, M. Guye, A. Verschueren, S. Attarian and W. Zaaraoui
American Journal of Neuroradiology July 2022, 43 (7) 984-990; DOI: https://doi.org/10.3174/ajnr.A7559
M.M. El Mendili
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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  • ORCID record for M.M. El Mendili
A.-M. Grapperon
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
cAPHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France
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R. Dintrich
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
cAPHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France
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  • ORCID record for R. Dintrich
J.-P Stellmann
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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J.-P. Ranjeva
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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M. Guye
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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A. Verschueren
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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S. Attarian
cAPHM, Hôpital de la Timone (A.-M.G., R.D., S.A.), Referral Centre for Neuromuscular Diseases and ALS, Marseille, France
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W. Zaaraoui
aFrom the Aix Marseille University (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), Centre national de la recherche scientifique, The Center for Magnetic Resonance in Biology and Medicine, Marseille, France
bAPHM, Hopital de la Timone (M.M.E.M., A.-M.G., R.D., J.-P.S., J.-P.R., M.G., A.V., W.Z.), CEMEREM, Marseille, France
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American Journal of Neuroradiology: 43 (7)
American Journal of Neuroradiology
Vol. 43, Issue 7
1 Jul 2022
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Cite this article
M.M. El Mendili, A.-M. Grapperon, R. Dintrich, J.-P Stellmann, J.-P. Ranjeva, M. Guye, A. Verschueren, S. Attarian, W. Zaaraoui
Alterations of Microstructure and Sodium Homeostasis in Fast Amyotrophic Lateral Sclerosis Progressors: A Brain DTI and Sodium MRI Study
American Journal of Neuroradiology Jul 2022, 43 (7) 984-990; DOI: 10.3174/ajnr.A7559

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Microstructure Changes in ALS Progressors
M.M. El Mendili, A.-M. Grapperon, R. Dintrich, J.-P Stellmann, J.-P. Ranjeva, M. Guye, A. Verschueren, S. Attarian, W. Zaaraoui
American Journal of Neuroradiology Jul 2022, 43 (7) 984-990; DOI: 10.3174/ajnr.A7559
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  • Recent technical developments and clinical research applications of sodium (23Na) MRI
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  • MRI biomarkers for memory-related impairment in amyotrophic lateral sclerosis: a systematic review
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    Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 2023 24 7-8
  • Association between brain and upper cervical spinal cord atrophy assessed by MRI and disease aggressiveness in amyotrophic lateral sclerosis
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  • Thalamic Alterations in Motor Neuron Diseases: A Systematic Review of MRI Findings
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    Exploration of Neuroprotective Therapy 2023
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    Zheqi Xu, Renshi Xu
    Reviews in the Neurosciences 2024 35 8
  • Diffusion tensor imaging biomarkers and clinical assessments in amyotrophic lateral sclerosis (ALS) patients: an exploratory study
    Saharnaz Pezeshgi, Sadegh Ghaderi, Sana Mohammadi, Narges Karimi, Bentolhoda Ziaadini, Mahdi Mohammadi, Farzad Fatehi
    Annals of Medicine & Surgery 2024 86 9
  • In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain 23Na MRI study
    Aude-Marie Grapperon, Mohamed Mounir El Mendili, Adil Maarouf, Jean-Philippe Ranjeva, Maxime Guye, Annie Verschueren, Shahram Attarian, Wafaa Zaaraoui, Belgin Sever
    PLOS ONE 2025 20 1
  • Polyacrylamide Gel Calibration Phantoms for Quantification in Sodium MRI
    Samuel Rot, Aaron Oliver‐Taylor, Rebecca R. Baker, Jennifer A. Steeden, Xavier Golay, Bhavana S. Solanky, Claudia A. M. Gandini Wheeler‐Kingshott
    NMR in Biomedicine 2025 38 6

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