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Research ArticleAdult Brain
Open Access

Artificial Intelligence–Assisted Evaluation of the Spatial Relationship between Brain Arteriovenous Malformations and the Corticospinal Tract to Predict Postsurgical Motor Defects

Y. Jiao, J. Zhang, X. Yang, T. Zhan, Z. Wu, Y. Li, S. Zhao, H. Li, J. Weng, R. Huo, J. Wang, H. Xu, Y. Sun, S. Wang and Y. Cao
American Journal of Neuroradiology January 2023, 44 (1) 17-25; DOI: https://doi.org/10.3174/ajnr.A7735
Y. Jiao
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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J. Zhang
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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X. Yang
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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T. Zhan
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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Z. Wu
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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Y. Li
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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S. Zhao
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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H. Li
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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J. Weng
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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R. Huo
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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J. Wang
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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H. Xu
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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Y. Sun
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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S. Wang
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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Y. Cao
aFrom the Department of Neurosurgery (Y.J., J.Z., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing Tiantan Hospital, Capital Medical University, Beijing, China
bChina National Clinical Research Center for Neurological Diseases (Y.J., J.Z., X.Y., T.Z., Z.W., Y.L., S.Z., H.L., J. Weng, R.H., J. Wang, H.X., Y.S., S.W., Y.C.), Beijing, China
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  • FIG 1.
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    FIG 1.

    Flow diagram of patient selection, AI-based indicator calculation, ML model development, and predictive ability evaluation. AI-based indicators include FN5mm/50mm, FN10mm/50mm, FP5mm/50mm, and FP10mm/50mm. Clinical variables include age, sex, side, lobe, size, deep perforating artery supply, deep venous drainage, hemorrhage, seizure, and S-M grading score. LASSO indicates least absolute shrinkage and selection operator.

  • FIG 2.
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    FIG 2.

    The workflow of segmentation, fiber tracking, and registration. Segmentation and fiber tracking were performed by the algorithm independently on TOF-MRA and DTI scans. The CSTs tracked on DTI scans were registered to TOF-MRA with BAVM segmentation to calculate the AI-based indicators.

  • FIG 3.
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    FIG 3.

    Schematic diagram of AI-based indicator calculation. The letters a–h indicate CSTs. The red, green, and blue circles indicate the borders of the BAVM lesion and the border with radii extended by the dilation algorithm to 10 and 50mm from the lesion, respectively. Letters a–b indicate CSTs within 10 mm of the border of the BAVM lesion. Letters a–d indicate CSTs within 50mm from the border of the BAVM lesion. Na-b and Na-d indicate the number of fibers between a and b and between a and d, respectively. Pa-b and Pa’-d indicate the sum of voxel points of fibers between a and b and between a and d, respectively.

  • FIG 4.
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    FIG 4.

    Results of feature screening of the ML model and different predictive methods in predicting postsurgical MDs. A, Result of feature screening with LASSO. The FN10mm/50mm, diffuseness, and S-M score were selected for ML model building. The values in every square indicate the Pearson coefficient between every 2 features. B, ROC curves of different algorithms for the ML model in prediction. C, ROC curves of FN10mm/50mm, LCDAI, S-M score, and HDVL score in prediction. D, ROC curves of FN10mm/50mm and the ML model in prediction. RF indicates random forest; SVM, support vector machine; XGB, XGBoost.

Tables

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    Table 1:

    Baseline characteristics of patients with BAVM

    Total Patients (n = 83)
    Age (mean) (yr)30.2 (SD, 11.5)
    Sex (No.) (%)
     Male53 (62.4)
     Female30 (37.6)
    Lobe (No.) (%)
     Frontal37 (44.6)
     Temporal18 (21.7)
     Parietal18 (21.7)
     Occipital8 (9.6)
     Insula2 (2.4)
    Size (mean) (mm)35.1 (SD, 11.4)
    Deep perforating artery supply (No.) (%)22 (26.5)
    Deep venous drainage (No.) (%)7 (8.4)
    Diffuse nidus (No.) (%)25 (30.1)
    LCDAI (mean) (mm)4.3 (SD, 5.1)
    Hemorrhage (No.) (%)33 (39.8)
    Seizure (No.) (%)41 (49.4)
    S-M score (No.) (%)2.4 (SD, 0.9)
    • View popup
    Table 2:

    Values of the calculated AI-based indicators

    Postsurgical MDs
    YesNo
    FN5mm/50mm (mean)0.24 (SD, 0.24)0.03 (SD, 0.06)
    FN10mm/50mm (mean)0.37 (SD, 0.27)0.06 (SD, 0.08)
    FP5mm/50mm (mean)0.06 (SD, 0.10)0.01 (SD, 0.02)
    FP10mm/50mm (mean)0.10 (SD, 0.12)0.02 (SD, 0.05)
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American Journal of Neuroradiology: 44 (1)
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Y. Jiao, J. Zhang, X. Yang, T. Zhan, Z. Wu, Y. Li, S. Zhao, H. Li, J. Weng, R. Huo, J. Wang, H. Xu, Y. Sun, S. Wang, Y. Cao
Artificial Intelligence–Assisted Evaluation of the Spatial Relationship between Brain Arteriovenous Malformations and the Corticospinal Tract to Predict Postsurgical Motor Defects
American Journal of Neuroradiology Jan 2023, 44 (1) 17-25; DOI: 10.3174/ajnr.A7735

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AI for AVM Involving Corticospinal Tract
Y. Jiao, J. Zhang, X. Yang, T. Zhan, Z. Wu, Y. Li, S. Zhao, H. Li, J. Weng, R. Huo, J. Wang, H. Xu, Y. Sun, S. Wang, Y. Cao
American Journal of Neuroradiology Jan 2023, 44 (1) 17-25; DOI: 10.3174/ajnr.A7735
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