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Various CTP metrics are used as biomarkers of ischemia and clinical outcomes in some patients undergoing EVT. This post hoc analysis of the Safety and Efficacy of Nerinetide in Subjects Undergoing Endovascular Thrombectomy for Stroke (ESCAPE-NA1) trial shows that patients having undergone EVT with baseline small CTP lesion volumes have a better clinical outcome compared with those with larger CTP lesions. However, CTP was not able to elucidate why some patients have poor outcomes despite near-complete recanalization.

The Bern score quantitatively characterizes brain MR imaging changes in spontaneous intracranial hypotension. This imaging biomarker was shown to have a low correlation with clinical headache severity and, therefore, imaging findings in isolation may have limited utility as primary outcome measures when assessing treatment response.