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Research ArticleADULT BRAIN
Open Access

Cerebellar Hypoperfusion in Migraine Attack: Incidence and Significance

F. Kellner-Weldon, M. El-Koussy, S. Jung, M. Jossen, P.P. Klinger-Gratz and R. Wiest
American Journal of Neuroradiology January 2018, DOI: https://doi.org/10.3174/ajnr.A5508
F. Kellner-Weldon
aFrom the Support Center for Advanced Neuroimaging (F.K.-W., M.E.-K., M.J., P.P.K.-G., R.W.), Institute for Diagnostic and Interventional Neuroradiology
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  • ORCID record for F. Kellner-Weldon
M. El-Koussy
aFrom the Support Center for Advanced Neuroimaging (F.K.-W., M.E.-K., M.J., P.P.K.-G., R.W.), Institute for Diagnostic and Interventional Neuroradiology
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S. Jung
bDepartment of Neurology (S.J.), University Hospital Inselspital, Bern, Switzerland
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M. Jossen
aFrom the Support Center for Advanced Neuroimaging (F.K.-W., M.E.-K., M.J., P.P.K.-G., R.W.), Institute for Diagnostic and Interventional Neuroradiology
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P.P. Klinger-Gratz
aFrom the Support Center for Advanced Neuroimaging (F.K.-W., M.E.-K., M.J., P.P.K.-G., R.W.), Institute for Diagnostic and Interventional Neuroradiology
cDepartment of Radiology (P.P.K.-G.), University of Basel, Basel, Switzerland.
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R. Wiest
aFrom the Support Center for Advanced Neuroimaging (F.K.-W., M.E.-K., M.J., P.P.K.-G., R.W.), Institute for Diagnostic and Interventional Neuroradiology
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  • Fig 1.
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    Fig 1.

    ROI analysis for perfusion parameters: CER indicates cerebellum; Put, putamen; I, insula; T, thalamus; A, arterial territory of the anterior cerebral artery; M, arterial territory of the middle cerebral artery; P, arterial territory of the posterior cerebral artery; PREC, precentral gyrus; POSTC, postcentral gyrus.

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    Fig 2.

    CCD in a 14-year-old girl presenting with MwA and CCD. Slices A and C show rCBF images of the infra- and supratentorial brain, and slices B and D, rCBV images respectively. The patient presented with HCH in the right cerebellum with overt hemispheric perfusion asymmetry. Fourteen of 17 supratentorial ROIs in the left supratentorial hemisphere exceeded the AI threshold with lateralization of hypoperfusion contralateral to the cerebellum. Bars indicate relative values for CBV and CBF.

Tables

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    Table 1:

    Clinical characteristics

    Predominant SymptomAbnormal PerfusionNormal Perfusion
    n = 23%n = 83%
    Headache2191.36957.3
    Aura symptoms2295.77663.1
        Visual1043.54436.5
        Sensory1773.93730.7
        Motor834.82218.3
        Language1147.81613.3
    • View popup
    Table 2:

    Predominant clinical symptoms in patients with abnormal cortical perfusion

    Predominant SymptomPatients with OligemiaHCH (CCD Subgroup)Non-HCH
    n = 23%n = 12 (9)%n = 11%
    Headache2191.310 (7)43.5 (30.4)1147.8
    Aura symptoms2295.712 (9)52.2 (39.1)1043.5
        Visual1043.55 (2)21.7 (8.7)521.7
        Sensory1773.97 (5)30.4 (21.7)1043.5
        Motor834.84 (4)17.4 (17.4)417.4
        Language1147.86 (6)26.1 (26.1)521.7
    • View popup
    Table 3:

    The number of ROIs with an AI of > 10% in supratentorial oligemia (maximum, 17 per patient), in the group with hemispheric cerebellar hypoperfusion (154/204) and in the group with symmetric cerebellar perfusion (145/187)

    Abnormal ROIs (AI > 10%)
    Patients with Hemispheric Cerebellar Hypoperfusion (n = 12)Patients with Symmetric Cerebellar Perfusion (n = 11)
    rCBF (No.)
        Total No. (%)154 (75.5)145 (77.5)
        Contralateral103
        Ipsilateral51
    rCBV (No.)
        Total No. (%)155 (75.5)139 (74.3)
        Contralateral101
        Ipsilateral54
    • View popup
    Table 4:

    Mean AI for hypoperfused cerebellar hemisphere and non-HCH (rCBF and rCBV)a

    AI Absolute Values (%)P Value
    Group HCH (n = 12)Group Non-HCH (n = 11)
    MeanSDMeanSD
    rCBF supratentorial27.606.8526.306.66.51
    rCBV supratentorial26.756.6624.646.27.48
    rCBF infratentorial30.5616.774.243.23<.001
    rCBV infratentorial25.6916.004.022.53<.001
    • ↵a Significant differences were noted only for infratentorial ROIs.

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Cite this article
F. Kellner-Weldon, M. El-Koussy, S. Jung, M. Jossen, P.P. Klinger-Gratz, R. Wiest
Cerebellar Hypoperfusion in Migraine Attack: Incidence and Significance
American Journal of Neuroradiology Jan 2018, DOI: 10.3174/ajnr.A5508

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Cerebellar Hypoperfusion in Migraine Attack: Incidence and Significance
F. Kellner-Weldon, M. El-Koussy, S. Jung, M. Jossen, P.P. Klinger-Gratz, R. Wiest
American Journal of Neuroradiology Jan 2018, DOI: 10.3174/ajnr.A5508
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