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Research ArticleBRAIN

Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis

Yulin Ge, Robert I. Grossman, James S. Babb, Marcie L. Rabin, Lois J. Mannon and Dennis L. Kolson
American Journal of Neuroradiology September 2002, 23 (8) 1334-1341;
Yulin Ge
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Robert I. Grossman
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James S. Babb
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Marcie L. Rabin
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Lois J. Mannon
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Dennis L. Kolson
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References

  1. ↵
    Reiss AL, Abrams MT, Singer HS, Ross JL, Denckla MB. Brain development, gender and IQ in children: a volumetric imaging study. Brain 1996;119:1763–1774
    Abstract/FREE Full Text
  2. ↵
    Giedd JN, Snell JW, Lange N, et al. Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb Cortex 1996;6:551–560
    Abstract/FREE Full Text
  3. ↵
    Coffey CE, Wilkinson WE, Parashos IA, et al. Quantitative cerebral anatomy of the aging human brain: a cross-sectional study using magnetic resonance imaging. Neurology 1992;42:527–536
    Abstract/FREE Full Text
  4. Murphy DGM, DeCarli C, Schapiro MB, Rapoport SI, Horwitz B. Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging. Arch Neurol 1992;49:839–845
    CrossRefPubMedWeb of Science
  5. Kikinis R, Shenton ME, Gerig G, et al. Routine quantitative analysis of brain and cerebrospinal fluid spaces with MR imaging. J Magn Reson Imaging 1992;2:619–629
    PubMedWeb of Science
  6. ↵
    Filipek PA, Richelme C, Kenndy DN, Caviness VS Jr. The young adult human brain: an MRI-based morphometric analysis. Cereb Cortex 1994;4:344–360
    Abstract/FREE Full Text
  7. ↵
    Salonen O, Autti T, Raininko R, Ylikoski A, Erkinjuntti T. MRI of the brain in neurologically healthy middle-aged and elderly individuals. Neuroradiology 1997;39:537–545
    CrossRefPubMedWeb of Science
  8. ↵
    Jack CR Jr., Petersen RC, Xu Y, et al. Rate of medial temporal lobe atrophy in typical aging and Alzheimer’s disease. Neurology 1998;51:993–999
    Abstract/FREE Full Text
  9. ↵
    Barber R, Scheltens P, Gholkar A, et al. White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer’s disease, vascular dementia, and normal aging. J Neurol Neurosurg Psychiatry 1999;67:66–72
    Abstract/FREE Full Text
  10. ↵
    Loevner LA, Grossman RI, Cohen JA, Lexa FJ, Kessler D, Kolson DL. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. Radiology 1995;196:511–515
    PubMedWeb of Science
  11. Prager JM, Rosenblum JD, Huddle DC, Diamond CK, Metz CE. The magnetization transfer effect in cerebral infarction. AJNR Am J Neuroradiol 1994;15:1497–1500
    Abstract/FREE Full Text
  12. ↵
    Kasner SE, Galetta SL, McGowan JC, Grossman RI. Magnetization transfer imaging in progressive multifocal leukoencephalopathy. Neurology 1997;48:534–536
    Abstract/FREE Full Text
  13. ↵
    Boorstein JM, Wong KT, Grossman RI, Bolinger L, McGowan JC. Metastatic lesions of the brain: imaging with magnetization transfer. Radiology 1994;191:799–803
    PubMed
  14. ↵
    Wong KT, Grossman RI, Boorstein JM, Lexa FJ, McGowan JC. Magnetization transfer imaging of periventricular hyperintense white matter in the elderly. AJNR Am J Neuroradiol 1995;16:253–258
    Abstract/FREE Full Text
  15. ↵
    van Buchem MA, McGowan JC, Kolson DL, Polsansky M, Grossman RI. Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magn Reson Med 1996;36:632–636
    PubMedWeb of Science
  16. ↵
    Phillips MD, Grossman RI, Miki Y, et al. Comparison of T2 lesion volume on magnetization transfer ratio histogram analysis and of lesion burden in patients with multiple sclerosis. AJNR Am J Neuroradiol 1998;19:1055–1060
    Abstract
  17. ↵
    Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ, Kolson DL. Age-related gray matter and white matter changes with aging in healthy adults, I: Quantitative volumetric MR imaging analysis. AJNR. •••.
  18. ↵
    Forsen S, Hoffman RA. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J Chem Phys 1964;39:2892–2901
  19. ↵
    Wolff SD, Balaban RS. Magnetization transfer imaging: practical aspects and clinical applications. Radiology 1994;192:593–599
    PubMedWeb of Science
  20. ↵
    Engelbrecht V, Rassek M, Presis S, Wald C, Modder U. Age-dependent changes in magnetization transfer contrast of white matter in the pediatric brain. AJNR Am J Neuroradiol 1998;19:1923–1929
    Abstract
  21. ↵
    Dobbing J, Sands J. Quantitative growth and development of human brain. Arch Dis Child 1973;48:757–767
    Abstract/FREE Full Text
  22. ↵
    Kinney HC, Karthigasan J, Borenshteyn NI, Flax JD, Kirschner DA. Myelination in the developing human brain: biochemical correlates. Neurochem Res 1994;19:983–996
    CrossRefPubMedWeb of Science
  23. ↵
    Hofman PA, Kemerink GJ, Jolles J, Wilmink JT. Quantitative analysis of magnetization transfer images of the brain: effect of closed head injury, age and sex on white matter. Magn Reson Med 1999;42:803–806
    CrossRefPubMedWeb of Science
  24. ↵
    Tanabe JL, Ezekiel F, Jagust WJ, et al. Magnetization transfer ratio of white matter hyperintensities in subcortical ischemic vascular dementia. AJNR Am J Neuroradiol 1999;20:839–844
    Abstract/FREE Full Text
  25. ↵
    Pfefferbaum A, Sullivan EV, Heduhus M, Lim KO, Adalsteinsson EA, Moseley M. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magn Reson Med 2000;44:259–268
    CrossRefPubMedWeb of Science
  26. ↵
    Mehta RC, Pike GB, Enzman DR. Magnetization transfer MR of the normal adult brain. AJNR Am J Neuroradiol 1995;16:2085–2091
    Abstract
  27. ↵
    Finelli DA. Magnetization transfer in neuroimaging. Magn Reson Imaging Clin North Am 1998;6:31–52
  28. ↵
    Finelli DA. Reed DR. Flip angle dependence of experimentally determined T1sat and apparent magnetization transfer rate constants. J Magn Reson Imaging 1998;8:548–553
    CrossRefPubMed
  29. ↵
    Melhem ER, Benson ML, Beauchamp NJ, Lee RR. Cervical spondylosis: three-dimensional gradient-echo MR with magnetization transfer. AJNR Am J Neuroradiol 1996;17:705–711
    Abstract
  30. ↵
    Rovaris M, Viti B, Ciboddo G, et al. Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study. J Neurol Neurosurg Psychiatry 2000;68:170–177
    Abstract/FREE Full Text
  31. ↵
    Filippi M. Magnetization transfer imaging to monitor the evolution of individual multiple sclerosis lesions. Neurology 1999;53:S18–S22
  32. ↵
    Ge Y, Grossman RI, Udupa JK, Babb JS, Kolson DL, McGowan JC. Magnetization transfer ratio histogram analysis of gray matter in relapsing-remitting multiple sclerosis. AJNR Am J Neuroradiol 2001;22:470–475
    Abstract/FREE Full Text
  33. ↵
    Alavi A, Newberg AB, Souder E, Berlin JA. Quantitative analysis of PET and MRI data in normal aging and Alzheimer’s disease: atrophy weighted total brain metabolism and absolute whole brain metabolism as reliable discriminators. J Nucl Med 1993;34:1681–1687
  34. ↵
    Lundbom N. Determination of magnetization transfer contrast in tissue: an MR imaging study of brain tumors. AJR Am J Roentgenol 1992;159:1279–1285
    PubMed
  35. ↵
    Ge Y, Grossman RI, Udupa JK, Babb JS, Mannon LJ, McGowan JC. Magnetization transfer ratio histogram analysis of normal-appearing gray matter and normal-appearing white matter in multiple sclerosis. J Comput Assist Tomogr 2002;26:62–68
    CrossRefPubMedWeb of Science
  36. ↵
    Yakovlev PI, Lecours AR. The myelogenetic cycles of regional maturation of the brain. In: Minkrowski A, ed. Regional Development of the Brain in Early Life. Oxford, England: Blackwell;1967 :3–70
  37. ↵
    Courchesne E, Chisum HJ, Townsend J, et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology 2000;216:672–682
    CrossRefPubMedWeb of Science
  38. Breger RK, Yetkin FZ, Fischer ME, Papke RA, Haughton VM, Rimm AA. T1 and T2 in the cerebrum: correlation with age, gender and demographic factors. Radiology 1991;181:545–547
    PubMed
  39. ↵
    Sullivan EV, Adalsteinsson E, Hedehus M, et al. Equivalent disruption of regional white matter microstructure in ageing healthy men and women. Neuroreport 2001;12:99–104
    CrossRefPubMedWeb of Science
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American Journal of Neuroradiology: 23 (8)
American Journal of Neuroradiology
Vol. 23, Issue 8
1 Sep 2002
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Cite this article
Yulin Ge, Robert I. Grossman, James S. Babb, Marcie L. Rabin, Lois J. Mannon, Dennis L. Kolson
Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis
American Journal of Neuroradiology Sep 2002, 23 (8) 1334-1341;

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Age-Related Total Gray Matter and White Matter Changes in Normal Adult Brain. Part II: Quantitative Magnetization Transfer Ratio Histogram Analysis
Yulin Ge, Robert I. Grossman, James S. Babb, Marcie L. Rabin, Lois J. Mannon, Dennis L. Kolson
American Journal of Neuroradiology Sep 2002, 23 (8) 1334-1341;
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