Corpus Callosum Morphology and Microstructure Assessed Using Structural MR Imaging and Diffusion Tensor Imaging: Initial Findings in Adults with Neurofibromatosis Type 1

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Fig 1.
Line diagram of the divisions of the CC used for regional width measurements and factor structure by using the method of Denenberg et al (1991)¹³ and Denenberg et al (1991).¹⁴ See text for details.
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Fig 2.
A, The mean widths (±95% CIs) of the individual factors for both subjects with NF-1 and controls. B, Schematic representation of the regions of the CC that are statistically significantly wider in subjects with NF-1 compared with controls (white indicates not significant; light gray, significant to P < .05; and dark gray, significant to P < .005). C and D, Midsagittal images from the T1-weighted volume dataset from a person with NF-1 (C) and a matched control (D). The CC is visibly larger in the person with NF-1, particularly in the posterior aspect.
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Fig 3.
A and B, Sagittally reformatted color FA maps for a subject with NF-1 (A) and a matched control (B), with color-scale guide below. C and D, Tractography for the subject with NF-1 (C) and the control (D).

Table 1:

Mean (± SD) global and regional CC measures for patients with NF-1 and matched controls^a

a There is no significant difference between the total brain volumes of the subjects with NF-1 and controls, but the area and length of the CC are larger in NF-1. The factor groupings are also presented pictorially in Fig 1.
b P <.05 after the Bonferroni correction.
c P < .05 before the Bonferroni correction (.05/10) only.

Table 2:

Mean (± SD) diffusion measures for subjects with NF-1 and matched controls^a