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Research ArticleSpine

Spine Cryoablation: A Multimodality Image-Guided Approach for Tumors Adjacent to Major Neural Elements

J.P. Guenette, K. Tuncali, N. Himes, S. Tatli and T.C. Lee
American Journal of Neuroradiology December 2016, 37 (12) 2396-2399; DOI: https://doi.org/10.3174/ajnr.A4923
J.P. Guenette
aFrom the Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts.
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K. Tuncali
aFrom the Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts.
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N. Himes
aFrom the Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts.
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S. Tatli
aFrom the Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts.
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T.C. Lee
aFrom the Department of Radiology, Brigham & Women's Hospital, Boston, Massachusetts.
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    Fig 1.

    51-year-old woman with lytic T10 lung adenocarcinoma metastasis. A, Intraprocedural axial prone CT image rotated for visual convenience demonstrates destructive lesion (black arrows) extending to the thecal sac with a cryoprobe within the mass. B, Intraprocedural TSE T2-weighted image in the axial plane demonstrates ice ball (white arrows) covering the lesion with preservation of the thecal sac (black arrows) and aorta (black arrow with white border), and C, sagittal plane demonstrates the ice ball (white arrows) with preservation of the neural foramina (black arrows).

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    Fig 2.

    50-year-old man with PET-avid C2–C3 neural foramen adenoid cystic carcinoma metastasis largely occult on CT. Intraprocedural axial fused PET/CT image demonstrates cryoprobe (white arrows) coursing immediately posterior to the styloid process within FDG-avid lesion at the end of the second freeze; the ice ball was not well visualized. The carotid artery was immediately anterolateral to the styloid process.

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    Table 1:

    Demographics of spine ablations in chronological order

    Patient #Age (yr)SexLocationSize (mm)Pathology
    168ML4 lamina and inferior facet12Presumed DLBCL; mixed chronic inflammation on pathology
    217MC7 pedicle11Osteoid osteoma
    322ML1 pedicle15Osteoblastoma
    466FT4 vertebral body/paraspinous28Leiomyosarcoma metastasis
    550MC2–C3 neural foramen16Adenoid cystic carcinoma metastasis
    217MC7 pedicle (repeat)11Osteoid osteoma
    651FT10 vertebral body31Lung adenocarcinoma metastasis
    754MT12 vertebral body15Atypical spindle cell tumor
    323ML1 pedicle (repeat)15Osteoblastoma
    • Note:—DLBCL indicates diffuse large B-cell lymphoma.

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    Table 2:

    Methods and results of spine ablations in chronological order

    Patient #Guidance ModalityMonitoring ModalityProcedure GoalOutcomes
    1MRIMRIComplete ablationNo increase in size or posterior element destruction on CT 22 months postprocedure
    2CTMRIPain reliefSecond procedure for less severe but residual pain
    3CTMRIPain reliefSecond procedure for less severe but residual pain
    4CTCTComplete ablationSustained resolution of pain 5 months postprocedure; no increase in lesion size on CT 5 months postprocedure
    5PET/CTPET/CTComplete ablationLost to follow-up
    2CTMRIComplete ablationSustained resolution of pain 7 months postprocedure without imaging at the time of writing
    6PET/CTMRIComplete ablationContinued pain postprocedure, with MRI 1 month postprocedure demonstrating likely tumor at the inferior endplate of T9 but complete ablation of the targeted T10 lesion; subsequent systemic chemotherapy and surgery
    7PET/CTMRIComplete ablationSustained resolution of pain and no increase in lesion size 6 months postprocedure
    3CTMRIComplete ablationSustained resolution of pain 4 months postprocedure without imaging at the time of writing
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American Journal of Neuroradiology: 37 (12)
American Journal of Neuroradiology
Vol. 37, Issue 12
1 Dec 2016
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Cite this article
J.P. Guenette, K. Tuncali, N. Himes, S. Tatli, T.C. Lee
Spine Cryoablation: A Multimodality Image-Guided Approach for Tumors Adjacent to Major Neural Elements
American Journal of Neuroradiology Dec 2016, 37 (12) 2396-2399; DOI: 10.3174/ajnr.A4923

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Spine Cryoablation: A Multimodality Image-Guided Approach for Tumors Adjacent to Major Neural Elements
J.P. Guenette, K. Tuncali, N. Himes, S. Tatli, T.C. Lee
American Journal of Neuroradiology Dec 2016, 37 (12) 2396-2399; DOI: 10.3174/ajnr.A4923
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    Journal of Vascular and Interventional Radiology 2019 30 9
  • MRI-guided cryoablation for metastatic spine disease: intermediate-term clinical outcomes in 14 consecutive patients
    Ziev B. Moses, Thomas C. Lee, Kevin T. Huang, Jeffrey P. Guenette, John H. Chi
    Journal of Neurosurgery: Spine 2020 32 5
  • MRI-Guided Cryoablation of Epidural Malignancies in the Spinal Canal Resulting in Neural Decompression and Regrowth of Bone
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    American Journal of Roentgenology 2019 212 1
  • Percutaneous image-guided cryoablation of spinal metastases: A systematic review
    Navraj S. Sagoo, Ali S. Haider, Ahmad Ozair, Christopher Vannabouathong, Masum Rahman, Maryam Haider, Neha Sharma, Karuna M. Raj, Sean D. Raj, Justin C. Paul, Michael P. Steinmetz, Owoicho Adogwa, Salah G. Aoun, Peter G. Passias, Shaleen Vira
    Journal of Clinical Neuroscience 2022 96
  • Introduction to Neuroimaging
    Elizabeth George, Jeffrey P. Guenette, Thomas C. Lee
    The American Journal of Medicine 2018 131 4
  • CT-Guided Percutaneous Spine Biopsy Specimen Adequacy, Pathology Concordance, and Negative Predictive Value with Battery-Powered Drill and Manual Approaches
    Jeffrey P. Guenette, Charles H. Cho, Raymond Y. Huang, Nityanand Miskin, Varand Ghazikhanian, Thomas C. Lee
    Current Problems in Diagnostic Radiology 2019 48 6
  • MRI and CT Guided Cryoablation for Intracranial Extension of Malignancies along the Trigeminal Nerve
    Thomas C. Lee, Jeffrey P. Guenette, Ziev B. Moses, Jong Woo Lee, Donald J. Annino, John H. Chi
    Journal of Neurological Surgery Part B: Skull Base 2020 81 05
  • Intraprocedural MRI monitoring during percutaneous cryoablation procedures of the head and neck, and spine: a single institution experience
    Peter M. Schaefer, Jeffrey P. Guenette, Thomas C. Lee
    Clinical Imaging 2021 73
  • Practical Approach to the Neurological Patient
    Thomas C. Lee, Andrew G. Schneider
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