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Research ArticleINTERVENTIONAL

Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment?

M.N. Rozenfeld, S.A. Ansari, P. Mohan, A. Shaibani, E.J. Russell and M.C. Hurley
American Journal of Neuroradiology February 2016, 37 (2) 290-293; DOI: https://doi.org/10.3174/ajnr.A4490
M.N. Rozenfeld
aFrom the Department of Radiology (M.N.R.), University of Chicago Medical Center, Chicago, Illinois
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S.A. Ansari
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois
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P. Mohan
cDepartment of Radiology (P.M.), University of Miami, Miami, Florida.
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A. Shaibani
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois
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E.J. Russell
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois
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M.C. Hurley
bDepartment of Radiology (S.A.A., A.S., E.J.R., M.C.H.), Northwestern University Feinberg School of Medicine, Chicago, Illinois
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    Table 1:

    Primary end points

    ADPCKDControlsP Value
    In-hospital mortality
        Coiling0.0%0.3%NS
        Clipping0.0%0.5%NS
    Mean length of stay (days)
        Coiling2.572.99NS
        Clipping5.726.91<.01
    Mean total hospital charges
        Coiling$61,874$85,568<.01
        Clipping$67,133$89,787<.01
    • Note:—NS indicates not significant.

    • View popup
    Table 2:

    Secondary end points

    ADPCKDControlsP Value
    Iatrogenic cerebrovascular hemorrhage or infarction
        Coiling5 (9.4%)55 (3.0%)<.01
        Clipping16 (11.8%)109 (6.4%)<.02
    Intracerebral hemorrhage
        Coiling0 (0%)11 (0.6%)NS
        Clipping0 (0%)39 (2.3%)NS
    Unspecified intracranial hemorrhage
        Coiling0 (0%)0 (0%)NS
        Clipping0 (0%)0 (0%)NS
    Cerebral embolism with cerebral infarction
        Coiling5 (9.4%)14 (0.8%).00
        Clipping0 (0%)5 (0.3%)NS
    Dissection of carotid artery
        Coiling5 (9.4%)0 (0%).00
        Clipping0 (0.0%)0 (0%)NS
    Dissection of vertebral artery
        Coiling0 (0%)0 (0%)NS
        Clipping0 (0%)0 (0%)NS
    • Note:—NS indicates not significant.

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American Journal of Neuroradiology: 37 (2)
American Journal of Neuroradiology
Vol. 37, Issue 2
1 Feb 2016
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Cite this article
M.N. Rozenfeld, S.A. Ansari, P. Mohan, A. Shaibani, E.J. Russell, M.C. Hurley
Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment?
American Journal of Neuroradiology Feb 2016, 37 (2) 290-293; DOI: 10.3174/ajnr.A4490

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Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment?
M.N. Rozenfeld, S.A. Ansari, P. Mohan, A. Shaibani, E.J. Russell, M.C. Hurley
American Journal of Neuroradiology Feb 2016, 37 (2) 290-293; DOI: 10.3174/ajnr.A4490
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    American Journal of Neuroradiology 2016 37 9
  • MR Angiography Screening and Surveillance for Intracranial Aneurysms in Autosomal Dominant Polycystic Kidney Disease: A Cost-effectiveness Analysis
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    Ao Li, Song Fan, Yuchen Xu, Jialin Meng, Xufeng Shen, Jun Mao, Li Zhang, Xiansheng Zhang, Gilbert Moeckel, Dianqing Wu, Guanqing Wu, Chaozhao Liang
    Journal of Cellular and Molecular Medicine 2017 21 8
  • Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD
    Ao Li, Yuchen Xu, Song Fan, Jialin Meng, Xufeng Shen, Qian Xiao, Yuan Li, Li Zhang, Xiansheng Zhang, Guanqing Wu, Chaozhao Liang, Dianqing Wu
    JCI Insight 2018 3 5

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