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Research ArticleINTERVENTIONAL

Prediction of Stent-Retriever Thrombectomy Outcomes by Dynamic Multidetector CT Angiography in Patients with Acute Carotid T or MCA Occlusions

K.M. Thierfelder, W.H. Sommer, B. Ertl-Wagner, S.E. Beyer, F.G. Meinel, W.G. Kunz, G. Buchholz, M.F. Reiser and H. Janssen
American Journal of Neuroradiology July 2016, 37 (7) 1296-1302; DOI: https://doi.org/10.3174/ajnr.A4694
K.M. Thierfelder
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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W.H. Sommer
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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B. Ertl-Wagner
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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S.E. Beyer
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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F.G. Meinel
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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W.G. Kunz
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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G. Buchholz
bDepartment of Neurology (G.B.)
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M.F. Reiser
aFrom the Institute for Clinical Radiology (K.M.T., W.H.S., B.E.-W., S.E.B., F.G.M., W.G.K., M.F.R.)
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H. Janssen
cDepartment of Neuroradiology (H.J.), Ludwig-Maximilian University Hospital, Munich, Germany.
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Article Figures & Data

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  • Fig 1.
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    Fig 1.

    Occlusion-length measurement. Temporal MIP images show the occluding thrombus as a filling defect. A, Axial temporal MIP image of a left-sided carotid T occlusion. B and C, Axial and sagittal images of a right-sided M1 occlusion.

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    Fig 2.

    Flow chart of patient selection. dynCTA indicates dynamic CT angiography.

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    Fig 3.

    Correlation between dynamic CTA predictors and angiographic outcome. Shorter occlusion length (A) is associated with favorable technical thrombectomy outcome. Both collateralization grade (B) and time delay (C) do not show a significant correlation with angiographic thrombectomy outcome.

Tables

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    Table 1:

    Characteristics of patients with favorable (mTICI = 3) and nonfavorable (mTICI < 3) recanalization outcomea

    Overall (N = 69)mTICI = 3 (n = 31)mTICI < 3 (n = 38)Odds RatioP Value
    Age (yr)68.4 ± 14.466.7 ± 14.169.8 ± 14.51.000.981
    Male sex (No.)32 (46%)15 (48%)17 (45%)1.152.775
    Additional ICA occlusion (No.)22 (32%)9 (29%)13 (34%)0.708.485
    Carotid T occlusion (No.)19 (28%)5 (16%)14 (37%)1.768.274
    Time to recanalization (min)119 ± 82108 ± 69127 ± 920.859.389
    IVT (No.)54 (78%)24 (77%)30 (79%)1.094.878
    Occlusion length (mm)15.6 ± 7.912.9 ± 6.817.7 ± 8.10.409.018b
    Collateralization grade (0–20)13.8 ± 4.313.7 ± 4.513.7 ± 4.11.003.958
    Time delay (sec)6.5 ± 2.86.2 ± 2.16.7 ± 3.20.896.251
    • ↵a The last 2 columns show the results of the univariate logistic regression analysis to determine the effect of predictors on recanalization success (N = 69).

    • ↵b Statistically significant.

    • View popup
    Table 2:

    Characteristics of patients with favorable (mRSdisc ≤ 2) and nonfavorable (mRSdisc > 2) clinical outcomea

    Overall (N = 69)mRSdisc ≤ 2 (n = 17)mRSdisc > 2 (n = 52)Odds RatioP Value
    Age (yr)68.4 ± 14.465.4 ± 16.569.4 ± 13.80.982.380
    Male sex (No.)32 (46%)7 (41%)25 (48%)0.877.839
    Additional ICA occlusion (No.)22 (32%)4 (23%)18 (35%)0.960.949
    Carotid T occlusion (No.)19 (28%)6 (35%)13 (25%)1.023.974
    Time to recanalization (min)119 ± 82101 ± 77126 ± 860.694.181b
    IVT (No.)54 (78%)15 (88%)39 (75%)0.202.142b
    Occlusion length (mm)15.6 ± 7.913.6 ± 7.416.1 ± 8.20.664.330
    Collateralization grade (0–20)13.8 ± 4.313.9 ± 4.513.8 ± 4.20.996.953
    Time delay (sec)6.5 ± 2.86.7 ± 3.26.4 ± 2.81.011.917
    • Note:—mRSdisc indicates mRS at discharge.

    • ↵a The last 2 columns show the results of the univariate logistic regression analysis to determine the effect of predictors on clinical outcome (N = 69).

    • ↵b Below < .2 and therefore included in multivariate analysis.

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American Journal of Neuroradiology: 37 (7)
American Journal of Neuroradiology
Vol. 37, Issue 7
1 Jul 2016
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K.M. Thierfelder, W.H. Sommer, B. Ertl-Wagner, S.E. Beyer, F.G. Meinel, W.G. Kunz, G. Buchholz, M.F. Reiser, H. Janssen
Prediction of Stent-Retriever Thrombectomy Outcomes by Dynamic Multidetector CT Angiography in Patients with Acute Carotid T or MCA Occlusions
American Journal of Neuroradiology Jul 2016, 37 (7) 1296-1302; DOI: 10.3174/ajnr.A4694

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Prediction of Stent-Retriever Thrombectomy Outcomes by Dynamic Multidetector CT Angiography in Patients with Acute Carotid T or MCA Occlusions
K.M. Thierfelder, W.H. Sommer, B. Ertl-Wagner, S.E. Beyer, F.G. Meinel, W.G. Kunz, G. Buchholz, M.F. Reiser, H. Janssen
American Journal of Neuroradiology Jul 2016, 37 (7) 1296-1302; DOI: 10.3174/ajnr.A4694
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