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The most recent 2016 WHO classification includes MVNT as a unique cytoarchitectural pattern of gangliocytoma, though it remains unclear whether MVNT is a true neoplastic process or a dysplastic hamartomatous/malformative lesion. The authors report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions. They conclude that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm.

Fifty-eight patients with pathologically confirmed gliomas underwent preoperative 3D pseudocontinuous arterial spin-labeling and ROC curves were generated for parameters to distinguish high-grade from low-grade gliomas. Both maximum CBF and maximum relative CBF were significantly higher in high-grade than in low-grade gliomas. After adjustment for age, a higher maximum CBF and higher maximum relative CBF were associated with worse progression-free survival.