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Research ArticleFunctional

Corticopallidal Connectome of the Globus Pallidus Externus in Humans: An Exploratory Study of Structural Connectivity Using Probabilistic Diffusion Tractography

S.S. Grewal, V.M. Holanda and E.H. Middlebrooks
American Journal of Neuroradiology November 2018, 39 (11) 2120-2125; DOI: https://doi.org/10.3174/ajnr.A5816
S.S. Grewal
aFrom the Departments of Neurosurgery (S.S.G., E.H.M.)
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V.M. Holanda
cCenter of Neurology and Neurosurgery Associates (V.M.H.), BP-A Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
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E.H. Middlebrooks
aFrom the Departments of Neurosurgery (S.S.G., E.H.M.)
bRadiology (E.H.M.), Mayo Clinic, Jacksonville, Florida
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    FIGURE.

    Connectogram showing the connectivity profile for the right and left globus pallidus externus. Lines are weighted by tract count.

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  • Cortical ROIs meeting the tract threshold for connectivity to the globus pallidus externus for both hemispheresc

    Cortical RegionRight Hemisphere (% Tract Probability) (SD)Left Hemisphere (% Tract Probability) (SD)P Value
    Frontal pole14.4% (9.4%)7.7% (5.4%).004
    Insula11.0% (4.2%)8.5% (4.6%).1
    Temporal pole9.2% (7.7%)10.5% (8.0%).49
    Medial orbitofrontal6.7% (5.9%)8.3% (4.9%).21
    Entorhinal5.1% (4.4%)7.4% (6.6%).22
    Superior frontal4.3% (3.5%)4.8% (3.2%).56
    Pars orbitalis3.8% (2.6%)3.2% (2.6%).4
    Lateral orbitofrontal3.8% (3.9%)4.1% (3.9%).72
    Paracentral3.4% (2.9%)3.9% (2.9%).5
    Postcentral3.2% (2.2%)4.3% (2.2%).1
    Pars triangularis3.1% (4.1%)3.2% (3.7%).96
    Precentral2.9% (1.9%)4.4% (2.5%).07
    Rostral anterior cingulate2.7% (2.8%)1.2% (1.2%).06
    Superior parietal2.3% (1.3%)2.9% (1.2%).1
    Rostral middle frontal2.3% (1.4%)2.0% (1.2%).83
    Isthmus cingulate2.2% (1.2%)3.5% (3.2%).27
    Parahippocampal1.4% (1.2%)2.1% (1.5%).12
    • a The P value is reported for left-to-right tract comparison.

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American Journal of Neuroradiology: 39 (11)
American Journal of Neuroradiology
Vol. 39, Issue 11
1 Nov 2018
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Cite this article
S.S. Grewal, V.M. Holanda, E.H. Middlebrooks
Corticopallidal Connectome of the Globus Pallidus Externus in Humans: An Exploratory Study of Structural Connectivity Using Probabilistic Diffusion Tractography
American Journal of Neuroradiology Nov 2018, 39 (11) 2120-2125; DOI: 10.3174/ajnr.A5816

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Corticopallidal Connectome of the Globus Pallidus Externus in Humans: An Exploratory Study of Structural Connectivity Using Probabilistic Diffusion Tractography
S.S. Grewal, V.M. Holanda, E.H. Middlebrooks
American Journal of Neuroradiology Nov 2018, 39 (11) 2120-2125; DOI: 10.3174/ajnr.A5816
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