Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T

^aFrom the UCLA Brain Tumor Imaging Laboratory (Y.-L.W., J.Y., A.C., C.R., B.M.E.)
^bCenter for Computer Vision and Imaging Biomarkers, Department of Radiological Sciences (J.Y., A.C., C.R., N.S., W.B.P., B.M.E.)
^cPhysics and Biology in Medicine (B.M.E.)
^dDepartment of Neurology (P.L.N., A.L., N.N., M.J., T.F.C.)
^eDepartment of Psychiatry and Biobehavioral Sciences (B.M.E.)
^fUCLA Brain Research Institute (L.M.L., A.L., B.M.E.)
^gDepartment of Neurosurgery (L.M.L.), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California
^hDepartment of Radiology (Y.-L.W.), People's Liberation Army General Hospital, Beijing, China
ⁱDepartment of Bioengineering (J.Y., B.M.E.), Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, California.

Please address correspondence to Benjamin M. Ellingson, PhD, Departments of Radiological Sciences and Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, 924 Westwood Blvd., Suite 615, Los Angeles, CA 90024; e-mail: bellingson{at}mednet.ucla.edu