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Research ArticleADULT BRAIN

Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling

J. Narvid, D. McCoy, S.M. Dupont, A. Callen, D. Tosun, J. Hellmuth and V. Valcour
American Journal of Neuroradiology November 2018, DOI: https://doi.org/10.3174/ajnr.A5902
J. Narvid
aFrom the Departments of Radiology and Biomedical Imaging (J.N., D.M., S.M.D., A.C., D.T.)
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D. McCoy
aFrom the Departments of Radiology and Biomedical Imaging (J.N., D.M., S.M.D., A.C., D.T.)
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S.M. Dupont
aFrom the Departments of Radiology and Biomedical Imaging (J.N., D.M., S.M.D., A.C., D.T.)
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A. Callen
aFrom the Departments of Radiology and Biomedical Imaging (J.N., D.M., S.M.D., A.C., D.T.)
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D. Tosun
aFrom the Departments of Radiology and Biomedical Imaging (J.N., D.M., S.M.D., A.C., D.T.)
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J. Hellmuth
bNeurology (J.H., V.V.), University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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V. Valcour
bNeurology (J.H., V.V.), University of California at San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California.
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References

  1. 1.↵
    1. Hood JE,
    2. Golden MR,
    3. Hughes JP, et al
    . Projected demographic composition of the United States population of people living with diagnosed HIV. AIDS Care 2017;29:1543–50 doi:10.1080/09540121.2017.1308466 pmid:28395528
    CrossRefPubMed
  2. 2.↵
    1. Heaton RK,
    2. Clifford DB,
    3. Franklin DR Jr., et al
    ; CHARTER Group. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study. Neurology 2010;75:2087–96 doi:10.1212/WNL.0b013e318200d727 pmid:21135382
    Abstract/FREE Full Text
  3. 3.↵
    1. Hasse B,
    2. Ledergerber B,
    3. Furrer H, et al
    ; Swiss HIV Cohort Study. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2011;53:1130–39 doi:10.1093/cid/cir626 pmid:21998280
    CrossRefPubMed
  4. 4.↵
    1. Chow FC
    . HIV infection, vascular disease, and stroke. Semin Neurol 2014;34:35–46 doi:10.1055/s-0034-1372341 pmid:24715487
    CrossRefPubMed
  5. 5.↵
    1. Hsue PY,
    2. Deeks SG,
    3. Hunt PW
    . Immunologic basis of cardiovascular disease in HIV-infected adults. J Infect Dis 2012;205(Suppl 3):S375–82 doi:10.1093/infdis/jis200 pmid:22577211
    CrossRefPubMed
  6. 6.↵
    1. Silva JN,
    2. Polesskaya O,
    3. Wei HS, et al
    . Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation 2014;21:664–76 doi:10.1111/micc.12145 pmid:24813724
    CrossRefPubMed
  7. 7.↵
    1. Jia P,
    2. Zhao Z,
    3. Hulgan T, et al
    ; CHARTER Study Group. Genome-wide association study of HIV-associated neurocognitive disorder (HAND): a CHARTER group study. Am J Med Genet B Neuropsychiatr Genet 2017;174:413–26 doi:10.1002/ajmg.b.32530 pmid:28447399
    CrossRefPubMed
  8. 8.↵
    1. Gelman BB,
    2. Chen T,
    3. Lisinicchia JG, et al
    ; National NeuroAIDS Tissue Consortium. The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment. PLoS One 2012;7:e46178 doi:10.1371/journal.pone.0046178 pmid:23049970
    CrossRefPubMed
  9. 9.↵
    1. Gelman BB
    . Neuropathology of HAND with suppressive antiretroviral therapy: encephalitis and neurodegeneration reconsidered. Curr HIV/AIDS Rep 2015;12:272–79 doi:10.1007/s11904-015-0266-8 pmid:25860316
    CrossRefPubMed
  10. 10.↵
    1. Nakamoto BK,
    2. Jahanshad N,
    3. McMurtray A, et al
    . Cerebrovascular risk factors and brain microstructural abnormalities on diffusion tensor images in HIV-infected individuals. J Neurovirol 2012;18:303–12 doi:10.1007/s13365-012-0106-1 pmid:22585287
    CrossRefPubMed
  11. 11.↵
    1. Watson C,
    2. Busovaca E,
    3. Foley JM, et al
    . White matter hyperintensities correlate to cognition and fiber tract integrity in older adults with HIV. J Neurovirol 2017;23:422–29 doi:10.1007/s13365-016-0509-5 pmid:28101804
    CrossRefPubMed
  12. 12.↵
    1. Su T,
    2. Wit FW,
    3. Caan MW, et al
    ; AGEhIV Cohort Study. White matter hyperintensities in relation to cognition in HIV-infected men with sustained suppressed viral load on combination antiretroviral therapy. AIDS 2016;30:2329–39 doi:10.1097/QAD.0000000000001133 pmid:27149087
    CrossRefPubMed
  13. 13.↵
    1. Chow FC,
    2. Boscardin WJ,
    3. Mills C, et al
    . Cerebral vasoreactivity is impaired in treated, virally suppressed HIV-infected individuals. AIDS 2016;30:45–55 doi:10.1097/QAD.0000000000000875 pmid:26372478
    CrossRefPubMed
  14. 14.↵
    1. Chow FC,
    2. Li Y,
    3. Hu Y, et al
    . Relationship between HIV infection, antiretroviral therapy, inflammatory markers, and cerebrovascular endothelial function among adults in urban China. J Acquir Immune Defic Syndr 2017;74:339–46 doi:10.1097/QAI.0000000000001254 pmid:27875362
    CrossRefPubMed
  15. 15.↵
    1. van der Veen PH,
    2. Muller M,
    3. Vincken KL, et al
    ; SMART Study Group. Longitudinal relationship between cerebral small-vessel disease and cerebral blood flow: the second manifestations of arterial disease-magnetic resonance study. Stroke 2015;46:1233–38 doi:10.1161/STROKEAHA.114.008030 pmid:25804924
    Abstract/FREE Full Text
  16. 16.↵
    1. Mattsson N,
    2. Tosun D,
    3. Insel PS, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Association of brain amyloid-β with cerebral perfusion and structure in Alzheimer's disease and mild cognitive impairment. Brain 2014;137:1550–61 doi:10.1093/brain/awu043 pmid:24625697
    CrossRefPubMed
  17. 17.↵
    1. Tosun D,
    2. Schuff N,
    3. Jagust W, et al
    ; Alzheimer's Disease Neuroimaging Initiative. Discriminative power of arterial spin labeling magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography changes for amyloid-β-positive subjects in the Alzheimer's disease continuum. Neurodegener Dis 2016;16:87–94 doi:10.1159/000439257 pmid:26560336
    CrossRefPubMed
  18. 18.↵
    1. Ances BM,
    2. Sisti D,
    3. Vaida F, et al
    ; HNRC group. Resting cerebral blood flow: a potential biomarker of the effects of HIV in the brain. Neurology 2009;73:702–08 doi:10.1212/WNL.0b013e3181b59a97 pmid:19720977
    Abstract/FREE Full Text
  19. 19.↵
    1. Su T,
    2. Mutsaerts HJ,
    3. Caan MW, et al
    ; AGEhIV Cohort Study. Cerebral blood flow and cognitive function in HIV-infected men with sustained suppressed viremia on combination antiretroviral therapy. AIDS 2017;31:847–56 doi:10.1097/QAD.0000000000001414 pmid:28121708
    CrossRefPubMed
  20. 20.↵
    1. Towgood KJ,
    2. Pitkanen M,
    3. Kulasegaram R, et al
    . Regional cerebral blood flow and FDG uptake in asymptomatic HIV-1 men. Hum Brain Mapp 2013;34:2484–93 doi:10.1002/hbm.22078 pmid:22496057
    CrossRefPubMed
  21. 21.↵
    1. Sen S,
    2. An H,
    3. Menezes P, et al
    . Increased cortical cerebral blood flow in asymptomatic human immunodeficiency virus-infected subjects. J Stroke Cerebrovasc Dis 2016;25:1891–95 doi:10.1016/j.jstrokecerebrovasdis.2016.03.045 pmid:27160382
    CrossRefPubMed
  22. 22.↵
    1. Clifford KM,
    2. Samboju V,
    3. Cobigo Y, et al
    . Progressive brain atrophy despite persistent viral suppression in HIV patients older than 60 years. J Acquir Immune Defic Syndr 2017;76:289–97 doi:10.1097/QAI.0000000000001489 pmid:28650401
    CrossRefPubMed
  23. 23.↵
    1. Antinori A,
    2. Arendt G,
    3. Becker JT, et al
    . Updated research nosology for HIV-associated neurocognitive disorders. Neurology 2007;69:1789–99 doi:10.1212/01.WNL.0000287431.88658.8b pmid:17914061
    Abstract/FREE Full Text
  24. 24.↵
    1. Milanini B,
    2. Valcour V
    . Differentiating HIV-associated neurocognitive disorders from Alzheimer's disease: an emerging issue in geriatric NeuroHIV. Curr HIV/AIDS Rep 2017;14:123–32 doi:10.1007/s11904-017-0361-0 pmid:28779301
    CrossRefPubMed
  25. 25.↵
    1. Luh WM,
    2. Wong EC,
    3. Bandettini PA, et al
    . QUIPSS II with thin-slice TI1 periodic saturation: a method for improving accuracy of quantitative perfusion imaging using pulsed arterial spin labeling. Magn Reson Med 1999;41:1246–54 pmid:10371458
    CrossRefPubMedWeb of Science
  26. 26.↵
    1. Tao R,
    2. Fletcher PT,
    3. Gerber S, et al
    . A variational image-based approach to the correction of susceptibility artifacts in the alignment of diffusion weighted and structural MRI. Inf Process Med Imaging 2009;21:664–75 pmid:19694302
    PubMed
  27. 27.↵
    R Development Core Team. R foundation for statistical computing. https://www.r-project.org/.
  28. 28.↵
    1. Friedman J,
    2. Hastie T,
    3. Tibshirani R
    . Regularization paths for generalized linear models via coordinate descent. J Stat Softw 2010;33;1–22 pmid:20808728
    CrossRefPubMedWeb of Science
  29. 29.↵
    1. van Buuren S,
    2. Groothuis-Oudshoorn K
    . MICE: multivariate imputation by chained equations in R. J Stat Softw 2011;45. https://www.jstatsoft.org/article/view/v045i03.
  30. 30.↵
    1. Frigessi A,
    2. Bühlmann P,
    3. Glad IK, et al
    . Statistical Analysis for High-Dimensional Data: The Abel Symposium 2014. New York: Springer; 2016
  31. 31.↵
    1. Sanford R,
    2. Fernandez Cruz AL,
    3. Scott SC, et al
    . Regionally specific brain volumetric and cortical thickness changes in HIV-infected patients in the HAART era. J Acquir Immune Defic Syndr 2017;74:563–70 doi:10.1097/QAI.0000000000001294 pmid:28129254
    CrossRefPubMed
  32. 32.↵
    1. Kendall CE,
    2. Wong J,
    3. Taljaard M, et al
    . A cross-sectional, population-based study measuring comorbidity among people living with HIV in Ontario. BMC Public Health 2014;14:161 doi:10.1186/1471-2458-14-161 pmid:24524286
    CrossRefPubMed
  33. 33.↵
    1. Sheppard DP,
    2. Iudicello JE,
    3. Bondi MW, et al
    . Elevated rates of mild cognitive impairment in HIV disease. J Neurovirol 2015;21:576–84 doi:10.1007/s13365-015-0366-7 pmid:26139019
    CrossRefPubMed
  34. 34.↵
    1. Hong S,
    2. Banks WA
    . Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications. Brain Behav Immun 2015;45;1–12 doi:10.1016/j.bbi.2014.10.008 pmid:25449672
    CrossRefPubMed
  35. 35.↵
    1. Chow FC,
    2. Regan S,
    3. Zanni MV, et al
    . Elevated ischemic stroke risk among women living with HIV infection. AIDS 2018;32:59–67 doi:10.1097/QAD.0000000000001650 pmid:28926405
    CrossRefPubMed
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J. Narvid, D. McCoy, S.M. Dupont, A. Callen, D. Tosun, J. Hellmuth, V. Valcour
Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling
American Journal of Neuroradiology Nov 2018, DOI: 10.3174/ajnr.A5902

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Abnormal Cerebral Perfusion Profile in Older Adults with HIV-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin-Labeling
J. Narvid, D. McCoy, S.M. Dupont, A. Callen, D. Tosun, J. Hellmuth, V. Valcour
American Journal of Neuroradiology Nov 2018, DOI: 10.3174/ajnr.A5902
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