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Research ArticleADULT BRAIN

Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling

K.P.A. Baas, J. Petr, J.P.A. Kuijer, A.J. Nederveen, H.J.M.M. Mutsaerts and K.C.C. van de Ven
American Journal of Neuroradiology November 2020, DOI: https://doi.org/10.3174/ajnr.A6856
K.P.A. Baas
aFrom the Department of Radiology and Nuclear Medicine (K.P.A.B., A.J.N.), Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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J. Petr
bInstitute of Radiopharmaceutical Cancer Research (J.P.), Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany
cDepartment of Biomedical Engineering (J.P., H.J.M.M.M.), Institute Hall, Rochester Institute of Technology, Rochester, New York
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J.P.A. Kuijer
dDepartment of Radiology and Nuclear Medicine (J.P.A.K., H.J.M.M.M.), Amsterdam University Medical Center, VU University Medical Center, Amsterdam, the Netherlands
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A.J. Nederveen
aFrom the Department of Radiology and Nuclear Medicine (K.P.A.B., A.J.N.), Amsterdam University Medical Center, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
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H.J.M.M. Mutsaerts
cDepartment of Biomedical Engineering (J.P., H.J.M.M.M.), Institute Hall, Rochester Institute of Technology, Rochester, New York
dDepartment of Radiology and Nuclear Medicine (J.P.A.K., H.J.M.M.M.), Amsterdam University Medical Center, VU University Medical Center, Amsterdam, the Netherlands
eDepartment of Radiology and Nuclear Medicine (H.J.M.M.M.), University Hospital Ghent, Ghent, Belgium
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K.C.C. van de Ven
fBIU MR (K.C.C.v.d.V.), Philips Healthcare, Best, the Netherlands
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  • FIG 1.
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    FIG 1.

    Bland-Altman plots showing agreement on GM CBF between intra- (upper row) and intersession (lower row) repeated 3D 1800 ms (left column) and 2D 1800 ms (right column) pCASL scans. The asterisk indicates values significantly different from zero (P < .05).

  • FIG 2.
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    FIG 2.

    Three axial slices from group-averaged CBF maps of all pCASL acquisitions at both field strengths. Average age of participants scanned at 1.5T and 3T was 62 ± 12 years and 56 ± 20 years, respectively. HR indicates high resolution.

  • FIG 3.
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    FIG 3.

    Boxplots showing WB and GM CBF without PVC and GM with PVC per PLD and field strength. One, two, and three asterisks indicate P values < .05, .01, and .001, respectively.

  • FIG 4.
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    FIG 4.

    Boxplots showing WB and GM CBF without PVC and GM with PVC, per readout and field strength. One, two, and three asterisks indicate P values < .05, .01, and .001, respectively. HR indicates high resolution.

  • FIG 5.
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    FIG 5.

    Boxplots showing GM spatial CoV per scan type and field strength. Three asterisks indicate P values < .001. HR indicates high resolution.

Tables

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    Table 1:

    Bias in GM spatial CoV between intra- and intersession repeated 3D and 2D acquisitionsa

    GM Spatial CoV
    3D2D
    Intrasession–0.001 (–0.044, 0.042)–0.004 (–0.044, 0.035)
    Intersession–0.004 (–0.085, 0.078)–0.002 (–0.125, 0.120)
    • ↵a Numbers in parentheses are 95% limits of agreement.

    • View popup
    Table 2:

    Spearman’s ρ and corresponding P values between age and ΔCBF and between age and Δspatial CoV from 3D and 2D ASL scans

    3D2D
    Spearman’s ρP ValueSpearman’s ρP Value
    ΔCBF
     Intrasession–0.18.31–0.17.34
     Intersession0.05.800.05.78
    Δspatial CoV
     Intrasession0.07.710.04.82
     Intersession0.15.390.20.26
    • View popup
    Table 3:

    Intra- and intersession wsCV of GM CBF and GM spatial CoV from 3D 1800 ms and 2D 1800 ms scans

    GM CBFGM Spatial CoV
    3D2D3D2D
    Intrasession
     1.5T (n = 14)4.4%4.0%7.6%4.5%
     3T (n = 20)4.7%6.7%5.1%4.3%
    Intersession
     1.5T–1.5T (n = 6)13.5%11.7%6.9%8.4%
     1.5T–3T (n = 14)10.0%14.8%15.5%19.1%
     3T–3T (n = 14)6.8%6.6%11.1%7.6%
    • View popup
    Table 4:

    Pair-wise differences (mean ± SD) between observed GM CBF (mL/100g/min), without PVC, from different pCASL acquisitions

    3D 1800 ms2D 1800 ms3D 1600 ms3D 2000 ms3D 1800 ms HR
    3T
     3D 1800 ms–0.46 ± 1.88a–6.14 ± 1.45b–2.10 ± 3.20bc2.21 ± 1.85b–3.65 ± 2.00b
     2D 1800 ms–0.65 ± 3.13a4.04 ± 2.95bc8.35 ± 2.12b2.49 ± 2.02b
    1.5T
     3D 1800 ms0.15 ± 1.77a–11.03 ± 3.21bc–3.78 ± 2.30b2.83 ± 2.06b
     2D 1800 ms1.15 ± 2.04a7.25 ± 4.05bc13.86 ± 3.95bc
    • Note:—HR indicates high-resolution.

    • ↵a Differences between repeated identical pCASL acquisitions with consensus paper parameter settings.

    • ↵b A bias that is significantly different from zero (P < .05).

    • ↵c A significantly different variance across the observed pair-wise differences between acquisitions compared with the variance across the pair-wise differences between repeated consensus paper parameter settings (P < .05).

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K.P.A. Baas, J. Petr, J.P.A. Kuijer, A.J. Nederveen, H.J.M.M. Mutsaerts, K.C.C. van de Ven
Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
American Journal of Neuroradiology Nov 2020, DOI: 10.3174/ajnr.A6856

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Effects of Acquisition Parameter Modifications and Field Strength on the Reproducibility of Brain Perfusion Measurements Using Arterial Spin-Labeling
K.P.A. Baas, J. Petr, J.P.A. Kuijer, A.J. Nederveen, H.J.M.M. Mutsaerts, K.C.C. van de Ven
American Journal of Neuroradiology Nov 2020, DOI: 10.3174/ajnr.A6856
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