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Research ArticleADULT BRAIN
Open Access

Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings

N. Parsons, A. Outsikas, A. Parish, R. Clohesy, F. D’Aprano, F. Toomey, S. Advani and G.R. Poudel
American Journal of Neuroradiology April 2021, DOI: https://doi.org/10.3174/ajnr.A7113
N. Parsons
aFrom the Cognitive Neuroscience Unit (N.P.)
bSchool of Psychology (N.P., A.O., A.P., R.C.)
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A. Outsikas
bSchool of Psychology (N.P., A.O., A.P., R.C.)
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A. Parish
bSchool of Psychology (N.P., A.O., A.P., R.C.)
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R. Clohesy
bSchool of Psychology (N.P., A.O., A.P., R.C.)
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F. D’Aprano
dMelbourne School of Psychological Sciences (F.D.), The University of Melbourne, Melbourne, Australia
eDepartment of Neurology (F.D.), Royal Melbourne Hospital, Melbourne, Australia
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F. Toomey
cSchool of Medicine (F.T.), Deakin University, Geelong, Australia
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S. Advani
fSocial Behavioural Research Branch (S.A.), National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland
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G.R. Poudel
gDepartment of Health Sciences (G.R.P.), Mary Mackillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
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    FIG 1.

    Visualization of the spatial distribution of neurologic events and network diffusion modeling. (A) The highest proportions of events occur in white matter areas such as the corticospinal tract. (B) In gray matter, the most affected regions are the bilateral superior temporal cortices, precentral cortices, and pallidum. (C) A network diffusion model using structural connectivity edge weights successfully predicts the spread of neurologic events. (C) The epicenters of spread that showed the most significant association between predicted and measured distribution of events are the bilateral cerebellum and putamen. CC indicates corpus callosum.

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N. Parsons, A. Outsikas, A. Parish, R. Clohesy, F. D’Aprano, F. Toomey, S. Advani, G.R. Poudel
Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7113

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Modelling the Anatomic Distribution of Neurologic Events in Patients with COVID-19: A Systematic Review of MRI Findings
N. Parsons, A. Outsikas, A. Parish, R. Clohesy, F. D’Aprano, F. Toomey, S. Advani, G.R. Poudel
American Journal of Neuroradiology Apr 2021, DOI: 10.3174/ajnr.A7113
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