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The authors evaluated 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls who underwent 3T MR imaging with a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility maps they measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both cerebral hemispheres. Susceptibility in the middle part, the posterior part, and the whole substantia nigra was significantly higher in the more and the less affected hemibrains of patients with Parkinson disease than in the healthy controls. Also, susceptibility was significantly higher in the posterior substantia nigra of the more affected hemibrain.