Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation

Y. Zhang; S.A. Gauthier; A. Gupta; W. Chen; J. Comunale; G.C.-Y. Chiang; D. Zhou; G. Askin; W. Zhu; D. Pitt; Y. Wang

doi:10.3174/ajnr.A4825

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Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation

Y. Zhang, S.A. Gauthier, A. Gupta, W. Chen, J. Comunale, G.C.-Y. Chiang, D. Zhou, G. Askin, W. Zhu, D. Pitt and Y. Wang

American Journal of Neuroradiology September 2016, 37 (9) 1629-1635; DOI: https://doi.org/10.3174/ajnr.A4825

Y. Zhang

aFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

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S.A. Gauthier

cNeurology (S.A.G.)

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A. Gupta

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

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W. Chen

aFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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J. Comunale

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

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G.C.-Y. Chiang

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

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D. Zhou

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

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G. Askin

dHealthcare Policy and Research (G.A.), Weill Cornell Medical College, New York, New York

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W. Zhu

aFrom the Department of Radiology (Y.Z., W.C., W.Z.), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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D. Pitt

eDepartment of Neurology (D.P.), School of Medicine, Yale University, New Haven, Connecticut

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Y. Wang

bDepartments of Radiology (Y.Z., A.G., J.C., G.C.-Y.C., D.Z., Y.W.)

fDepartment of Biomedical Engineering (Y.W.), Cornell University, Ithaca, New York.

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Y. Zhang, S.A. Gauthier, A. Gupta, W. Chen, J. Comunale, G.C.-Y. Chiang, D. Zhou, G. Askin, W. Zhu, D. Pitt, Y. Wang

Quantitative Susceptibility Mapping and R2* Measured Changes during White Matter Lesion Development in Multiple Sclerosis: Myelin Breakdown, Myelin Debris Degradation and Removal, and Iron Accumulation

American Journal of Neuroradiology Sep 2016, 37 (9) 1629-1635; DOI: 10.3174/ajnr.A4825

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Y. Zhang, S.A. Gauthier, A. Gupta, W. Chen, J. Comunale, G.C.-Y. Chiang, D. Zhou, G. Askin, W. Zhu, D. Pitt, Y. Wang

American Journal of Neuroradiology Sep 2016, 37 (9) 1629-1635; DOI: 10.3174/ajnr.A4825

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