Article Figures & Data
Figures
- Fig 1.
Effect of the flip angle on recovery of CBV (TE = 35 ms/TR = 1.0 second). A, Percentage error (with 95% CI) of the estimated CBV for different flip angles and leakage-correction strategies, without the use of preload, compared with ground truth CBV. B, Percentage error (with 95% CI) of the estimated CBV for different flip angles and leakage-correction strategies, with use of ¼ dose preload, compared with ground truth CBV.
- Fig 2.
Effect of TE and TR on CBV accuracy with flip angle = 60°. A, Percentage error in CBV estimation for different TEs by using TR = 1.0 second without preload. B, Percentage error in CBV estimation for different TEs by using TR = 1.0 second with ¼ dose preload. C, Percentage error in CBV estimation for different TRs with a 60° flip angle and TE = 35 ms with no preload. D, Percentage error in CBV estimation for different TRs with a 60° flip angle and TE = 35 ms with a ¼ dose preload.
- Fig 3.
Effects of preload dosage, incubation time, and truncation of corrected ΔR*2(t) on CBV fidelity. A, Percentage errors in CBV for each preload dosage with 95% CI. The best performance was obtained with 1-dose preload and 1-dose DSC-MR imaging bolus when using TE = 35 ms, TR = 1.0 second, and flip angle = 60°. Note the increased T2*-weighting from a full-dose preload decreases the CBV error when using these acquisition parameters. B, Effects of preload incubation time on CBV estimation when using preload. C, Effects of truncation of the ΔR*2(t) curves and leakage-correction strategies on CBV estimation when using a 1-dose preload followed by a 1-dose DSC bolus injection.
- Fig 4.
Heat map diagrams depicting the percentage error in the CBV estimation for combinations of acquisition protocols with Bidir. Each quadrant within each subfigure represents a different preload dose. Each subfigure represents a different flip angle: 90° (A), 60° (B), and 35° (C). Optimal strategies balance T1-weighted and T2*-weighted effects from contrast agent extravasation via a combination of TE, TR, and preload. Red boxes indicate acquisition protocols with minimum error, while blue boxes indicate protocols with poor CBV fidelity (high error compared with ground truth).
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