Research ArticleAdult Brain
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Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, I. Paunkoski, D.P. Ramasamy, D. Silva, E. Carl, D. Hojnacki, C. Kolb, B. Weinstock-Guttman and R. Zivadinov
American Journal of Neuroradiology December 2018, 39 (12) 2237-2242; DOI: https://doi.org/10.3174/ajnr.A5876
E. Ghione
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
N. Bergsland
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
M.G. Dwyer
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at Clinical Translational Research Center (M.G.D., R.Z.), State University of New York, Buffalo, New York
J. Hagemeier
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
D. Jakimovski
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
I. Paunkoski
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
D.P. Ramasamy
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
D. Silva
dNovartis Pharmaceuticals AG (D.S.), Basel, Switzerland.
E. Carl
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
D. Hojnacki
bJacobs Comprehensive MS Treatment and Research Center (D.H., C.K., B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
C. Kolb
bJacobs Comprehensive MS Treatment and Research Center (D.H., C.K., B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
B. Weinstock-Guttman
bJacobs Comprehensive MS Treatment and Research Center (D.H., C.K., B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
R. Zivadinov
aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
cCenter for Biomedical Imaging at Clinical Translational Research Center (M.G.D., R.Z.), State University of New York, Buffalo, New York

Article Information
vol. 39 no. 12 2237-2242
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History
- Received July 19, 2018
- Accepted after revision September 8, 2018
- Published online December 14, 2018.
Article Versions
- Latest version (November 22, 2018 - 08:32).
- You are viewing the most recent version of this article.
Copyright & Usage
© 2018 by American Journal of Neuroradiology Indicates open access to non-subscribers at www.ajnr.org
Author Information
- E. Ghionea,
- N. Bergslanda,
- M.G. Dwyera,c,
- J. Hagemeiera,
- D. Jakimovskia,
- I. Paunkoskia,
- D.P. Ramasamya,
- D. Silvad,
- E. Carla,
- D. Hojnackib,
- C. Kolbb,
- B. Weinstock-Guttmanb and
- R. Zivadinova,c
- aFrom the Department of Neurology (E.G., N.B., M.G.D., J.H., D.J., I.P., D.P.R., E.C., R.Z.), Buffalo Neuroimaging Analysis Center
- bJacobs Comprehensive MS Treatment and Research Center (D.H., C.K., B.W.-G.), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
- cCenter for Biomedical Imaging at Clinical Translational Research Center (M.G.D., R.Z.), State University of New York, Buffalo, New York
- dNovartis Pharmaceuticals AG (D.S.), Basel, Switzerland.
- Please address correspondence to Robert Zivadinov, MD, PhD, Buffalo Neuroimaging Analysis Center, Center Biomedical Imaging at Clinical Translational Research Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, 100 High St, Buffalo, NY 14203; e-mail: rzivadinov{at}bnac.net
Funding
Research reported in this publication was funded by the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) under award Number UL1TR001412. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.
Study was supported in part by Novartis Pharmaceuticals AG, Switzerland.
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E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, I. Paunkoski, D.P. Ramasamy, D. Silva, E. Carl, D. Hojnacki, C. Kolb, B. Weinstock-Guttman, R. Zivadinov
Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine
American Journal of Neuroradiology Dec 2018, 39 (12) 2237-2242; DOI: 10.3174/ajnr.A5876
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Brain Atrophy Is Associated with Disability Progression in Patients with MS followed in a Clinical Routine
E. Ghione, N. Bergsland, M.G. Dwyer, J. Hagemeier, D. Jakimovski, I. Paunkoski, D.P. Ramasamy, D. Silva, E. Carl, D. Hojnacki, C. Kolb, B. Weinstock-Guttman, R. Zivadinov
American Journal of Neuroradiology Dec 2018, 39 (12) 2237-2242; DOI: 10.3174/ajnr.A5876
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